Functionalization of 4,6-dinitro-2-phenylindole at position 7

Bastrakov, Maxim A.; Старосотников, А. М.; Shakhnes, A. Kh.; Шевелев, С. А.

doi:10.1007/s11172-008-0198-1

Cited by 7 publications

(1 citation statement)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1 H, 13 C and 15 N NMR chemical shifts of nitroazoles and their aminated products (ppm) (DMSO-d6). Likewise, 2-Aryl-1-methyl-4,6-dinitroindoles are aminated by TMHI in the presence of t-BuOK/DMSO exclusively at position 7 to afford 7-amino-substituted, ortho-nitro amines (Scheme 7, Table 1) [95]. The transformation of 7-NH2 allows the employment of 2-aryl-4,6-dinitroindoles as a basis to obtain new indole derivatives with potentially useful biological properties.…”

Section: Compoundmentioning

confidence: 99%

The Structure of Biologically Active Functionalized Azoles: NMR Spectroscopy and Quantum Chemistry

Ларина

2022

Magnetochemistry

View full text Add to dashboard Cite

This review summarizes the data on the stereochemical structure of functionalized azoles (pyrazoles, imidazoles, triazoles, thiazoles, and benzazoles) and related compounds obtained by multipulse and multinuclear 1H, 13C, 15N NMR spectroscopy and quantum chemistry. The stereochemistry of functionalized azoles is a challenging topic of theoretical research, as the correct interpretation of their chemical behavior and biological activity depends on understanding the factors that determine the stereochemical features and relative stability of their tautomers. NMR spectroscopy, in combination with quantum chemical calculations, is the most convenient and reliable approach to the evaluation of the stereochemical behavior of, in particular, nitrogen-containing heteroaromatic and heterocyclic compounds. Over the last decade, 15N NMR spectroscopy has become almost an express method for the determination of the structure of nitrogen-containing heterocycles.

show abstract

Section: Compoundmentioning

confidence: 99%