2023
DOI: 10.3389/fbioe.2023.1254299
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Functionalization of breast implants by cyclodextrin in-situ polymerization: a local drug delivery system for augmentation mammaplasty

Karen Escobar,
Ignacio Carrera,
Nelson Naveas
et al.

Abstract: Mammaplasty is a widely performed surgical procedure worldwide, utilized for breast reconstruction, in the context of breast cancer treatment, and aesthetic purposes. To enhance post-operative outcomes and reduce risks (hematoma with required evacuation, capsular contracture, implant-associated infection and others), the controlled release of medicaments can be achieved using drug delivery systems based on cyclodextrins (CDs). In this study, our objective was to functionalize commercially available silicone br… Show more

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Cited by 3 publications
(7 citation statements)
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“…In contrast, the textured samples featured a thicker membrane, measuring around 520 μm in thickness, and presented valleys with depths ranging from 100 to 150 μm. Figure 5 in the study by K. Escobar et al (2023) [ 8 ] showcases additional perspectives of these substrates.…”
Section: Results and Discussionmentioning
confidence: 98%
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“…In contrast, the textured samples featured a thicker membrane, measuring around 520 μm in thickness, and presented valleys with depths ranging from 100 to 150 μm. Figure 5 in the study by K. Escobar et al (2023) [ 8 ] showcases additional perspectives of these substrates.…”
Section: Results and Discussionmentioning
confidence: 98%
“…Recently, K. Escobar et al (2023) [ 8 ] obtained diffusion coefficient (D) values for these systems using the semi-empirical “monolithic solution” model. This model is applied when drugs are molecularly dispersed in the matrix former or when the drug rapidly dissolves upon water penetration into the system [ 18 ].…”
Section: Results and Discussionmentioning
confidence: 99%
See 3 more Smart Citations