Functionalization of graphene oxide quantum dots for anticancer drug delivery

Mohammed-Ahmed, Heba K.; Nakipoğlu, Mustafa; Tezcaner, Ayşen; Keskin, Dilek; Evis, Zafer

doi:10.1016/j.jddst.2023.104199

Cited by 13 publications

(6 citation statements)

References 61 publications

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“…Mohammed‐Ahmed et al prepared nanoconjugates by the combination of GQDs, glucosamine, and boric acid. It was reported that the addition of boric acid to the conjugate increased the loading and release of doxorubicin drug with higher internalization into MCF‐7 cancer cells along with higher cytotoxicity (Mohammed‐Ahmed et al, 2023). Mirzababaei et al coated GQDs with the polymer of methacrylic acid‐co‐diallyldimethylammonium chloride and imprinted doxorubicin with the GQD‐coated polymer.…”

Section: Carbon Quantum Dots In Drug Deliverymentioning

confidence: 99%

“…The nanocarriers were reported to have enhanced loading capacity for doxorubicin and effective against cancerous cells at low concentration when loaded to the drug(Kurniawan et al, 2023).Mohammed-Ahmed et al prepared nanoconjugates by the combination of GQDs, glucosamine, and boric acid. It was reported that the addition of boric acid to the conjugate increased the loading and release of doxorubicin drug with higher internalization into MCF-7 cancer cells along with higher cytotoxicity(Mohammed-Ahmed et al, 2023).Mirzababaei et al coated GQDs with the polymer of methacrylic acid-co-diallyldimethylammonium chloride and imprinted doxorubicin with the GQD-coated polymer.The coated GQDs were characterized and injected into mice with breast cancer, where in vivo imaging showed accumulation of the conjugate in the vicinity of cancer cells(Mirzababaei et al, 2023).Kaliyaperumal et al prepared nanoparticles from methyl N-allyl N-benzoylmethioninate and GQDs, which showed good activity in the defibrillation of α-synuclein in vitro. The nanocomposite was reported to cross the BBB in vitro and cure neurodegeneration in Parkinson's disease(Kaliyaperumal et al, 2023).Heidari et al prepared a nanocarrier by conjugating β-cyclodextran, GQDs, and b-PEI and attached the micro RNA miR21a to the nanocarrier.…”

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confidence: 99%

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Recent advances in biomedical applications of carbon and graphene quantum dots: A review

Das,

Roy,

Saha

2024

Biotech & Bioengineering

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The carbon‐based nanostructures have led to the development of theranostic nanoplatforms for simultaneous diagnosis and therapy due to their effective cell membrane‐penetration ability, low degree of cytotoxicity, excellent pore volume, substantial chemical stability, and reactive surface. In the last few years, extensive efforts were made to design multifunctional nanoplatform strategies based on carbon nanostructures, involving multimodal imaging, controlled drug release capabilities, sensing in vitro, efficient drug loading capacity, and therapy. Carbon and graphene quantum dots (CQDs and GQDs) were the recent entrants, contingently being assessed for drug delivery and bioimaging. With the advancements, these quantum dots have ignited remarkable research interest and are now widely evaluated for diagnosis, bioimaging, sensing, and drug delivery applications. The last decade has witnessed their remarkable electrical, optical, and biocompatible properties since their inception. It is presumed that both of them have high potential as drug carriers and would serve as the next generation of approaches to address numerous unresolved therapeutic challenges. This review examined the recent advances of CQD and GQD based drug delivery applications, challenges, and future perspectives to pave the way for further studies in the future.

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Section: Carbon Quantum Dots In Drug Deliverymentioning

confidence: 99%

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confidence: 99%

Recent advances in biomedical applications of carbon and graphene quantum dots: A review

Das,

Roy,

Saha

2024

Biotech & Bioengineering

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“…It is noteworthy that with the presence of doxorubicin, more cytotoxicity has been reported against MCF-7 cells. On the other hand, the above compound can have more potential to deliver anti-cancer drugs [10]. Of course, in the future, it is necessary for researchers to conduct more research on the development of quantum Graphene composites in order to reduce the level of cytotoxicity.…”

Section: Gqds In the Form Of Compositesmentioning

confidence: 99%

Advancements in Biomaterials Development Using Graphene Quantum Dots: A Mini Review

Ashkani

2024

SBB

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Today, Graphene Quantum Dots (GQDs) have attracted the attention of researchers in various industries. The development of these materials in bioscience and biomaterials is also significant. Graphene quantum dots are of interest due to their unique features in in-vivo imaging, develop drug delivery materials and improving the performance of dental implants. In the present research, some of the latest achievements in this field have been collected as a mini review. Graphene quantum dots can be used in drug delivery applications, development of in vivo imaging and similar cases. At the end of each section, suggestions are provided for researchers and more developing of Graphene quantum dots. Notably, this article only examines the latest achievements in the field of Graphene quantum dots and its results do not confirm or deny the use of this material in bioscience and biomaterials.

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“…Moreover, quantum dots show better properties with more active groups on their surface than typical graphene and graphene oxide. They exhibit unique properties, i.e., water solubility, non-toxicity, high biocompatibility, a small size with a large surface area, high drug loading capacity, and better cellular uptake [85][86][87]. Mohammed-Ahmed H.K.…”

Section: Drug Deliverymentioning

confidence: 99%

Graphene Production and Biomedical Applications: A Review

Malisz,

Świeczko-Żurek

2023

Crystals

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Graphene is a two-dimensional nanomaterial composed of carbon atoms with sp2 hybrid orbitals. Both graphene and graphene-based composite have gained broad interest among researchers because of their outstanding physiochemical, mechanical, and biological properties. Graphene production techniques are divided into top-down and bottom-up synthesis methods, of which chemical vapor deposition (CVD) is the most popular. The biomedical applications of graphene and its composite include its use in sensors, implantology, and gene and drug delivery. They can be used for tissue engineering, anticancer therapies, and as antimicrobial agents in implant application. The biocompatibility of graphene-based nanomaterials enables their use in the field of biomedicine. This article reviews the properties of graphene, the methods used to produce it, the challenges associated with its use, and the potential applications of this material in biomedicine, regenerative medicine, and drug delivery systems.

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Functionalization of graphene oxide quantum dots for anticancer drug delivery

Cited by 13 publications

References 61 publications

Recent advances in biomedical applications of carbon and graphene quantum dots: A review

Recent advances in biomedical applications of carbon and graphene quantum dots: A review

Advancements in Biomaterials Development Using Graphene Quantum Dots: A Mini Review

Graphene Production and Biomedical Applications: A Review

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