Functionalization of multi-walled carbon nanotubes with poly(amidoamine) dendrimer for mediator-free glucose biosensor

Zeng, Yun-Long; Huang, Yu-Fang; Jiang, Jian‐Hui; Zhang, Xiaobing; Tang, Chunran; Shen, Guo‐Li; Yu, Ru‐Qin

doi:10.1016/j.elecom.2006.08.052

Cited by 108 publications

(33 citation statements)

References 24 publications

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“…End-wall attachment of the biomolecules, such as glucose oxidase [71] and microperoxidase MP-11 [70], to CNTs has also been shown. Recently, bienzymatic (glucose oxidase and horseradish peroxide) modification and assembly of CNTs covalently linked with a poly(amidoamine) (PAMAM) dendrimer have been demonstrated [89]. This is achieved by using amidation reaction to link the dendrimer to the CNTs, followed by the reduction of Schiff bases formed between the CNTlinked dendrimer and bienzymes using sodium borohydride [89].…”

Section: Surface Functionalization Of Carbon Nanotubes and Configuratmentioning

confidence: 99%

Carbon Nanotube–Based Sensors and Biosensors

Compton

Wildgoose

Wong

2009

Biosensing Using Nanomaterials

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Section: Surface Functionalization Of Carbon Nanotubes and Configuratmentioning

confidence: 99%

Carbon Nanotube–Based Sensors and Biosensors

Compton

Wildgoose

Wong

2009

Biosensing Using Nanomaterials

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“…Therefore, a second, redox-active enzyme must be employed to mediate detection of oxidase-substrate interactions. For example, glucose oxidase (GOx) and horseradish peroxidase (HRP) have been covalently linked to CNTs through poly(amidoamine) dendrimers, (13) permitting the detection of glucose through HRPmediated H 2 O 2 consumption. Additionally, small redox molecules such as ferrocenes have been used to mediate glucose and glutamate detection (4,17).…”

Section: Introductionmentioning

confidence: 99%

Peroxidase Mimetic Activity at Tailored Nanocarbon Electrodes

Lyon

Stevenson²

2009

ECS Trans.

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We demonstrate here the intrinsic reactivity of nitrogen-doped carbon nanotubes (N-CNTs) toward H2O2 consumption and their use as a potential peroxidase mimetic. Analysis of N-CNT-modified glassy carbon electrodes in an rotating disk electrode (RDE) amperometry configuration indicates that the mechanism of H2O2 consumption is not a 2-electron reduction to H2O, as is observed for peroxidase-catalyzed H2O2 reduction. We believe that the N-CNT reaction mechanism toward H2O2 occurs through the decomposition of H2O2 to O2 and H2O, resulting in an increase in current at the N-CNT electrode as the newly generated H2O2 is electrochemically reduced. We have exploited this intrinsic reactivity by incorporating N-CNTs as a substitute for horseradish peroxidase (HRP) in a traditionally bi-enzymatic sensing scheme for the detection of glucose. These studies serve as proof of concept for the use of N-CNTs as a peroxidase mimetic in unmediated biogenic analyte detection.

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“…Nanoparticles such as carbon nanotubes (CNTs) and gold nanopartlcles (AuNPs) possess high electrocatalytic active, specific electronic properties, can facilitate electron transfer between the electroactive species and electrode, provide a new avenue for fabricating biosensors [11][12][13]. Many modified electrodes based on CNTs have been widely used for the study of DA, such as CNTs paste modified electrode, single walled carbon nanotube-modified platinum electrode [14], single-walled carbon nanotubes-Fc modified glassy carbon electrode (GCE) [15], Nafion/carbon nanotubes coated poly(3-methylthiophene) modified GCE [16], multi-walled carbon nanotubes (MWCNTs) modified gold electrode [17], layer-by-layer assembled MWCNTs modified electrode [18], etc.…”

Section: Introductionmentioning

confidence: 99%

Selective response of dopamine in the presence of ascorbic acid and uric acid at gold nanoparticles and multi-walled carbon nanotubes grafted with ethylene diamine tetraacetic acid modified electrode

Tang¹,

Wang²,

Su³

et al. 2009

Bull. Chem. Soc. Eth.

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ABSTRACT.ABSTRACT. ABSTRACT. ABSTRACT. By grafting with ethylene diamine tetraacetic acid (EDTA), novel multi-walled carbon nanotube nano-composites (EDTA-MWCNTs) have been successfully prepared. The integration of gold nanoparticles (AuNPs) and novel functionalized matrix shows very promising applications in the fabrication of biosensors for sensitive detection of dopamine in the presence of ascorbic acid and uric acid with the combination of the charge repelling property of carboxylic anion and the electrocatalytic effect of EDTA. The AuNPs and EDTA-MWCNTs modified film shows excellent sensitivity and selectivity for the dopamine analysis due to the synergic effect of AuNPs and EDTA-MWCNTs. As high as 2000 fold and 150 fold acceptable tolerance of ascorbic acid and uric acid for the determination of trace dopamine is reached, respectively. The linear concentration range for dopamine is from 1.0 × 10 -8 to 6.0 × 10 -6 mol.L -1, and the detection limit is 3.0 × 10 -9 mol.L -1 . The response of the sensor is very quick and response time is less than 1 s. The method can be applied to detect the dopamine in human urine samples. KEY WORDS: KEY WORDS: KEY WORDS:

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Functionalization of multi-walled carbon nanotubes with poly(amidoamine) dendrimer for mediator-free glucose biosensor

Cited by 108 publications

References 24 publications

Carbon Nanotube–Based Sensors and Biosensors

Carbon Nanotube–Based Sensors and Biosensors

Peroxidase Mimetic Activity at Tailored Nanocarbon Electrodes

Selective response of dopamine in the presence of ascorbic acid and uric acid at gold nanoparticles and multi-walled carbon nanotubes grafted with ethylene diamine tetraacetic acid modified electrode

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