Functionalization of nanocellulose applied with biological molecules for biomedical application: A review

Shi, Yifei; Jiao, Haixin; Sun, Jianzhong; Lu, Xuechu; Yu, Sujie; Liu, Cheng; Wang, Qainqian; Liu, Huan; Biranje, Santosh; Li, Jun

doi:10.1016/j.carbpol.2022.119208

Cited by 57 publications

(24 citation statements)

References 99 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the one hand, in the context of nonbiomedical applications, CD-based coatings have been used to prevent corrosion problems and to remediate pollutants or dyes. On the other hand, for biomedical applications, the importance of CD-based surface coatings has increased, in terms of both biocompatibility and drug delivery [ 51 , 52 , 53 ], mainly intended as molecular delivery systems, such as the delivery of antibiotics [ 42 , 43 ] and drugs [ 44 , 45 , 46 ], among others.…”

Section: Coatings Of Cyclodextrin/citric Acid Biopolymer As Drug-deli...mentioning

confidence: 99%

Coatings of Cyclodextrin/Citric-Acid Biopolymer as Drug Delivery Systems: A Review

et al. 2023

View full text Add to dashboard Cite

In the early 2000s, a method for cross-linking cyclodextrins (CDs) with citric acid (CTR) was developed. This method was nontoxic, environmentally friendly, and inexpensive compared to the others previously proposed in the literature. Since then, the CD/CTR biopolymers have been widely used as a coating on implants and other materials for biomedical applications. The present review aims to cover the chemical properties of CDs, the synthesis routes of CD/CTR, and their applications as drug-delivery systems when coated on different substrates. Likewise, the molecules released and other pharmaceutical aspects involved are addressed. Moreover, the different methods of pretreatment applied on the substrates before the in situ polymerization of CD/CTR are also reviewed as a key element in the final functionality. This process is not trivial because it depends on the surface chemistry, geometry, and physical properties of the material to be coated. The biocompatibility of the polymer was also highlighted. Finally, the mechanisms of release generated in the CD/CTR coatings were analyzed, including the mathematical model of Korsmeyer–Peppas, which has been dominantly used to explain the release kinetics of drug-delivery systems based on these biopolymers. The flexibility of CD/CTR to host a wide variety of drugs, of the in situ polymerization to integrate with diverse implantable materials, and the controllable release kinetics provide a set of advantages, thereby ensuring a wide range of future uses.

show abstract

Section: Coatings Of Cyclodextrin/citric Acid Biopolymer As Drug-deli...mentioning

confidence: 99%

Coatings of Cyclodextrin/Citric-Acid Biopolymer as Drug Delivery Systems: A Review

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Apart from water/oil separation, Janus CNF membranes might be also considered to be useful in biomedical applications. CNF membranes as wound dressings have been widely explored due to their biocompatibility, noncytotoxicity, good mechanical strength, and moisture retention capacity. , Janus CNM wound dressings fabricated by sequential electrospinning deposition and freeze-casting are more attractive than conventional CNM wound dressings. , Janus CNM sponges with different wettabilities were developed using heterogeneous mixing and freeze-drying, resulting in a multilayer structure containing a disordered hydrophobic layer, a lamellar hydrophilic layer, and a transitional interphase . The inner hydrophilic layer is mainly responsible for quick blood clotting by water adsorption in a passive hemostatic manner.…”

Section: Janus Cnm Membranes and Their Applicationmentioning

confidence: 99%

Naturally Derived Janus Cellulose Nanomaterials: Anisotropic Cellulose Nanomaterial Building Blocks and Their Assembly into Asymmetric Structures

et al. 2022

Self Cite

View full text Add to dashboard Cite

Naturally derived cellulose nanomaterials (CNMs) with desirable physicochemical properties have drawn tremendous attention for their versatile applications in a broad range of fields. More recently, Janus amphiphilic cellulose nanomaterial particles with asymmetric structures (i.e., reducing and nonreducing ends and crystalline and amorphous domains) have been in the spotlight, offering a rich and sophisticated toolbox for Janus nanomaterials. With careful surface and interfacial engineering, Janus CNM particles have demonstrated great potential as surface modifiers, emulsifiers, stabilizers, compatibilizers, and dispersants in emulsions, nanocomposites, and suspensions. Naturally derived Janus CNM particles offer a fascinating opportunity for scaling up the production of self-standing Janus CNM membranes. Nevertheless, most Janus CNM membranes to date are constructed by asymmetric fabrication or asymmetric modification without considering the Janus traits of CNM particles. More future research should focus on the self-assembly of Janus CNM particles into bulk self-standing Janus CNM membranes to enable more straightforward and sustainable approaches for Janus membranes. This review explores the fabrication, structure–property relationship, and Janus configuration mechanisms of Janus CNM particles and membranes. Janus CNM membranes are highlighted for their versatile applications in liquid, thermal, and light management. This review also highlights the significant advances and future perspectives in the construction and application of sustainable Janus CNM particles and membranes.

show abstract

“…3 Shi et al outlined the functionalization strategies of the CNC for biomedical applications. 26 Ghasemlou et al reported the surface modification strategies of the CNC, emphasizing the quantification of substitution and the level of dispersibility in organic solvents. 27 Chu et al discussed the influence of colloids and surface chemistry on the nanocellulose dispersibility in solvents and polymer matrices.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…In the past few years, many reviews have summarized the preparation, modification, functionalization, and applications of the CNC. ,− For example, Wang et al compared the advantages and disadvantages of nanocellulose preparation methods . Shi et al outlined the functionalization strategies of the CNC for biomedical applications . Ghasemlou et al reported the surface modification strategies of the CNC, emphasizing the quantification of substitution and the level of dispersibility in organic solvents .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Dispersibility Characterization of Cellulose Nanocrystals in Polymeric-Based Composites

Zhu

Lin

2022

Biomacromolecules

View full text Add to dashboard Cite

Cellulose nanocrystals (CNCs) are hydrophilic nanoparticles extracted from biomass with properties and functions different from cellulose and are being developed for property-oriented applications such as high stiffness, abundant active groups, and biocompatibility. It has broad application prospects in the field of composite materials, while the dispersibility of the CNC in polymers is the key to its application performance. Many reviews have discussed in-depth the modification strategies to improve the dispersibility of the CNC and summarized all characterization for the CNC, but there are no reviews on the in-depth exploration of dispersion characterization. This review is a comprehensive summary of the characterization of CNC dispersion in the matrix in terms of direct observation, indirect evaluation, and quantified evaluation, summarizing how and why different characterization tools reveal dispersibility. In addition, "decision tree" flowcharts are presented to provide the reader with a reference for selecting the appropriate characterization method for a specific composite.

show abstract

Functionalization of nanocellulose applied with biological molecules for biomedical application: A review

Cited by 57 publications

References 99 publications

Coatings of Cyclodextrin/Citric-Acid Biopolymer as Drug Delivery Systems: A Review

Coatings of Cyclodextrin/Citric-Acid Biopolymer as Drug Delivery Systems: A Review

Naturally Derived Janus Cellulose Nanomaterials: Anisotropic Cellulose Nanomaterial Building Blocks and Their Assembly into Asymmetric Structures

Dispersibility Characterization of Cellulose Nanocrystals in Polymeric-Based Composites

Contact Info

Product

Resources

About