Functionalization of peptide nucleolipid bioconjugates and their structure anti-cancer activity relationship studies

Rana, Niki K.; Cultrara, Christopher; Phillips, Mariana; Sabatino, David A.

doi:10.1016/j.bmcl.2017.07.056

Bioorganic & Medicinal Chemistry Letters

2017

DOI: 10.1016/j.bmcl.2017.07.056

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Functionalization of peptide nucleolipid bioconjugates and their structure anti-cancer activity relationship studies

Niki K. Rana

Christopher Cultrara

Mariana Phillips

et al.

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2022

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Dimeric Artesunate Glycerophosphocholine Conjugate Nano-Assemblies as Slow-Release Antimalarials to Overcome Kelch 13 Mutant Artemisinin Resistance

Giannangelo

et al. 2022

Antimicrob Agents Chemother

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Current best practice for the treatment of malaria relies on short half-life artemisinins that are failing against emerging Kelch 13 mutant parasite strains. Here, we introduce a liposome-like self-assembly of a dimeric artesunate glycerophosphocholine conjugate (dAPC-S) as an amphiphilic prodrug for the short-lived antimalarial drug, dihydroartemisinin (DHA), with enhanced killing of Kelch 13 mutant artemisinin-resistant parasites.

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Dimeric Artesunate Glycerophosphocholine Conjugate Nano-Assemblies as Slow-Release Antimalarials to Overcome Kelch 13 Mutant Artemisinin Resistance

Giannangelo

et al. 2022

Antimicrob Agents Chemother

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show abstract

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Functionalization of peptide nucleolipid bioconjugates and their structure anti-cancer activity relationship studies

Cited by 1 publication

References 26 publications

Dimeric Artesunate Glycerophosphocholine Conjugate Nano-Assemblies as Slow-Release Antimalarials to Overcome Kelch 13 Mutant Artemisinin Resistance

Dimeric Artesunate Glycerophosphocholine Conjugate Nano-Assemblies as Slow-Release Antimalarials to Overcome Kelch 13 Mutant Artemisinin Resistance

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