Functionalization of Polycarbonate Surfaces by Grafting <scp>PEG</scp> and Zwitterionic Polymers with a Multicomb Structure

Yang, Jing; Lv, Juan; Behl, Marc; Lendlein, Andreas; Yang, Di; Zhang, Li; Shi, Changcan; Guo, Jintang; Feng, Yakai

doi:10.1002/mabi.201300264

Cited by 38 publications

(26 citation statements)

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“…RDRP techniques offer direct access to polymers bearing zwitterionic groups with previously unthinkable features, such as predefined molar masses and narrow molar mass distributions [163,[182][183][184][185][186][187][188][189] as well as well-defined functional end groups [61,166,182,[190][191][192][193][194][195][196][197][198][199][200][201][202][203][204][205][206][207][208]. Moreover, complex architectures, such as block copolymers [14,[46][47][48]166,167,169,173,187,, graft copolymers [164,213,237,[241][242][243][244]…”

Section: Synthesis By Chain Growth Polymerizationsmentioning

confidence: 99%

Structures and Synthesis of Zwitterionic Polymers

2014

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Abstract:The structures and synthesis of polyzwitterions ("polybetaines") are reviewed, emphasizing the literature of the past decade. Particular attention is given to the general challenges faced, and to successful strategies to obtain polymers with a true balance of permanent cationic and anionic groups, thus resulting in an overall zero charge. Also, the progress due to applying new methodologies from general polymer synthesis, such as controlled polymerization methods or the use of "click" chemical reactions is presented. Furthermore, the emerging topic of responsive ("smart") polyzwitterions is addressed. The considerations and critical discussions are illustrated by typical examples.

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Section: Synthesis By Chain Growth Polymerizationsmentioning

confidence: 99%

Structures and Synthesis of Zwitterionic Polymers

2014

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“…The first approach is to improve the hemocompatibility of the internal lumen of the grafts with some antithrombogenic treatments or agents. Hydrophilic polymers, zwitterionic polymers, and antithrombogenic drugs have been widely used to improve the hemocompatibility of biomaterial surface . Polyethylene glycol (PEG) and other hydrophilic polymers can inhibit platelet adhesion and nonspecific protein adsorption, thus enhancing hemocompatibility.…”

Section: Introductionmentioning

confidence: 99%

Biofunctionalized Electrospun PCL‐PIBMD/SF Vascular Grafts with PEG and Cell‐Adhesive Peptides for Endothelialization

Bai

Zhao

et al. 2018

Macromolecular Bioscience

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Artificial small‐caliber vascular grafts are still limited in clinical application because of thrombosis, restenosis, and occlusion. Herein, a small‐caliber vascular graft (diameter 2 mm) is fabricated from poly(ε‐caprolactone)‐b‐poly(isobutyl‐morpholine‐2,5‐dione) (PCL‐PIBMD) and silk fibroin (SF) by electrospinning technology and then biofunctionalized with low‐fouling poly(ethylene glycol) (PEG) and two cell‐adhesive peptide sequences (CREDVW and CAGW) with the purpose of enhancing antithrombogenic activity and endothelialization. The successful grafting of PEG and peptide sequences is confirmed by X‐ray photoelectron spectroscopy. The suitable surface wettability of the modified vascular graft is testified by water contact angle analysis. The surface hemocompatibility is verified by platelet adhesion assays and protein adsorption assays, and the results demonstrate that both platelet adhesion and protein adsorption on the biofunctionalized surface are significantly reduced. In vitro studies demonstrate that the biofunctionalized surface with suitable hydrophilicity and cell‐adhesive peptides can selectively promote the adhesion, spreading, and proliferation of human umbilical vein endothelial cells. More importantly, compared with control groups, this biofunctionalized small‐caliber vascular graft shows high long‐term patency and endothelialization after 10 weeks of implantation. The biofunctionalization with PEG and two cell‐adhesive peptide sequences is an effective method to improve the endothelialization and long‐term performance of synthetic vascular grafts.

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“…4,5 For example, silk fiber, collagen, heparin, poly(ethylene glycol), gelatin, zwitterionic polynorbornene and 2-methacryloyloxyethyl phosphorylcholine have been widely used in surface modification of artificial blood scaffolds. [6][7][8][9][10][11][12][13][14] The hydrophilicity, hemocompatibility and biocompatibility of artificial blood vessels have been improved greatly after surface modification.…”

Section: Introductionmentioning

confidence: 99%