Functionalization of polymer multilayer thin films for novel biomedical applications

Abstract

The design of functional polymer multilayer thin films with nanometer scale control is of great interest for biomedical applications such as tissue engineering, targeted drug delivery, controlled release system, and regenerative medicine. Various functions and properties of polymer thin films can be easily programmed and realized by the layer-by-layer assembly strategy, which is a facile and versatile deposition method to prepare well-defined biomedical multilayer platforms due to its benign process to prepare films under mild conditions and the capability of incorporating bioactive materials at a desired location within the films. Particularly, the fine tuning of physicochemical and biological properties of multilayer thin films is significantly important for designing novel biomedical platforms capable of adjusting the cellular functions. In this review, we focus on the overall background of the layer-by-layer assembly as well as the tuning of multilayer film properties and the programming of biological functions into the polymer thin films with a view on the control of cellular functions. Furthermore, we highlighted the recent achievements toward the design of novel biomedical platforms based on functionalized polymer multilayer thin films.

Modeling and simulation of biopolymer networks: Classification of the cytoskeleton models according to multiple scales

“…Conversely, models can be selected based on the length scale of the phenomena of interest. The correct prediction of biopolymer network mechanical/rheological properties is important in many biomedical applications associated with biopolymer networks [1,130,131]. Therefore, the framework provided by this review is expected to promote various studies on biopolymer networks.…”

Delivery of bone morphogenetic protein-2 and substance P using graphene oxide for bone regeneration

“…GO multilayer films were deposited on the Ti substrates by layer-by-layer (LbL) assembly. 34,35 Briefly, the substrates were then dipped for 10 minutes in the cationic GO-NH 3 + solution, washed three times by dipping in deionized water for 1 minute, and then dried with a gentle stream of nitrogen. The negatively charged GO-COO − was subsequently deposited onto the GO-NH 3 + coated films using the same adsorption, washing, and drying procedures described above.…”

“…29,34,35 Coating with multiple layers of GO resulted in a full coverage of the Ti substrate ( Figure 1A). Atomic force microscopy revealed that, unlike the bumpy surface of an uncoated Ti substrate, the GOcoated Ti surfaces became much smoother after multiple cycles of LbL deposition.…”

Layer‐by‐Layer Processed Multilayers: Challenges and Opportunities

“…Suitably engineered polyelectrolyte multilayers (PEMs) have long been recognized as versatile biomaterial platforms due to their similarity to naturally occurring, highly hydrated systems, ease of biochemical functionalization, high level of biocompatibility and tunable mechanical compliance [30][31][32][33][34]. These attributes can be realized with synthetic polymers, and more importantly, with naturally occurring polymers, including DNA, polypeptides and polysaccharides.…”