Functionalization of Tamarind Gum for Drug Delivery

Nayak, Amit Kumar; Pal, Dilipkumar

doi:10.1007/978-3-319-66417-0_2

Cited by 28 publications

(13 citation statements)

References 80 publications

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“…The TGP formed a heap of a pile on the surface from where the radius can be calculated. The angle of repose can be determined using Equation (6).…”

Section: Powder Flow Propertymentioning

confidence: 99%

“…In recent years, it has been extensively studied and used as a successful pharmaceutical excipient in a variety of drug delivery applications. Tamarind gum is used in the development of drug delivery systems for the oral, intestinal, ophthalmic, buccal, and nasal routes [ 6 ]. The chemical structure of tamarind seed polymer are shown in Figure 1 .…”

Section: Introductionmentioning

confidence: 99%

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Evaluation and Characterization of Tamarind Gum Polysaccharide: The Biopolymer

et al. 2021

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Polymers from natural sources are widely used as excipients in the formulation of pharmaceutical dosage forms. The objective of this study was to extract and further characterize the tamarind gum polysaccharide (TGP) obtained from Tamarindus indica as an excipient for biomedical applications. Double distilled water was used as a solvent for the extraction of gum while Ethyl alcohol was used as an antisolvent for the precipitation. The results of the Hausner ratio, Carr’s index and angle of repose were found to be 0.94, 6.25, and 0.14, respectively, which revealed that the powder is free-flowing with good flowability. The gum was investigated for purity by carrying out chemical tests for different phytochemical constituents and only carbohydrates were found to be present. The swelling index was found to be 87 ± 1%, which shows that TGP has good water intake capacity. The pH of the 1% gum solution was found to be neutral, approximately 6.70 ± 0.01. The ash values such as total ash, sulphated ash, acid insoluble ash, and water-soluble ash were found to be 14.00 ± 1.00%, 13.00 ± 0.05%, 14.04 ± 0.57% and 7.29 ± 0.06%, respectively. The IR spectra confirmed the presence of alcohol, amines, ketones, anhydrides groups. The contact angle was <90°, indicating favorable wetting and good spreading of liquid over the surface The scanning electron micrograph (SEM) revealed that the particle is spherical in shape and irregular. DSC analysis shows a sharp exothermic peak at 350 °C that shows its crystalline nature. The results of the evaluated properties showed that TGP has acceptable properties and can be used as a excipient to formulate dosage forms for biomedical applications.

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“…The TGP formed a heap of a pile on the surface from where the radius can be calculated. The angle of repose can be determined using Equation (6).…”

Section: Powder Flow Propertymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluation and Characterization of Tamarind Gum Polysaccharide: The Biopolymer

et al. 2021

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“…TG has a dull color and unpleasant odor. Its insolubility in water and degradation in an aqueous environment has forced the scientists to chemically modify its functional groups [46] . Various modifications which have been executed till date include carboxymethylation [47] , acetylation [48] , hydroxylalkylation [49] and thiolisation [50,51] .…”

Section: Chemical Modification Of Tgmentioning

confidence: 99%

Delivery of drugs using tamarind gum and modified tamarind gum: A review

Mali¹,

Dhawale²,

Dias³

et al. 2019

Bulletin of Faculty of Pharmacy, Cairo University

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Tamarind seed polysaccharide is an emerging excipient, which is being used and investigated for the preparation of various dosage forms. Functionalization of tamarind gum (TG) enhances the properties of native tamarind polysaccharide like degradability, hydration, viscosity and swelling. Due to these excellent properties, researchers investigated the application of modified TG in various drug delivery systems. TG and modified TG are found to be appropriate for the designing of oral, nasal, ophthalmic, colonic and topical drug delivery systems. Moreover, they are used in the preparation of hydrogel-based drug delivery systems and novel drug delivery systems such as nanoparticles. Considering the above facts, additional research work is required to confirm the pharmaceutical uses of TG and modified TG in drug delivery. The current review deals with a comprehensive and valuable discussion on pharmaceutical applications of TG and modified TG.

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“…Due to these properties, TGP is widely used as a stabilizer, thickener, binder, release retardant, modifier, suspending agent, viscosity enhancer, emulsifying agent [33]. The recent works also shown the use of TGP as oral, buccal, colon, ocular and nano drug delivery systems [34].…”

Section: Introductionmentioning

confidence: 99%