Functionalization of β-cyclodextrin metal-organic frameworks with gelatin and glutamine for drug delivery of curcumin to cancerous cells

Sadeh, Pegah; Zeinali, Sedigheh; Rastegari, Banafsheh; Najafipour, Iman

doi:10.1016/j.heliyon.2024.e30349

Cited by 2 publications

(2 citation statements)

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“…Pegah Sadeh et al, investigated the functionalization of β-Cyclodextrin MOF for drug delivery to cancer cells and utilized MCF, AGS, and NIH/3T3 cell lines to evaluate the efficacy of the DDS. Cell viability was assessed using the MTT assay to determine the cytotoxicity and efficiency of various formulations (β-CD-MOF@CCM, glutamine-β-CD-MOF@ CCM, CCM-β-CD-MOF, GNPs, and Gelatin-β-CD-MOF@CCM) over a 72-h period (Sadeh et al, 2024). Tang's et al, created MOF-2 with Cu (II) being the active center as well as porphyrin ligand acting as the PSs, that absorbed GSH and precisely binding with Cu (II), leading to a reduction in intracellular GSH concentration.…”

Section: Photodynamic Therapymentioning

confidence: 99%

Section: Applications Of Mofs In Cancer Drug Deliverymentioning

confidence: 99%

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MOFs for next-generation cancer therapeutics through a biophysical approach—a review

Shano,

Karthikeyan,

Kennedy

et al. 2024

Front. Bioeng. Biotechnol.

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Metal-organic frameworks (MOFs) have emerged as promising nanocarriers for cancer treatment due to their unique properties. Featuring high porosity, extensive surface area, chemical stability, and good biocompatibility, MOFs are ideal for efficient drug delivery, targeted therapy, and controlled release. They can be designed to target specific cellular organelles to disrupt metabolic processes in cancer cells. Additionally, functionalization with enzymes mimics their catalytic activity, enhancing photodynamic therapy and overcoming apoptosis resistance in cancer cells. The controllable and regular structure of MOFs, along with their tumor microenvironment responsiveness, make them promising nanocarriers for anticancer drugs. These carriers can effectively deliver a wide range of drugs with improved bioavailability, controlled release rate, and targeted delivery efficiency compared to alternatives. In this article, we review both experimental and computational studies focusing on the interaction between MOFs and drug, explicating the release mechanisms and stability in physiological conditions. Notably, we explore the relationship between MOF structure and its ability to damage cancer cells, elucidating why MOFs are excellent candidates for bio-applicability. By understanding the problem and exploring potential solutions, this review provides insights into the future directions for harnessing the full potential of MOFs, ultimately leading to improved therapeutic outcomes in cancer treatment.

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Section: Photodynamic Therapymentioning

confidence: 99%

Section: Applications Of Mofs In Cancer Drug Deliverymentioning

confidence: 99%