Functionalization strategies of electrospun nanofibrous scaffolds for nerve tissue engineering

Qian, Jiaqi; Lin, Zhe; Liu, Yanyun; Wang, Ziyi; Lin, Yandai; Gong, Chenchi; Ruan, Renjie; Zhang, Jin; Yang, Huanghao

doi:10.1016/j.smaim.2021.07.006

Cited by 30 publications

(25 citation statements)

References 190 publications

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“…There are many techniques used to prepare NFs, including phase separation, self-assembly, template synthesis, melt is blown, etc. [177,204,205]. Each method has its limitations.…”

Section: Nanofibrous Scaffolds (Nfs)mentioning

confidence: 99%

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Conventional and Recent Trends of Scaffolds Fabrication: A Superior Mode for Tissue Engineering

ElMeligy

2022

Pharmaceutics

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Tissue regeneration is an auto-healing mechanism, initiating immediately following tissue damage to restore normal tissue structure and function. This falls in line with survival instinct being the most dominant instinct for any living organism. Nevertheless, the process is slow and not feasible in all tissues, which led to the emergence of tissue engineering (TE). TE aims at replacing damaged tissues with new ones. To do so, either new tissue is being cultured in vitro and then implanted, or stimulants are implanted into the target site to enhance endogenous tissue formation. Whichever approach is used, a matrix is used to support tissue growth, known as ‘scaffold’. In this review, an overall look at scaffolds fabrication is discussed, starting with design considerations and different biomaterials used. Following, highlights of conventional and advanced fabrication techniques are attentively presented. The future of scaffolds in TE is ever promising, with the likes of nanotechnology being investigated for scaffold integration. The constant evolvement of organoids and biofluidics with the eventual inclusion of organ-on-a-chip in TE has shown a promising prospect of what the technology might lead to. Perhaps the closest technology to market is 4D scaffolds following the successful implementation of 4D printing in other fields.

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“…There are many techniques used to prepare NFs, including phase separation, self-assembly, template synthesis, melt is blown, etc. [177,204,205]. Each method has its limitations.…”

Section: Nanofibrous Scaffolds (Nfs)mentioning

confidence: 99%

“…Various biomaterials are suited for NFs manufacturing using the electrospinning technique. These include natural polymers such as collagen and CS, synthetic polymers such as PCL, PLA and PGLA, and biocomposites such as CS/ PCL and CS/SF [205].…”

Section: Nanofibrous Scaffolds (Nfs)mentioning

confidence: 99%

Conventional and Recent Trends of Scaffolds Fabrication: A Superior Mode for Tissue Engineering

ElMeligy

2022

Pharmaceutics

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“…10 Although current clinical RA treatment agents including non-steroidal anti-inflammatory drugs for inhibiting the inflammatory cascade, disease-modifying antirheumatic drugs for slowing disease progression, or biological agents for antagonizing inflammatory cytokines can alleviate symptoms, there can be long-term drug dependence and considerable side effects. 11 To promote the course of RA from inflammation to resolution and ultimately terminate the vicious cycle of recrudescence, it is important to regulate the pro-/anti-inflammatory abilities of macrophages for constructing an immunosuppressive or anti-inflammatory microenvironment. 12–15…”

Section: Introductionmentioning

confidence: 99%

“…10 Although current clinical RA treatment agents including nonsteroidal anti-inflammatory drugs for inhibiting the inflammatory cascade, disease-modifying antirheumatic drugs for slowing disease progression, or biological agents for antagonizing inflammatory cytokines can alleviate symptoms, there can be long-term drug dependence and considerable side effects. 11 To promote the course of RA from inflammation to resolution and a Department of Ultrasound, National Clinical Research Center for Geriatrics, ultimately terminate the vicious cycle of recrudescence, it is important to regulate the pro-/anti-inflammatory abilities of macrophages for constructing an immunosuppressive or antiinflammatory microenvironment. [12][13][14][15] To construct the immunosuppressive or anti-inflammatory microenvironment, multifarious nanocarriers with enhanced permeability and retention abilities have been developed to load and deliver drugs to the inflammatory synovial site.…”

Section: Introductionmentioning

confidence: 99%

Ultrasound-augmented anti-inflammatory exosomes for targeted therapy in rheumatoid arthritis

Tang

Guo

et al. 2022

J. Mater. Chem. B

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“…By an immersion precipitation process, the introduction of a non‐solvent can effect phase separation of a polymer solution, followed by subsequent gelation or vitrification processes to freeze the microporous structure. The electrospinning is a unique process to produced submicron polymeric fibers in the nano‐ to micrometer range and are similar in size scale to element of the native extracellular matrix (ECM) 31 …”

Section: Introductionmentioning

confidence: 99%

Microstructure, thermal and rheological properties of poly(L‐lactide‐co‐ε‐caprolactone) tapered block copolymer for potential use in biomedical applications

Saeheng

Fuongfuchat

Sriyai

et al. 2022

J of Applied Polymer Sci

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This work investigates the thermal and rheological properties of the poly(L-lactide-co-ε-caprolactone), PLC, tapered block copolymer synthesized by ringopening polymerization (ROP) using stannous octoate (Sn [Oct] 2 ) as an initiator. The PLC copolymer (LL: CL = 48.9:51.1 mol% from 1 H-NMR) was obtained as a transparent, elastomeric material with a tapered monomer sequencing (R = 0.38 from 13 C-NMR data) due to randomizing effect of transesterification. The M n , M w , and Đ M of the PLC copolymer from GPC are 8.04 Â 10 4 , 1.36 Â 10 5 , and 1.69 respectively. The obtained moduli of the copolymer at 100% and 300% strain are rather low at 0.91 and 1.16 MPa. The rheological properties of the PLC melt are studied in terms of steady and oscillatory shear flow. The master curves at a reference temperature of 150 C with 5% and 100% strain suggest that the copolymer melt may contain some regular microstructures, such as small crystalline domains of poly(L-lactide), which remained intact at high strain deformation. The flow curve of the PLC melt at 150 C constructed from a cross model shows a Newtonian viscosity (η 0 ) of 6754 Pa-s, a consistency index (k) of 0.59, and a Power Law index of 0.35 where the onset of Power Law behavior is observed at around 10 s À1 . For the fabrication of the PLC nerve tubes, the best result is observed from the extruded PLC tubes with a combination of PEG porosifying agent leaching and phase immersion precipitation at 2 C using DMF/1,4-dioxane (1:1) as a mixed solvent and ethanol/chloroform (9:1) as a non-solvent. The porous tube obtained under this condition has a pore diameter and pore depth of approximately 2.3-2.5 and 30 μm respectively.

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Functionalization strategies of electrospun nanofibrous scaffolds for nerve tissue engineering

Cited by 30 publications

References 190 publications

Conventional and Recent Trends of Scaffolds Fabrication: A Superior Mode for Tissue Engineering

Conventional and Recent Trends of Scaffolds Fabrication: A Superior Mode for Tissue Engineering

Ultrasound-augmented anti-inflammatory exosomes for targeted therapy in rheumatoid arthritis

Microstructure, thermal and rheological properties of poly(L‐lactide‐co‐ε‐caprolactone) tapered block copolymer for potential use in biomedical applications

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