Functionalized 2D nanomaterials with switchable binding to investigate graphene–bacteria interactions

Tan, Kok H.; Sattari, Shabnam; Donskyi, Ievgen S.; Cuellar-Camacho, José Luis; Cheng, Chong; Schwibbert, Karin; Lippitz, Andreas; Unger, Wolfgang; Gorbushina, Anna A.; Adeli, Mohsen; Haag, Rainer

doi:10.1039/c8nr01347k

Cited by 48 publications

(33 citation statements)

References 67 publications

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“…Although GS NSs were chosen as a typical 2D NM for this study, more 2D NMs should be similarly screened for their antibacterial potential. Chemical modifications may also influence the antibacterial activity of 2D NMs . Adeli et al provided a new insight into the interactions between graphene and bacteria.…”

Section: Resultsmentioning

confidence: 99%

“…Owing to their exceptional physical and chemical properties, 2D nanomaterials (2D NMs) have attracted extensive attention in biomedical applications such as cancer phototherapy, biosensors, and antimicrobial activity . Many 2D NMs such as graphene and derivatives, black phosphorus, MoS 2 , and Ti 3 C 2 T x MXenes exhibit antibacterial activity, which substantially reduces the possible development of bacterial drug resistance. In this work, we developed new 2D GS NSs ( Figure a) with antibacterial properties.…”

Section: Introductionmentioning

confidence: 99%

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Anti‐Infective Application of Graphene‐Like Silicon Nanosheets via Membrane Destruction

Luo

Min

Han

et al. 2020

Adv Healthcare Materials

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The increasing problem of bacterial resistance to the currently effective antibiotics has resulted in the need for increasingly potent therapeutics to eradicate pathogenic microorganisms. 2D nanomaterials (2D NMs) have unique physical and chemical properties that make them attractive candidates for biomedical applications. Recently, the application of 2D NMs as antibacterial agents has attracted significant attention. Herein, a novel 2D graphene‐like silicon nanosheet (GS NS) antimicrobial agent is fabricated from pristine silicon crystals by ultrasonication, which results in a highly exfoliated planar morphology and a significantly larger surface area as compared with bulk silicon. The GS NSs exhibit remarkable in vitro broad‐spectrum bactericidal activity against Gram (−) Escherichia coli and Gram (+) Staphylococcus aureus because of a close interaction with the bacteria, which leads to highly efficient membrane destruction. The in vivo studies demonstrate that the local administration of GS NSs effectively mitigates implant‐related infection by reducing the bacterial burden of the extracted samples and accelerating the remission of local inflammation. Based on these encouraging results, GS NSs are expected to be a useful new member of the 2D NMs family, with the potential of effectively killing pathogenic bacteria in clinical applications.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Anti‐Infective Application of Graphene‐Like Silicon Nanosheets via Membrane Destruction

Luo

Min

Han

et al. 2020

Adv Healthcare Materials

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“…In another study [167], when bovine serum albumin (BSA) or tryptophan (Trp) molecules were noncovalently adsorbed on GO basal planes, the occupation could cause GO's deactivation against bacteria, suggesting the availability of GO basal planes in the cytotoxicity against bacteria. Recently, Haag et al [168] confirmed that the antimicrobial property of graphene was very relevant to both its sharp edges, basal planes and tight agglomeration by studying the interactions between functionalized graphene derivatives and bacteria.…”

Section: Mechanisms Of Antibacterial Activities Of Graphene-based Nanmentioning

confidence: 99%

Graphene-based nanomaterials in biosystems

Lü

Wang

et al. 2018

Nano Res.

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Graphene-based nanomaterials have emerged as a novel type of materials with exceptional physicochemical properties and numerous applications in various areas. In this review, we summarize recent advances in studying interactions between graphene and biosystems. We first provide a brief introduction on graphene and its derivatives, and then discuss on the toxicology and biocompatibility of graphene, including the extracellular interactions between graphene and biomacromolecules, cellular studies of graphene, and in vivo toxicological effects. Next, we focus on various graphene-based practical applications in antibacterial materials, wound addressing, drug delivery, and water purification. We finally present perspectives on challenges and future developments in these exciting fields.

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“…Zhang et al reported that cytotoxicity is size dependent of GO lateral dimension. [37] Nevertheless, antibacterial activity of GO is still controversial since contradictory studies can be found and discussed in the literature. [26] Likewise, antibacterial activity of GO (important to consider while designing pathogen biosensors) has been reported to be size-dependent, which may be able to compromise bacterial membrane integrity via oxidation stress, see Figure 2C.…”

Section: Lateral Sizementioning

confidence: 99%

Graphene Oxide as an Optical Biosensing Platform: A Progress Report

2018

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IntroductionAs a 2D material, graphene oxide (GO) is a lattice-like nanostructure of hexagonal carbon rings disrupted by oxygen-containing moieties. In 2012, we discussed the outstanding physicochemical properties offered by GO and how these features can be exploited in unprecedented optical biosensing systems. [1] In fact, GO can be processed in suspension, easily complexed with biomolecules, and offers a universal highly efficient long-range photoluminescence quenching agent-among other functional properties. Furthermore, we highlighted that GO photoluminescences with energy transfer donor/acceptor molecules exposed A few years ago, crucial graphene oxide (GO) features such as the carbon/oxygen ratio, number of layers, and lateral size were scarcely investigated and, thus, their impact on the overall optical biosensing performance was almost unknown. Nowadays valuable insights about these features are well documented in the literature, whereas others remain controversial. Moreover, most of the biosensing systems based on GO were amenable to operating as colloidal suspensions. Currently, the literature reports conceptually new approaches obviating the need of GO colloidal suspensions, enabling the integration of GO onto a solid phase and leading to their application in new biosensing devices. Furthermore, most GO-based biosensing devices exploit photoluminescent signals. However, further progress is also achieved in powerful label-free optical techniques exploiting GO in biosensing, particularly using optical fibers, surface plasmon resonance, and surface enhanced Raman scattering. Herein, a critical overview on these topics is offered, highlighting the key role of the physicochemical properties of GO. New challenges and opportunities in this exciting field are also highlighted.The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10.1002/adma.201805043.in a planar surface. [1] However, GO properties can be tailored according to its oxidation degree, lateral size, and number of layers, which was something little explored 6 years ago, and thus their impact on the overall biosensing performance was almost unknown. In addition, most of the biosensing systems based on GO were amenable to working as colloidal suspensions. Though, recent literature reports conceptually new approaches obviating the need of colloidal suspensions, which facilitates integration of GO-based biosensors into the solid phase and allows for their applications in new devices. Furthermore, the majority of the GO-based optical biosensing techniques rely on photoluminescent signals. However, further progress has also been achieved in powerful label-free optical techniques exploiting GO in biosensing. Here, we introduce a progress report on this exciting topic, underscoring challenges and opportunities in (bio)sensing accordingly. Number of LayersGO aqueous suspensions are highly stable in the form of mono layers. However, GO multilayer films can be built via

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Functionalized 2D nanomaterials with switchable binding to investigate graphene–bacteria interactions

Cited by 48 publications

References 67 publications

Anti‐Infective Application of Graphene‐Like Silicon Nanosheets via Membrane Destruction

Anti‐Infective Application of Graphene‐Like Silicon Nanosheets via Membrane Destruction

Graphene-based nanomaterials in biosystems

Graphene Oxide as an Optical Biosensing Platform: A Progress Report

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