Functionalized Dendrimers as Nanoscale Drug Carriers

Carbon Monoxide and Its Controlled Release: Therapeutic Application, Detection, and Development of Carbon Monoxide Releasing Molecules (CORMs)

“…Metallodendrimers are macromolecules with dendritic structures and a metal moiety, and they have emerged as promising CORM candidates because of their advantages, such as low polydispersity, good molecular uniformity, and defined structure as well as their ability to delivery large amounts of CO across cell membranes to cellular systems. − Govender et al described the first CO-releasing metallodendrimer, which combined the polypyridyl dendritic scaffolds with a Mn­(CO) 3 fragment to form a formula [DAB-PPI-{MnBr-(bpy CH3,CHN )­(CO) 3 } 4 ], [DAB = 1,4-diaminobutane, PPI = poly­(propyleneimine)]. This metallodendrimer was photoinducible and had a high CO-loading capacity.…”

Concurrent and Complete Anaerobic Reduction and Microaerophilic Degradation of Mono‐, Di‐, and Trichlorobenzenes

“…Since the ISMs are sterile when deployed, 13 C-enriched biomass, CO 2 , or methane provides evidence of in situ biodegradation of a target compound by indigenous organisms under actual aquifer conditions. SIP studies can be performed for any compound that microorganisms use as a carbon source, such as benzene, toluene, p-xylene, chlorobenzene, naphthalene, methyl tertiary butyl ether (MTBE), tertiary butyl alcohol (TBA), and 1,4-dioxane (Busch-Harris et al, 2006, 2008Chiang et al, 2012;Fiorenza et al, 2009;Geyer et al, 2005). In this study, 13 C from 13 C 6 -chlorobenzene was traced to DNA in an effort to identify microorganisms stimulated to degrade chlorobenzene by the remediation amendment EHC-M ® .…”

Evaluation of Toxicity of Nanostructures in Biological Systems

“…Due to their unique architecture (Figure 7.2), these branched polymers have a well-defined shape with many surface groups available for conjugation and/or interaction with biological systems. Of particular interest is the ability of PAMAM dendrimers to translocate across the epithelial barrier of the gastrointestinal (GI) tract for oral drug delivery applications (Kitchens et al, 2005;Kolhatkar et al, 2008). The potential toxicity of dendrimers as a function of their size (generation), charge and surface functionality remains a concern, however.…”