Functionalized formazans: A review on recent progress in their pharmacological activities

Shawali, Ahmad S.; Samy, Nevien

doi:10.1016/j.jare.2014.07.001

Cited by 45 publications

(24 citation statements)

References 62 publications

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“…[178,179] The biological importance of formazans was first recognised by pharmacolgical activities are due to the presence of hydrazo-azo bonds in their molecules.…”

Section: Biological Applications Of Formazansmentioning

confidence: 99%

“…The relationship between the general structural formulas [178] of various formazans and the biological activity they possess are summarised in Various substituted formazans are known to possess. antifertility activity, [180] antiinflammatory active, [181][182][183][184][185][186][187][188] antiviral activity, [189][190][191][192][193][194] anti-tubercular activity, [195][196][197] anticancer and anti HIV activities, [198][199][200][201][202] anticonvulsant activity, [203][204][205] anthelmintic activity, [206][207] antiparkinsonian activity, [208][209] cardiovascular activity, [210] antiproliferative activity, [211] analgesic activity [212] as markers of cell vitality and antioxidant activity [212][213][214][215][216][217][218][219][220][221]…”

Section: Biological Applications Of Formazansmentioning

confidence: 99%

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Frontiers of Formazans Chemistry: A Review

Kumar¹

2017

WJPR

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“…[178,179] The biological importance of formazans was first recognised by pharmacolgical activities are due to the presence of hydrazo-azo bonds in their molecules.…”

Section: Biological Applications Of Formazansmentioning

confidence: 99%

Section: Biological Applications Of Formazansmentioning

confidence: 99%

Frontiers of Formazans Chemistry: A Review

Kumar¹

2017

WJPR

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“…The azomethine and its derivatives have been considered as a protuberant research objects due to their significant complexometric behavior and pharmacological physiognomies . Azomethine derivatives perform noteworthy role by demonstrating numerous biological activities such as anticonvulsant, antiviral, antimicrobial, antioxidant, antitubercular, anticancer, anti‐HIV, anthelmintic and anti‐inflammatory.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, DFT, computational exploration of chemical reactivity, molecular docking studies of novel formazan metal complexes and their biological applications

Khan

Rızwan

Shahid

et al. 2020

Applied Organom Chemis

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The computational exploration of chemical reactivity and molecular docking of the synthesized formazan compounds (S1‐S6) were studied. Further, their antimicrobial activity against bacterial strains (S. epidermidis, B. cereus, K. pneumoniae and P. aeruginosa) and against fungal strains (T. mentagrophytes, C. albicans, A. niger, S. cerevisiae and C. glabrata) using agar diffusion method and antioxidant activity following DPPH inhibition assays were evaluated. Anticancer activity was executed in vitro model of human breast carcinoma (MCF‐7) cell line. The superior and enhanced antibacterial and antimycotic activities were exhibited by formazan compound (S4) by presenting maximum ZOIs and MICs values. While enhanced antioxidant in terms of percentage inhibition of DPPH and cytotoxic effect on human breast carcinoma‐cells demonstrated by formazan compound (S1) which was further validated by the results of molecular docking studies of (S1) with the human estrogen receptor protein. In order to compute quantum chemical reactivity descriptors from conceptual density functional theory (CDFT) point of view of this system, including chemical potential (μ), chemical hardness (η), electrophilicity (ω), condensed Fukui function and dual descriptors are calculated at the same level of calculation. The most active sites of these molecules are determined and correlated with experimental data. The present investigation displays that formazans compounds could be potential drug candidate that constrains the growth of microbial strains, possess ability to cause cytotoxic effect on carcinoma cells and act as effective scavenger for free radical species.

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“…BF 2 formazanate complexes meet these criteria and offer the ability to tune spectroscopic and electrochemical properties through structuralv ariation. [13] The parentf ormazans 2, [14] knownp rimarily for their use in cell viability assays, [15] are typically prepared using aryl diazoniumc oupling reactions in aqueous media. They exist in three differentc onformations (i.e.," closed", "open", or "linear") depending on the carbonbound substituent (R) present.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Anisole‐Substituted Boron Difluoride Formazanate Complexes for Fluorescence Cell Imaging

Maar

Barbon

Sharma

et al. 2015

Chemistry A European J

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Abstract:The evaluation of three subclasses of boron difluoride formazanate complexes bearing o-, m-, and p-anisole N-aryl substituents (Ar) as readily accessible alternatives to boron dipyrromethene (BODIPY) dyes for cell imaging applications is described. While the wavelengths of maximum absorption (max) and emission (em) observed for each subclass of complexes, which differed by their carbon-bound substituents (R), were similar, the emission quantum yields for 7ac (R = cyano) were enhanced relative to 8ac (R = nitro) and 9ac (R = phenyl). Complexes 7ac and 8ac were also significantly easier to reduce electrochemically to their radical anion and dianion forms compared to 9ac. Within each subclass, the o-substituted derivatives were more difficult to reduce, had shorter max and em, and lower emission quantum yields than the p-substituted analogs as a result of sterically-driven twisting of the N-aryl substituents and a decrease in the degree of  conjugation. The m-substituted complexes were the least difficult to reduce and possessed intermediate max, em, and quantum yields. The complexes studied also exhibited large Stokes shifts (82152 nm, 21435483 cm 1 ). Finally, the utility of complex 7c (Ar = panisole, R = cyano), which can be prepared for just a few dollars per gram, for fluorescence cell imaging was demonstrated. The use of 7c and 4',6-diamino-2-phenylindole (DAPI) allowed for simultaneous imaging of the cytoplasm and nucleus of mouse fibroblast cells.

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Functionalized formazans: A review on recent progress in their pharmacological activities

Abstract: Graphical abstract

Cited by 45 publications

References 62 publications

Frontiers of Formazans Chemistry: A Review

Frontiers of Formazans Chemistry: A Review

Synthesis, DFT, computational exploration of chemical reactivity, molecular docking studies of novel formazan metal complexes and their biological applications

Evaluation of Anisole‐Substituted Boron Difluoride Formazanate Complexes for Fluorescence Cell Imaging

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