Functionalized gold nanoparticles: a detailed in vivo multimodal microscopic brain distribution study

Sousa, Fernanda S. de; Mandal, Subhra; Garrovo, Chiara; Astolfo, Alberto; Bonifacio, Alois; Latawiec, Diane; Menk, R.H.; Arfelli, Fulvia; Huewel, Sabine; Legname, Giuseppe; Galla, Hans Joachim; Krol, Silke

doi:10.1039/c0nr00345j

Cited by 111 publications

(75 citation statements)

References 30 publications

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“…However, other studies on the effects of nanoparticles, have reported that other kinds of nanoparticles (like gold nanoparticles) injected into the tail vein of healthy mice show a biodistribution in the brain, and this has been characterized in detail. 15 One other study exposing rats to ZnO given daily (100 mg) via a gastric tube, showed morphological and histochemical changes in the brains of rats. 16 Based on these data, we assumed that nano-ZnO given intraperitoneally can cross the BBB and have influence on the brain.…”

Section: Animals and Treatmentmentioning

confidence: 99%

Nano-zinc oxide damages spatial cognition capability via over-enhanced long-term potentiation in hippocamus of Wistar rats

Han¹,

Tian²,

Zhang³

et al. 2011

IJN

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This study focused on the effects of zinc oxide nanoparticles (nano-ZnO) on spatial learning and memory and synaptic plasticity in the hippocampus of young rats, and tried to interpret the underlying mechanism. Rats were randomly divided into four groups. Nano-ZnO and phosphate-buffered saline were administered in 4-week-old rats for 8 weeks. Subsequently, performance in Morris water maze (MWM) was determined, and then long-term potentiation (LTP) and depotentiation were measured in the perforant pathway to dentate gyrus (DG) in anesthetized rats. The data showed that, (1) in MWM, the escape latency was prolonged in the nano-ZnO group and, (2) LTP was significantly enhanced in the nano-ZnO group, while depotentiation was barely influenced in the DG region of the nano-ZnO group. This bidirectional effect on long-term synaptic plasticity broke the balance between stability and flexibility of cognition. The spatial learning and memory ability was attenuated by the alteration of synaptic plasticity in nano-ZnO-treated rats.

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Section: Animals and Treatmentmentioning

confidence: 99%

Nano-zinc oxide damages spatial cognition capability via over-enhanced long-term potentiation in hippocamus of Wistar rats

Han¹,

Tian²,

Zhang³

et al. 2011

IJN

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“…For example, compared with hydrophobic NPs, hydrophilic nanocrystalline TiO 2 NPs exhibit a greater influence on the 5-HT and 5-HIAA monoamine levels in the subbrain regions. 137 Sousa et al 138 modified the 15 nm gold NP surface by coating with functional polyelectrolyte layers and human serum albumin and found that the modified gold NPs were able to pass the BBB and accumulate in neuronal or glial cells in specific regions close to the brain stem.…”

Section: Surface Modificationmentioning

confidence: 99%

Central nervous system toxicity of metallic nanoparticles

Feng¹,

Chen²,

Zhang³

et al. 2015

IJN

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Nanomaterials (NMs) are increasingly used for the therapy, diagnosis, and monitoring of disease- or drug-induced mechanisms in the human biological system. In view of their small size, after certain modifications, NMs have the capacity to bypass or cross the blood–brain barrier. Nanotechnology is particularly advantageous in the field of neurology. Examples may include the utilization of nanoparticle (NP)-based drug carriers to readily cross the blood–brain barrier to treat central nervous system (CNS) diseases, nanoscaffolds for axonal regeneration, nanoelectromechanical systems in neurological operations, and NPs in molecular imaging and CNS imaging. However, NPs can also be potentially hazardous to the CNS in terms of nano-neurotoxicity via several possible mechanisms, such as oxidative stress, autophagy, and lysosome dysfunction, and the activation of certain signaling pathways. In this review, we discuss the dual effect of NMs on the CNS and the mechanisms involved. The limitations of the current research are also discussed.

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“…The particles were investigated for their ability to cross the blood brain barrier by intravenous injection into mice. Ex vivo CT scans of the brain showed the highest CT signal was located at the thalamus and hypothalamus [105].…”

Section: Passively Targeted Gold Nanoparticle Formulationsmentioning

confidence: 99%

Gold Nanoparticles as X-Ray, CT, and Multimodal Imaging Contrast Agents: Formulation, Targeting, and Methodology

Mahan

Doiron

2018

Journal of Nanomaterials

116

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Computed tomography (CT) is among the most popular medical imaging modalities due to its high resolution images, fast scan time, low cost, and compatibility with all patients. CT scans of soft tissues require the localization of imaging contrast agents (CA) to create contrast, revealing anatomic information. Gold nanoparticles (AuNP) have attracted interest recently for their use as CT CA due to their high X-ray attenuation, simple surface chemistry, and biocompatibility. Targeting molecules may be attached to the particles to allow for the targeting of specific cell types and disease states. AuNP can also be readily designed to incorporate other imaging contrast agents such as rare earth metals and dyes. This review summarizes the current state-of-the-art knowledge in the field of AuNP used as X-ray and multimodal contrast agents. Primary research is analyzed through the lens of structure-propertyfunction to best explain the design of a particle for a given application. Design specification of particles includes size, shape, surface functionalization, composition, circulation time, and component synergy. Key considerations include delivery of a CA payload to the site of interest, nontoxicity of particle components, and contrast enhancement compared to the surrounding tissue. Examples from literature are included to illustrate the strategies used to address design considerations.

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Functionalized gold nanoparticles: a detailed in vivo multimodal microscopic brain distribution study

Cited by 111 publications

References 30 publications

Nano-zinc oxide damages spatial cognition capability via over-enhanced long-term potentiation in hippocamus of Wistar rats

Nano-zinc oxide damages spatial cognition capability via over-enhanced long-term potentiation in hippocamus of Wistar rats

Central nervous system toxicity of metallic nanoparticles

Gold Nanoparticles as X-Ray, CT, and Multimodal Imaging Contrast Agents: Formulation, Targeting, and Methodology

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