Functionalized graphene oxide as a drug carrier for loading pirfenidone in treatment of subarachnoid hemorrhage

Yang, Lijun; Wang, Feng; Han, Haie; Yang, Liang; Zhang, Gengshen; Fan, Zhimin

doi:10.1016/j.colsurfb.2015.03.022

Cited by 50 publications

(28 citation statements)

References 35 publications

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“…As result, Tf-PEG-GO-DOX nanoparticles can significantly delay the tumor growth and increase the rats median survival time, although no complete tumor eradication is noticed. Similarly, GO-PEG (100–300 nm lateral size) functionalized with Human Immunodeficiency Virus (HIV) Tat protein derived peptide (Tat), which increases the BBB permeability of the nanomaterial, can deliver drug molecules inside the brain tissues (Yang et al, 2015 ). The targeted nanovector is able to improve the perfenidone (PERF) efficacy in the treatment of subarachnoid hemorrhage, whose success is limited by the scarce BBB penetration of the drug.…”

Section: Graphene Oxide and Derived Nanomaterialsmentioning

confidence: 99%

Carbon Nanomaterials Interfacing with Neurons: An In vivo Perspective

et al. 2016

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Developing new tools that outperform current state of the art technologies for imaging, drug delivery or electrical sensing in neuronal tissues is one of the great challenges in neurosciences. Investigations into the potential use of carbon nanomaterials for such applications started about two decades ago. Since then, numerous in vitro studies have examined interactions between these nanomaterials and neurons, either by evaluating their compatibility, as vectors for drug delivery, or for their potential use in electric activity sensing and manipulation. The results obtained indicate that carbon nanomaterials may be suitable for medical therapies. However, a relatively small number of in vivo studies have been carried out to date. In order to facilitate the transformation of carbon nanomaterial into practical neurobiomedical applications, it is essential to identify and highlight in the existing literature the strengths and weakness that different carbon nanomaterials have displayed when probed in vivo. Unfortunately the current literature is sometimes sparse and confusing. To offer a clearer picture of the in vivo studies on carbon nanomaterials in the central nervous system, we provide a systematic and critical review. Hereby we identify properties and behavior of carbon nanomaterials in vivo inside the neural tissues, and we examine key achievements and potentially problematic toxicological issues.

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Section: Graphene Oxide and Derived Nanomaterialsmentioning

confidence: 99%

Carbon Nanomaterials Interfacing with Neurons: An In vivo Perspective

et al. 2016

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“…Pegylated GO nanoparticles treated with polyethylenimine and other polymers like chitosan, poly( N -isopropylacrylamide), polyacrylates, poly- l -lysine, poly(sodium 4-styrenesulfonate), dextran, pluronic, proteins, with small molecules like folic acid and cyclodextrins have been broadly applied as drug carriers [ 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 ]. In such work, a multifunctional system consisting of PEI/poly(sodium-4-styrenesulfonates) (PSS)/GO was prepared in order to evaluate its use as a delivery agent of adriamycin (ADR) along with miR-21 targeted siRNA in cancer drug resistance [ 76 ].…”

Section: Types Of Nanocarriersmentioning

confidence: 99%

Surface Modified Multifunctional and Stimuli Responsive Nanoparticles for Drug Targeting: Current Status and Uses

Sıafaka

Okur

Karavas

et al. 2016

IJMS

160

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Nanocarriers, due to their unique features, are of increased interest among researchers working with pharmaceutical formulations. Polymeric nanoparticles and nanocapsules, involving non-toxic biodegradable polymers, liposomes, solid lipid nanoparticles, and inorganic–organic nanomaterials, are among the most used carriers for drugs for a broad spectrum of targeted diseases. In fact, oral, injectable, transdermal-dermal and ocular formulations mainly consist of the aforementioned nanomaterials demonstrating promising characteristics such as long circulation, specific targeting, high drug loading capacity, enhanced intracellular penetration, and so on. Over the last decade, huge advances in the development of novel, safer and less toxic nanocarriers with amended properties have been made. In addition, multifunctional nanocarriers combining chemical substances, vitamins and peptides via coupling chemistry, inorganic particles coated by biocompatible materials seem to play a key role considering that functionalization can enhance characteristics such as biocompatibility, targetability, environmental friendliness, and intracellular penetration while also have limited side effects. This review aims to summarize the “state of the art” of drug delivery carriers in nanosize, paying attention to their surface functionalization with ligands and other small or polymeric compounds so as to upgrade active and passive targeting, different release patterns as well as cell targeting and stimuli responsibility. Lastly, future aspects and potential uses of nanoparticulated drug systems are outlined.

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“…Graphene, the best-known 2D nanomaterial, was first discovered in 2004 9 and has since been extensively tested for applications in electronics and optics 10, catalysis 11, sensors 12, energy storage 13 and biomedical devices 14. GO is a graphite oxide monolayer obtained by exfoliating graphite oxide into layered sheets which can then be dispersed in water thanks to abundant hydrophilic surface groups such as hydroxyl and carboxyl groups 15. These surface groups can easily be functionalized with biocompatible polyethylene glycol (PEG) polymers, which endow GO with high biocompatibility and loading capacity 16.…”

Section: Introductionmentioning

confidence: 99%

SiRNA Delivery with PEGylated Graphene Oxide Nanosheets for Combined Photothermal and Genetherapy for Pancreatic Cancer

Yin¹,

Hu²,

Chen³

et al. 2017

Theranostics

173

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Since the successful exfoliation of graphene from graphite in 2004, graphene and graphene oxide (GO) have been considered the most promising two-dimensional (2D) nanomaterials with distinguished physical and chemical characteristics and have attracted great attention in many different fields. Graphene oxide is well-known for its distinct physiochemical properties and shows only minimal cytotoxicity compared to carbon nanotubes. Until now, only limited efforts have been invested in utilizing GO for gene therapy in pancreatic cancer treatments. In this study, we utilized multi-functionalized monolayer GO as a gene delivery system to efficiently co-deliver HDAC1 and K-Ras siRNAs (small interfering RNAs targeting the HDAC1 gene and the G12C mutant K-Ras gene, respectively) to specifically target pancreatic cancer cells MIA PaCa-2. The systematic mechanistic elucidation of the dual gene silencing effects indicated the inactivation of both the HDAC1 and the K-Ras gene, thereby causing apoptosis, proliferation inhibition and cell cycle arrest in treated MIA PaCa-2 cells. The synergistic combination of gene silencing and NIR light thermotherapy showed significant anticancer efficacy, inhibiting in vivo tumor volume growth by >80%. Furthermore, GO can be metabolized in the mouse model within a reasonable period of time without obvious side effects. Based on preliminary in vivo application, this study for the first time indicates the promising potential of functionalized GO as a vehicle for gene therapy delivery with low toxicity for the treatment of pancreatic adenocarcinoma.

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Functionalized graphene oxide as a drug carrier for loading pirfenidone in treatment of subarachnoid hemorrhage

Cited by 50 publications

References 35 publications

Carbon Nanomaterials Interfacing with Neurons: An In vivo Perspective

Carbon Nanomaterials Interfacing with Neurons: An In vivo Perspective

Surface Modified Multifunctional and Stimuli Responsive Nanoparticles for Drug Targeting: Current Status and Uses

SiRNA Delivery with PEGylated Graphene Oxide Nanosheets for Combined Photothermal and Genetherapy for Pancreatic Cancer

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