Functionalized Lipid Nanoparticles–Cellophane Hybrid Films for Molecular Delivery: Preparation, Physicochemical Characterization, and Stability

Vázquez, M.I.; Peláez, Laura; Benavente, J.; López‐Romero, Juan Manuel; Rico, Rodrigo; Hierrezuelo, Jesús; Guillén, Elena; López-Ramírez, María Rosa

doi:10.1002/jps.22688

Cited by 8 publications

(2 citation statements)

References 31 publications

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“…1.5 mL) was decanted and the remaining solid was extracted with ethanol (7 mL at 80 °C) for 5 min. The ethanolic extract was centrifuged (3000 rpm, 5 min) to eliminate solids, and the supernatant filtered off and injected into the HPLC system for quantitatively determining the amount of PTX in the ethanol phase, which in turn allows an estimation of the PTX loading in the NPs 49 , 50 .…”

Section: Methodsmentioning

confidence: 99%

Tripalmitin nanoparticle formulations significantly enhance paclitaxel antitumor activity against breast and lung cancer cells in vitro

Leiva

Ortíz

Contreras‐Cáceres

et al. 2017

Sci Rep

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Paclitaxel (PTX) is one of the drugs of choice in the treatment of breast and lung cancer. However, its severe side effects, including mielosuppression, cardiotoxicity and neurotoxicity, frequently cause treatment to be discontinued. Solid lipid nanoparticles (NPs) of glyceril tripalmitate (tripalmitin) loaded with PTX (Tripalm-NPs-PTX) including modifications by the addition of hexa(ethylene glycol), β-cyclodextrin and macelignan were developed. All NPs-PTX formulations displayed excellent hemocompatibility and significantly enhanced PTX antitumor activity in human breast (MCF7, MDAMB231, SKBR3 and T47D) and lung (A549, NCI-H520 and NCI-H460) cancer cells. Tripalm-NPs-PTX decreased PTX IC50 by as much as 40.5-fold in breast and 38.8-fold in lung cancer cells and Tripalm-NPs-PTX macelignan inhibited P-glycoprotein in resistant tumor cells. In addition, Tripalm-NPs-PTX significantly decreased the volume of breast and lung multicellular tumor spheroids that mimics in vivo tumor mass. Finally, Tripalm-NPs-PTX decreased the PTX IC50 of cancer stem cells (CSCs) derived from both lung and breast cancer cells (6.7- and 14.9-fold for MCF7 and A549 CSCs, respectively). These results offer a new PTX nanoformulation based on the use of tripalmitin which improves the antitumor activity of PTX and that may serve as an alternative PTX delivery system in breast and lung cancer treatment.

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Section: Methodsmentioning

confidence: 99%

Tripalmitin nanoparticle formulations significantly enhance paclitaxel antitumor activity against breast and lung cancer cells in vitro

Leiva

Ortíz

Contreras‐Cáceres

et al. 2017

Sci Rep

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“…One of the points of interest in our research is the inclusion/immobilization of pharmacologically active molecules on solid substrates and the study of their interactions with permeable solutes [21,22]. Particularly, in this paper we present the results on functionalization of membrane surfaces with compound Theo1 and its interaction with Atto-565-streptavidin conjugate, a biotin-binding protein.…”

Section: Introductionmentioning

confidence: 98%

Membrane surface functionalization via theophylline derivative coating and streptavidin immobilization

Hierrezuelo¹,

Romero²,

Benavente³

et al. 2014

Colloids and Surfaces B: Biointerfaces

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Hybrid Regenerated Cellulose/Loaded Lipid Nanoparticle Membranes: Preparation and Characterization

Benavente¹,

López‐Romero²

2014

Encyclopedia of Membranes

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Functionalized Lipid Nanoparticles–Cellophane Hybrid Films for Molecular Delivery: Preparation, Physicochemical Characterization, and Stability

Cited by 8 publications

References 31 publications

Tripalmitin nanoparticle formulations significantly enhance paclitaxel antitumor activity against breast and lung cancer cells in vitro

Tripalmitin nanoparticle formulations significantly enhance paclitaxel antitumor activity against breast and lung cancer cells in vitro

Membrane surface functionalization via theophylline derivative coating and streptavidin immobilization

Hybrid Regenerated Cellulose/Loaded Lipid Nanoparticle Membranes: Preparation and Characterization

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