Functionalized mesoporous silica-coated magnetic graphene oxide by polyglycerol-g-polycaprolactone with pH-responsive behavior: Designed for targeted and controlled doxorubicin delivery

Pourjavadi, Ali; Tehrani, Zahra Mazaheri; Jokar, Safura

doi:10.1016/j.jiec.2015.01.021

Cited by 51 publications

(23 citation statements)

References 51 publications

(47 reference statements)

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“…It is possible to go further and combine these two different types of storage interactions by synthesizing mesoporous nanoparticles that combine both silica and carbon moieties [ 51 ]. Hybrid core-shell magnetic mesoporous nanoparticles with silica or carbon shell have also been reported [ 52 , 53 , 54 ], thus providing nanocarriers with not only the above-mentioned storage properties of MSNs and MCNs, but also promising applications in hyperthermia, photothermal therapy or imaging.…”

Section: Host-guest Interactionsmentioning

confidence: 99%

pH-Responsive Mesoporous Silica and Carbon Nanoparticles for Drug Delivery

2017

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The application of nanotechnology to medicine constitutes a major field of research nowadays. In particular, the use of mesoporous silica and carbon nanoparticles has attracted the attention of numerous researchers due to their unique properties, especially when applied to cancer treatment. Many strategies based on stimuli-responsive nanocarriers have been developed to control the drug release and avoid premature release. Here, we focus on the use of the subtle changes of pH between healthy and diseased areas along the body to trigger the release of the cargo. In this review, different approximations of pH-responsive systems are considered: those based on the use of the host-guest interactions between the nanocarriers and the drugs, those based on the hydrolysis of acid-labile bonds and those based on supramolecular structures acting as pore capping agents.

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Section: Host-guest Interactionsmentioning

confidence: 99%

pH-Responsive Mesoporous Silica and Carbon Nanoparticles for Drug Delivery

2017

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“…CCDP‐q‐[PEG‐g‐poly(DMA‐co‐MAA)] (C‐PDM, Mn:13,200) was synthesized, following a method similar to our previous work . To prepare the spiropyran conjugated CCDP‐q‐[PEG‐g‐poly(DMA‐co‐MAA)] (C‐PDM), 0.177 g of spiropyran was mixed with 3 g of C‐PDM by reaction with equimolar equivalents of DMAP (0.071 g) and DCC (0.12 g) in dry dichloromethane (70 mL).…”

Section: Methodsmentioning

confidence: 99%

Photo‐switchable spiropyran immobilized polystyrene beads using catechol chemistry

Kang

Cho

Islamy

et al. 2017

Surface & Interface Analysis

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Catechol and spiropyran functional groups were conjugated to a polymer backbone, allowing immobilization on polystyrene beads (PS beads). The final product was capable of stably reproducing the optical properties of spiropyran. Through the outstanding surface adhesion properties of the catechol functional group, spiropyran was immobilized on PS beads. Switchable photoluminescence in the spiropyran coated PS bead surfaces was observed depending on irradiation with either UV or visible light. The surfaces of the PS beads were morphologically examined by field emission scanning electron microscopy and X-ray photoelectron spectroscopy was used for characterization of the constituent atoms. Furthermore, UV-Vis and fluorescence spectroscopy were used to confirm conversion between the spiropyran (SP) and merocyanine (MC) forms through UV or visible light irradiation on SP, while fluorescent images for both SP and MC were studied using confocal laser scanning microscopy. The confocal images of the SP-PS beads system onto MDAMB-231 cells under UV and visible light indicate the cellular uptake by emerging color within the cytoplasm. Advancing study, the remaining catechol groups can confers adhesive properties, given by contact angle data of various coated surfaces film. These stimuli-responsive coatings are compatible as drawing switchable photochromic material on versatile substrate shown in confocal images of propylene film. Overall, this great water solubility and biocompatibility PS beads system also showed potential as cell bio-imaging light stimuli responsive material, and the benefits of this system can also possibly address coat able advanced material for a wide range of surface light sensor applications.

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“…GF or GO can be used either alone or in hybrids or mixtures with other nanoparticles. In a recent work, polyglycerol-g-polycaprolactone copolymers were grafted on mesoporous silica-coated magnetic graphene oxide complex [ 80 ]. DOX was loaded on this carrier as an anticancer drug and from in vitro DOX release studies demonstrated a controlled pH responsive behaviour.…”

Section: Types Of Nanocarriersmentioning

confidence: 99%

Surface Modified Multifunctional and Stimuli Responsive Nanoparticles for Drug Targeting: Current Status and Uses

Sıafaka

Okur

Karavas

et al. 2016

IJMS

160

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Nanocarriers, due to their unique features, are of increased interest among researchers working with pharmaceutical formulations. Polymeric nanoparticles and nanocapsules, involving non-toxic biodegradable polymers, liposomes, solid lipid nanoparticles, and inorganic–organic nanomaterials, are among the most used carriers for drugs for a broad spectrum of targeted diseases. In fact, oral, injectable, transdermal-dermal and ocular formulations mainly consist of the aforementioned nanomaterials demonstrating promising characteristics such as long circulation, specific targeting, high drug loading capacity, enhanced intracellular penetration, and so on. Over the last decade, huge advances in the development of novel, safer and less toxic nanocarriers with amended properties have been made. In addition, multifunctional nanocarriers combining chemical substances, vitamins and peptides via coupling chemistry, inorganic particles coated by biocompatible materials seem to play a key role considering that functionalization can enhance characteristics such as biocompatibility, targetability, environmental friendliness, and intracellular penetration while also have limited side effects. This review aims to summarize the “state of the art” of drug delivery carriers in nanosize, paying attention to their surface functionalization with ligands and other small or polymeric compounds so as to upgrade active and passive targeting, different release patterns as well as cell targeting and stimuli responsibility. Lastly, future aspects and potential uses of nanoparticulated drug systems are outlined.

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Functionalized mesoporous silica-coated magnetic graphene oxide by polyglycerol-g-polycaprolactone with pH-responsive behavior: Designed for targeted and controlled doxorubicin delivery

Cited by 51 publications

References 51 publications

pH-Responsive Mesoporous Silica and Carbon Nanoparticles for Drug Delivery

pH-Responsive Mesoporous Silica and Carbon Nanoparticles for Drug Delivery

Photo‐switchable spiropyran immobilized polystyrene beads using catechol chemistry

Surface Modified Multifunctional and Stimuli Responsive Nanoparticles for Drug Targeting: Current Status and Uses

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