Functionalized mesoporous silica materials for controlled drug delivery

Yang, Piaoping; Gai, Shili; Lin, Jun

doi:10.1039/c2cs15308d

Cited by 1,304 publications

(845 citation statements)

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“…Mesoporous silica nanoparticles (MSN) have been widely investigated as drug delivery vehicles [65]- [69] with their main benefit compared to nonporous nanoparticles being the higher surface available for drug loading. When surface conjugation or adsorption is carried out, the drug release kinetics is unlikely to depend on the presence of pores and the conclusions of our study can be translated to mesoporous silica nanoparticles.…”

Section: Discussionmentioning

confidence: 99%

Controlling release kinetics of gentamicin from silica nano-carriers

Perni

Martini-Gilching

Prokopovich

2018

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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Antibiotic release from a carrier can be employed to reduce the frequency of administration or prolong efficacy. In this work, we prepared silica nanoparticles loaded with gentamicin through different synthetis routes (entrapment, adsorption, covalent bonding and Layer-by-Layer (LbL) techniques). The nanocarriers physical-chemical properties were characterised and antibiotic release from the nanocarriers was monitored. The nanoparticles prepared entrapping gentamicin gave the highest drug load but completed the release over a period of 4 hours. No significant differences in antibiotic load were noticed between absorption or binding of gentamicin onto the silica nanoparticles surface; moreover the release of the drug occurred over 2 days. The nanoparticles coated with gentamicin through LbL technique released the antibiotic for 3 weeks. This work demonstrates that silica nanoparticles can be employed as antibiotic carriers providing a continuous release of antibiotic over a period that can be tuned through the choice of preparation method.

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Section: Discussionmentioning

confidence: 99%

Controlling release kinetics of gentamicin from silica nano-carriers

Perni

Martini-Gilching

Prokopovich

2018

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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“…Mesoporous silica nanocarriers (MSNs) are one of the most promising nanomaterials for drug delivery in nanomedicine because of their outstanding features, such as easy synthesis, tunable size, tailorable pore volume, and highly versatile surface (Lu et al 2010;Yang, Gai, and Lin 2012). Silanol groups present on the surface of MSNs can be functionalized with various ligands, which could be one way of controlling nanoparticle (NP) biodistribution and the design of specific targeted delivery systems (Bouchoucha et al 2016;Li et al 2016).…”

Section: Introductionmentioning

confidence: 99%

Biocompatibility assessment of functionalized magnetic mesoporous silica nanoparticles in human HepaRG cells

et al. 2017

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Magnetic mesoporous silica nanoparticles (M-MSNs) are a promising class of nanoparticles for drug delivery. However, a deep understanding of the toxicological mechanisms of action of these nanocarriers is essential, especially in the liver. The potential toxicity on HepaRG cells of pristine, pegylated (PEG), and lipid (DMPC) M-MSNs were compared. Based on MTT assay and real-time cell impedance, none of these NPs presented an extensive toxicity on hepatic cells. However, we observed by transmission electron microscopy (TEM) that the DMPC and pristine M-MSNs were greatly internalized. In comparison, PEG M-MSNs showed a slower cellular uptake. Whole gene expression profiling revealed the M-MSNs molecular modes of action in a time-and dose-dependent manner. The lowest dose tested (1.6 mg/cm 2 ) induced no molecular effect and was defined as 'No Observed Transcriptional Effect level.' The dose 16 mg/cm 2 revealed nascent but transient effects. At the highest dose (80 mg/cm 2 ), adverse effects have clearly arisen and increased over time. The limit of biocompatibility for HepaRG cells could be set at 16 mg/cm 2 for these NPs. Thanks to a comparative pathway-driven analysis, we highlighted the sequence of events that leads to the disruption of hepatobiliary system, elicited by the three types of MMSNs, at the highest dose. The Adverse Outcome Pathway of hepatic cholestasis was implicated. Toxicogenomics applied to cell cultures is an effective tool to characterize and compare the modes of action of many substances. We propose this strategy as an asset for upstream selection of the safest nanocarriers in the framework of regulation for nanobiosafety. ARTICLE HISTORY

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“…1,2 For example, significant R&D resources have been devoted to nanoparticle technology in diverse fields including electronic and biomedical devices, automotive parts, coatings, drug delivery, gene delivery, catalysis and polymers. [3][4][5][6][7][8][9][10][11][12][13][14] For several of these applications surface functionalization is an important requirement. For example, to change the polarity of the nanoparticles and promote dispersion in organic solvents or polymers chemical treatment by cation exchange or grafting using organosilanes has been extensively practiced.…”

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confidence: 99%

An improved process for the surface modification of SiO2 nanoparticles

Livi

Giannelis

2012

Green Chem.

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A phosphonium ionic liquid is used as an activator of silanol groups to improve the surface functionalization of silica nanoparticles with fluorosilanes in supercritical CO 2 .Due to their excellent optical, electrical and mechanical properties as well as their unique advantages such as high surface area, nanoparticles can play a key role in many nanotechnology applications. 1,2 For example, significant R&D resources have been devoted to nanoparticle technology in diverse fields including electronic and biomedical devices, automotive parts, coatings, drug delivery, gene delivery, catalysis and polymers. [3][4][5][6][7][8][9][10][11][12][13][14] For several of these applications surface functionalization is an important requirement. For example, to change the polarity of the nanoparticles and promote dispersion in organic solvents or polymers chemical treatment by cation exchange or grafting using organosilanes has been extensively practiced. [15][16][17] In addition, surface functionalization has been used to improve the stability of the nanoparticles and avoid aggregation in various media. 18,19 Surface functionalization is typically carried out in the presence of organic solvents. In some instances and to make the process greener, supercritical CO 2 (scCO 2 ) has been used in place of conventional solvents. However, the grafting density tends to be relatively low. It has been reported that small amounts of a highly basic ionic liquid (<0.5 wt%) can generate silanoates on the surface of silica. We combine here the use of an ionic liquid in scCO 2 to increase the grafting density of fluorosilane on silica. The process results in doubling of the grafting densities with the resulting nanoparticles exhibiting CO 2 -philic behavior. In addition to the increased reactivity and higher grafting density the new process offers the following additional advantages: (i) this is a one-step process, (ii) the use of organic solvents is completely eliminated, (iii) the lengthy steps of purification and drying of the silica are replaced by dilution and filtration, (iv) the ionic liquid can be recovered and reused.We note that our process differs from previous reports using scCO 2 in that low pressures (80 instead of 400 bar) and less amounts of silane (only 10 wt% compared to a 3-10 times molar excess of the corresponding coupling agents used in the literature) are required. 20,21 In addition, previous reports utilizing scCO 2 were limited to dry, fumed silica instead of aqueous dispersions used in our approach. While the primary particles of fumed silica are small and comparable to that of colloidal silica, drying tends to lead to particle agglomeration.While the method can be applicable to different oxides we demonstrate it here using colloidal silica and three different fluorosilanes: (i) perfluorooctyl-methyldimethoxysilane (DMS), (ii) perfluorooctyl-trichlorosilane (TCS), and (iii) perfluorooctyltriethoxysilane (TES). Triphenyloctadecyltriphenylphosphonium iodide (C 18 P I − ) was used as the surface activator. The synthesi...

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Functionalized mesoporous silica materials for controlled drug delivery

Cited by 1,304 publications

References 250 publications

Controlling release kinetics of gentamicin from silica nano-carriers

Controlling release kinetics of gentamicin from silica nano-carriers

Biocompatibility assessment of functionalized magnetic mesoporous silica nanoparticles in human HepaRG cells

An improved process for the surface modification of SiO2 nanoparticles

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