Functionalized mesoporous silica nanoparticles and biomedical applications

Thi, Thai Thanh Hoang; Cao, Van Du; Nguyen, Thi Nhu Quynh; Hoang, Duc Thuan; Ngo, Van Cuong; Nguyen, Dai Hai

doi:10.1016/j.msec.2019.01.129

Cited by 161 publications

(78 citation statements)

References 249 publications

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“…SiNPs may naturally exist or be added to products by humans during fabrication or manufacturing. SiNPs have wide applications because of their unique properties and have been used in fields such as microelectronics [2], material science and industry [3], agriculture, food and consumer products (including cosmetics) [4][5][6][7], and medicine (drug delivery, diagnostic and medicine imaging and engineering) [8,9]. However, large-scale industrial SiNPs production and global SiNPs commercialization have increased human exposure risks [10].…”

Section: (Continued From Previous Page)mentioning

confidence: 99%

Silica nanomaterials induce organ injuries by Ca2+-ROS-initiated disruption of the endothelial barrier and triggering intravascular coagulation

Wang

Zhao

et al. 2020

Part Fibre Toxicol

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Background: The growing use of silica nanoparticles (SiNPs) in many fields raises human toxicity concerns. We studied the toxicity of SiNP-20 (particle diameter 20 nm) and SiNP-100 (100 nm) and the underlying mechanisms with a focus on the endothelium both in vitro and in vivo. Methods:The study was conducted in cultured human umbilical vein endothelial cells (HUVECs) and adult female Balb/c mice using several techniques.Results: In vitro, both SiNP-20 and SiNP-100 decreased the viability and damaged the plasma membrane of cultured HUVECs. The nanoparticles also inhibited HUVECs migration and tube formation in a concentrationdependent manner. Both SiNPs induced significant calcium mobilization and generation of reactive oxygen species (ROS), increased the phosphorylation of vascular endothelial (VE)-cadherin at the site of tyrosine 731 residue (pY731-VEC), decreased the expression of VE-cadherin expression, disrupted the junctional VE-cadherin continuity and induced F-actin re-assembly in HUVECs. The injuries were reversed by blocking Ca 2+ release activated Ca 2+ (CRAC) channels with YM58483 or by eliminating ROS with N-acetyl cysteine (NAC). In vivo, both SiNP-20 and SiNP-100 (i.v.) induced multiple organ injuries of Balb/c mice in a dose (range 7-35 mg/kg), particle size, and exposure time (4-72 h)-dependent manner. Heart injuries included coronary endothelial damage, erythrocyte adhesion to coronary intima and coronary coagulation. Abdominal aorta injury exhibited intimal neoplasm formation. Lung injuries were smaller pulmonary vein coagulation, bronchiolar epithelial edema and lumen oozing and narrowing. Liver injuries included multifocal necrosis and smaller hepatic vein congestion and coagulation. Kidney injuries involved glomerular congestion and swelling. Macrophage infiltration occurred in all of the observed organ tissues after SiNPs exposure. SiNPs also decreased VE-cadherin expression and altered VE-cadherin spatial distribution in multiple organ tissues in vivo. The largest SiNP (SiNP-100) and longest exposure time exerted the greatest toxicity both in vitro and in vivo.

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Section: (Continued From Previous Page)mentioning

confidence: 99%

Silica nanomaterials induce organ injuries by Ca2+-ROS-initiated disruption of the endothelial barrier and triggering intravascular coagulation

Wang

Zhao

et al. 2020

Part Fibre Toxicol

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“…In particular, in the last years, nanosystems based on CyDs have been synthesized with new biological applications, such as potential drug delivery and gene carrier devices …”

Section: Introductionmentioning

confidence: 99%

Exploring the Functionalization of Polymeric Nanoparticles Based on Cyclodextrins for Tumor Cell Targeting

2019

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Some nanotherapeutics based on cyclodextrin polymers are currently undergoing clinical trials. In light of this interest, we synthesized new linear polymers based on β‐cyclodextrins containing targeting units, such as biotin or arginine, to explore the advantage of functionalization for drug delivery. The polymers increased doxorubicin solubility. Furthermore, they slightly enhanced doxorubicin cytotoxicity in A2780 cells. In particular, the polymer containing arginine moieties was the most effective system by increasing doxorubicin cytotoxicity by 50%.

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“…The surfactants will undergo supramolecular assembly by self-aggregating into cylindrical micelles at concentrations higher than the critical micelle concentration, which will lead to the condensation of the silica precursors at the surface. Subsequently, the surfactant template will be removed through calcination or solvent extraction in order to generate the pore network [41,42]. Mesoporous silica materials can be synthesized through various routes, including sol-gel and aerogel methods, precipitation, hydrothermal method, layer-by-layer self-assembly, chemical etching technique, microwave-assisted technique, spray drying, and template-directed method [41,43,44].…”

Section: Mesoporous Silica Synthesis Methodsmentioning

confidence: 99%

“…Therefore, oxo bridges (-O-) between silicon atoms will form and will generate the growth of the silica particles [45,47,48]. The most widely used silicon alkoxide as a precursor for silica, also described in the Stöber method, is tetraethoxysilane or tetraethyl orthosilicate (TEOS) and water and/or ethanol are typically used as solvents [41,49]. Additionally, tetramethoxysilane or tetramethyl orthosilicate (TMOS), tetrapropoxysilane or tetrapropyl orthosilicate (TnPOS), and tetraisopropoxysilane or tetraisopropyl orthosilicate (TiPOS) can be used as silica sources [48].…”

Section: Mesoporous Silica Synthesis Methodsmentioning

confidence: 99%

Mesoporous Silica Platforms with Potential Applications in Release and Adsorption of Active Agents

et al. 2020

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In recent years, researchers focused their attention on mesoporous silica nanoparticles (MSNs) owing to the considerable advancements of the characterization methods, especially electron microscopy methods, which allowed for a clear visualization of the pore structure and the materials encapsulated within the pores, along with the X-ray diffraction (small angles) methods and specific surface area determination by Brunauer–Emmett–Teller (BET) technique. Mesoporous silica gained important consideration in biomedical applications thanks to its tunable pore size, high surface area, surface functionalization possibility, chemical stability, and pore nature. Specifically, the nature of the pores allows for the encapsulation and release of anti-cancer drugs into tumor tissues, which makes MSN ideal candidates as drug delivery carriers in cancer treatment. Moreover, the inner and outer surfaces of the MSN provide a platform for further functionalization approaches that could enhance the adsorption of the drug within the silica network and the selective targeting and controlled release to the desired site. Additionally, stimuli-responsive mesoporous silica systems are being used as mediators in cancer therapy, and through the release of the therapeutic agents hosted inside the pores under the action of specific triggering factors, it can selectively deliver them into tumor tissues. Another important application of the mesoporous silica nanomaterials is related to its ability to extract different hazardous species from aqueous media, some of these agents being antibiotics, pesticides, or anti-tumor agents. The purpose of this paper is to analyze the methods of MSN synthesis and related characteristics, the available surface functionalization strategies, and the most important applications of MSN in adsorption as well as release studies. Owing to the increasing antibiotic resistance, the need for developing materials for antibiotic removal from wastewaters is important and mesoporous materials already proved remarkable performances in environmental applications, including removal or even degradation of hazardous agents such as antibiotics and pesticides.

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Functionalized mesoporous silica nanoparticles and biomedical applications

Cited by 161 publications

References 249 publications

Silica nanomaterials induce organ injuries by Ca2+-ROS-initiated disruption of the endothelial barrier and triggering intravascular coagulation

Silica nanomaterials induce organ injuries by Ca2+-ROS-initiated disruption of the endothelial barrier and triggering intravascular coagulation

Exploring the Functionalization of Polymeric Nanoparticles Based on Cyclodextrins for Tumor Cell Targeting

Mesoporous Silica Platforms with Potential Applications in Release and Adsorption of Active Agents

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