Functionalized nanoceria exhibit improved angiogenic properties

Nethi, Susheel Kumar; Nanda, Himansu Sekhar; Steele, Terry W. J.; Patra, Chitta Ranjan

doi:10.1039/c7tb01957b

Cited by 51 publications

(39 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The application of biocompatible surface modifying moiety, MEEETES inhibits aggregation and enables dispersion in media. Their results comparing the zeta potential of the nanoparticles at day 0 and at day 180 showed that the zeta potential changed from between −11 and −12 mV at day 0 to between −14 and −13 mV on day 180 [71]. These insignificant changes over a period of 180 days suggests that the zeta potential of nanoparticle can be stabilized over time by the application of stabilizing/doping agents.…”

Section: Precipitation Methodsmentioning

confidence: 99%

Synthesis of Cerium Oxide Nanoparticles Using Various Methods: Implications for Biomedical Applications

et al. 2020

View full text Add to dashboard Cite

Cerium oxide nanoparticles have been used in a number of non-medical products over the years. The therapeutic application of these nanoparticles has mainly been due to their oxidative stress ameliorating abilities. Their enzyme-mimetic catalytic ability to change between the Ce3+ and Ce4+ species makes them ideal for a role as free-radical scavengers for systemic diseases as well as neurodegenerative diseases. In this review, we look at various methods of synthesis (including the use of stabilizing/capping agents and precursors), and how the synthesis method affects the physicochemical properties, their behavior in biological environments, their catalytic abilities as well as their reported toxicity.

show abstract

Section: Precipitation Methodsmentioning

confidence: 99%

Synthesis of Cerium Oxide Nanoparticles Using Various Methods: Implications for Biomedical Applications

et al. 2020

View full text Add to dashboard Cite

show abstract

“…These nanomaterials activate kinases such as Akt, extracellular regulated protein kinases (ERK) 1/2, mitogen-activated protein kinase (MAPK) p38 [115] and eNOS, which are ROS-dependent, even though the production of ROS is always associated with cytotoxicity. Nethi et al designed functionalized nanoconjugates of (6-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-hexyl) triethoxysilane and samarium doped cerium oxide nanoparticles (MTS-SmCeO 2 ) to promote endothelial cell viability and blood vessel formation in a chick embryo model by decreasing high levels of ROS in EA.hy926 cells to optimal levels and enhancing the activation of the p38 MAPK/HIF-1α signalling pathway [116]. Cerium oxide nanoparticles also utilize oxygen vacancies on the surface of the lattice to scavenge free radicals and reduce the damage caused by oxidative stress, thus stabilizing HIF-1α and leading to angiogenesis [42,117].…”

Section: Activation Of Redox Signallingmentioning

confidence: 99%

Insights into the angiogenic effects of nanomaterials: mechanisms involved and potential applications

Liu

Zhang

et al. 2020

J Nanobiotechnol

View full text Add to dashboard Cite

The vascular system, which transports oxygen and nutrients, plays an important role in wound healing, cardiovascular disease treatment and bone tissue engineering. Angiogenesis is a complex and delicate regulatory process. Vascular cells, the extracellular matrix (ECM) and angiogenic factors are indispensable in the promotion of lumen formation and vascular maturation to support blood flow. However, the addition of growth factors or proteins involved in proangiogenic effects is not effective for regulating angiogenesis in different microenvironments. The construction of biomaterial scaffolds to achieve optimal growth conditions and earlier vascularization is undoubtedly one of the most important considerations and major challenges among engineering strategies. Nanomaterials have attracted much attention in biomedical applications due to their structure and unique photoelectric and catalytic properties. Nanomaterials not only serve as carriers that effectively deliver factors such as angiogenesis-related proteins and mRNA but also simulate the nano-topological structure of the primary ECM of blood vessels and stimulate the gene expression of angiogenic effects facilitating angiogenesis. Therefore, the introduction of nanomaterials to promote angiogenesis is a great helpful to the success of tissue regeneration and some ischaemic diseases. This review focuses on the angiogenic effects of nanoscaffolds in different types of tissue regeneration and discusses the influencing factors as well as possible related mechanisms of nanomaterials in endothelial neovascularization. It contributes novel insights into the design and development of novel nanomaterials for vascularization and therapeutic applications.

show abstract

“…Further research on the relevance of the Ce(III)/Ce(IV) ratio was conducted by incorporating trivalent metal ions [84]. It was hypothesized that samarium (III) doping of CO-NPs (smCO-NPs) would allow tuning of the Ce(III)/Ce(IV) ratio in the NPs, thus enhancing the angiogenic potential of the NPs.…”

Section: Therapeutic Angiogenesismentioning

confidence: 99%

Cerium- and Iron-Oxide-Based Nanozymes in Tissue Engineering and Regenerative Medicine

Jansman

Hosta‐Rigau

2019

Catalysts

View full text Add to dashboard Cite

Nanoparticulate materials displaying enzyme-like properties, so-called nanozymes, are explored as substitutes for natural enzymes in several industrial, energy-related, and biomedical applications. Outstanding high stability, enhanced catalytic activities, low cost, and availability at industrial scale are some of the fascinating features of nanozymes. Furthermore, nanozymes can also be equipped with the unique attributes of nanomaterials such as magnetic or optical properties. Due to the impressive development of nanozymes during the last decade, their potential in the context of tissue engineering and regenerative medicine also started to be explored. To highlight the progress, in this review, we discuss the two most representative nanozymes, namely, cerium- and iron-oxide nanomaterials, since they are the most widely studied. Special focus is placed on their applications ranging from cardioprotection to therapeutic angiogenesis, bone tissue engineering, and wound healing. Finally, current challenges and future directions are discussed.

show abstract

Functionalized nanoceria exhibit improved angiogenic properties

Abstract: Overall schematic representation of the synthesis, characterization and proangiogenic activity of functionalized nanoceria.

Cited by 51 publications

References 59 publications

Synthesis of Cerium Oxide Nanoparticles Using Various Methods: Implications for Biomedical Applications

Synthesis of Cerium Oxide Nanoparticles Using Various Methods: Implications for Biomedical Applications

Insights into the angiogenic effects of nanomaterials: mechanisms involved and potential applications

Cerium- and Iron-Oxide-Based Nanozymes in Tissue Engineering and Regenerative Medicine

Contact Info

Product

Resources

About