Functionalized polymers for tissue engineering and regenerative medicines

Tariverdian, Tara; Navaei, Tina; Milan, Peiman Brouki; Samadikuchaksaraei, Alí; Mozafari, Masoud

doi:10.1016/b978-0-12-816349-8.00016-3

Cited by 20 publications

(8 citation statements)

References 143 publications

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“…Alginate, or alginic acid, is a heteropolysaccharide derived from brown algae [ 30 ]. It has a unique ability to form gels through ionic crosslinking when exposed to bipolar ions such as calcium, barium, zinc, and strontium [ 31 , 32 , 33 , 34 ].…”

Section: Biological Bioinksmentioning

confidence: 99%

Bioprinting Au Natural: The Biologics of Bioinks

2021

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The development of appropriate bioinks is a complex task, dependent on the mechanical and biochemical requirements of the final construct and the type of printer used for fabrication. The two most common tissue printers are micro-extrusion and digital light projection printers. Here we briefly discuss the required characteristics of a bioink for each of these printing processes. However, physical printing is only a short window in the lifespan of a printed construct—the system must support and facilitate cellular development after it is printed. To that end, we provide a broad overview of some of the biological molecules currently used as bioinks. Each molecule has advantages for specific tissues/cells, and potential disadvantages are discussed, along with examples of their current use in the field. Notably, it is stressed that active researchers are trending towards the use of composite bioinks. Utilizing the strengths from multiple materials is highlighted as a key component of bioink development.

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Section: Biological Bioinksmentioning

confidence: 99%

Bioprinting Au Natural: The Biologics of Bioinks

2021

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“…Alginate, the term generally used for alginic acid salts and derivatives, but also for alginic acid itself, is a natural linear polysaccharide consisting of β-(1,4)-linked D-mannuronic acid and α-(1,4)-linked L-guluronic acid units [72][73][74][75][76]. Consequently, the polymeric backbone consists of homogenous sequences of mannuronic acid (M) or guluronic acid (G) blocks, and alternating sequences (MG) [72,77,78].…”

Section: Marine Polysaccharides For Neuroprotectionmentioning

confidence: 99%

“…Alginate is extracted from brown algae, where it exhibits structural functions as a cell wall component, comprising about 30% dry weight. Most common sources of alginate are Laminaria hyperborea, Laminaria digitata, Macrocystis pyrifera, Ascophyllum nodosum, and Laminaria japonica [72][73][74][75]77,79,80]. Alginate is usually extracted through the dissolution of seaweed biomass with a basic solution, precipitation in calcium chloride, filtration, purification, and drying steps [75,80].…”

Section: Marine Polysaccharides For Neuroprotectionmentioning

confidence: 99%

Marine Biocompounds for Neuroprotection—A Review

2020

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While terrestrial organisms are the primary source of natural products, recent years have witnessed a considerable shift towards marine-sourced biocompounds. They have achieved a great scientific interest due to the plethora of compounds with structural and chemical properties generally not found in terrestrial products, exhibiting significant bioactivity ten times higher than terrestrial-sourced molecules. In addition to the antioxidant, anti-thrombotic, anti-coagulant, anti-inflammatory, anti-proliferative, anti-hypertensive, anti-diabetic, and cardio-protection properties, marine-sourced biocompounds have been investigated for their neuroprotective potential. Thus, this review aims to describe the recent findings regarding the neuroprotective effects of the significant marine-sourced biocompounds.

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“…7 Bio-functionalized dressings not only decrease the time needed for wound closure, but also modulate the formation of scar tissue by regulating the deposition of ECM. 8,9 ECM can be extracted and used from various cultured cells, and tissues, including human placenta tissue, which is normally discarded after birth. 10,11 The extracted ECM could be used as a biological component of the dressing to improve the healing.…”

Section: Introductionmentioning

confidence: 99%

“…Several studies have reported that application of dressings containing ECM components, that is, bio‐functionalized dressings, can improve the process of wound healing 7 . Bio‐functionalized dressings not only decrease the time needed for wound closure, but also modulate the formation of scar tissue by regulating the deposition of ECM 8,9 …”

Section: Introductionmentioning

confidence: 99%

Fabrication and characterization of a hydrocolloid wound dressing functionalized with human placental derived extracellular matrix for management of skin wounds: An animal study

Jafari,

Gholipourmalekabadi,

Alizadeh

et al. 2023

Artificial Organs

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BackgroundFunctionalization of wound dressing is one of the main approaches for promoting wound healing in skin wound management. In this study, our aim is to fabricate a bio‐functionalized hydrocolloid wound dressing.MethodsThe extracellular matrix (ECM) was extracted from human placental tissue. A hydrocolloid film was fabricated using Na‐CMC, pectin, gelatin, styrene‐isoprene‐styrene adhesive, glycerol, and 0.5%–2.5% powdered ECM. A polyurethane film and a release liner were used in the hydrocolloid/ECM films. The mechanical, adhesion, swelling rate, and integrity of the films were investigated. Cell proliferation, adhesion, and migration assays, as well as, SEM and FTIR spectroscopy were also conducted. Macroscopic and microscopic evaluations of wound healing process and formation of blood vessels were conducted in mouse animal models.ResultsWe successfully fabricated a three‐layered ECM‐functionalized hydrocolloid dressing with a water vapor transmission rate of 371 g/m2/day and an adhesion peel strength of 176 KPa. Cellular adhesion, proliferation and migration were promoted by ECM. In the animal tests, ECM‐functionalized hydrocolloids significantly improved wound closure and re‐epithelialization at days 14 and 21. Also, ECM‐functionalized hydrocolloids promoted the formation of hair follicles.ConclusionsOur findings suggest that ECM could enhance the wound healing properties of hydrocolloid wound dressings. This wound dressing could be considered for application in hard‐to‐heal acute wounds.

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Functionalized polymers for tissue engineering and regenerative medicines

Cited by 20 publications

References 143 publications

Bioprinting Au Natural: The Biologics of Bioinks

Bioprinting Au Natural: The Biologics of Bioinks

Marine Biocompounds for Neuroprotection—A Review

Fabrication and characterization of a hydrocolloid wound dressing functionalized with human placental derived extracellular matrix for management of skin wounds: An animal study

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