Functionalized ZnO-Based Nanocomposites for Diverse Biological Applications: Current Trends and Future Perspectives

Abstract

The wide array of structures and characteristics found in ZnO-based nanostructures offers them a versatile range of uses. Over the past decade, significant attention has been drawn to the possible applications of these materials in the biomedical field, owing to their distinctive electronic, optical, catalytic, and antimicrobial attributes, alongside their exceptional biocompatibility and surface chemistry. With environmental degradation and an aging population contributing to escalating healthcare needs and costs, particularly in developing nations, there’s a growing demand for more effective and affordable biomedical devices with innovative functionalities. This review delves into particular essential facets of different synthetic approaches (chemical and green) that contribute to the production of effective multifunctional nano-ZnO particles for biomedical applications. Outlining the conjugation of ZnO nanoparticles highlights the enhancement of biomedical capacity while lowering toxicity. Additionally, recent progress in the study of ZnO-based nano-biomaterials tailored for biomedical purposes is explored, including biosensing, bioimaging, tissue regeneration, drug delivery, as well as vaccines and immunotherapy. The final section focuses on nano-ZnO particles’ toxicity mechanism with special emphasis to their neurotoxic potential, as well as the primary toxicity pathways, providing an overall review of the up-to-date development and future perspectives of nano-ZnO particles in the biomedicine field.

Advancements in the Synthesis and Functionalization of Zinc Oxide-Based Nanomaterials for Enhanced Oral Cancer Therapy

“…In the context of oral cancer treatment, ZnO-based nanomaterials have garnered significant interest due to their inherent anticancer properties and biocompatibility. Numerous synthesis approaches have been established to produce ZnO nanoparticles with exact sizes, shapes, and surface properties [ 14 ]. This section delves into some of the most generally used synthesis methods for ZnO-based nanomaterials ( Figure 1 ).…”

“…The development of multifunctional ZnO-based nanoplatforms capable of simultaneous imaging, drug delivery, and therapeutic monitoring holds promise for personalized and precision cancer therapy. The integration of imaging modalities, such as fluorescence, MRI or PET, enables the real-time visualization of tumor growth, metastasis, and treatment response, facilitating early diagnosis and treatment optimization [ 14 ]. Combining ZnO-based nanotherapeutics with conventional chemotherapy, radiotherapy, or immunotherapy offers synergistic effects and enhanced therapeutic outcomes in oral cancer treatment.…”