Functionalizing Sgc8‐Paclitaxel Conjugates with F‐Base Modifications: Targeted Drug Delivery with Optimized Cardiac Safety
Yue Ma,
Xianying Liao,
Guiping Lu
et al.
Abstract:Recent advancements in cancer treatment have improved patient prognoses, but chemotherapy‐induced cardiotoxicity remains a prevalent concern. This study explores the potential of F‐base‐modified aptamers for targeted drug delivery, focusing on their impact on cardiotoxicity. From the phosphoramidite, F‐base functionalized Sgc8‐F23 was prepared in an automated and programmable way, which was further reacted with Paclitaxel (PTX) to give the F‐base modified aptamer Sgc8‐paclitaxel conjugates (Sgc8‐F23‐PTX) effic… Show more
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