Functionally aberrant dendritic cell subsets and expression of DC-SIGN differentiate acute from chronic HBV infection

Sukriti, Sukriti; Trehanpati, Nirupma; Kumar, Manoj; Pande, Chandana; Hissar, Syed; Sarin, Shiv Kumar

doi:10.1007/s12072-016-9763-0

Cited by 6 publications

(7 citation statements)

References 20 publications

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“…However, despite efficient internalization, HBV does not trigger IFN‐α, IL‐6, and TNF‐α secretion by pDCs . HBV not only does not activate pDCs, but also actively inhibit their function . Cytokine production of pDCs differs significantly between CHB patients and healthy individuals.…”

Section: Pdcs and Hbvmentioning

confidence: 97%

Immune function of plasmacytoid dendritic cells, natural killer cells, and their crosstalk in HBV infection

Golsaz‐Shirazi

Amiri

Shokri

2018

Reviews in Medical Virology

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Chronic hepatitis B virus infection is a major health problem, with over 245 million chronic carriers worldwide. This persistent infection is thought to be associated with inefficient innate and adaptive immune responses. Natural killer cells (NK cells) and plasmacytoid dendritic cells (pDCs) are the major innate immune cells which respond to viral infection at the early phase and are considered major components of the antiviral immune response. In this review, we summarize recent findings regarding the role of NK cells, pDCs, and their cross-talk in HBV infection and its chronicity. Although the data regarding the biological function of pDCs and NK cells in HBV infection is still controversial, many studies show that in chronic HBV infection, the cytotoxicity of NK cells is retained, while their capacity to secrete cytokines is strongly impaired. In addition, interferon-α production by pDCs is impaired during chronic HBV infection, and the virus interferes with pDC-NK cell interaction.

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Section: Pdcs and Hbvmentioning

confidence: 97%

Immune function of plasmacytoid dendritic cells, natural killer cells, and their crosstalk in HBV infection

Golsaz‐Shirazi

Amiri

Shokri

2018

Reviews in Medical Virology

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“…Similar data indicate reduced expression of dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin and reduced secretion of IFNa and IFNk. (29,30) However, in vitro human DC2s secreted IFNk in response to HCV exposure, and this in turn provoked the secretion of IFNa from pDCs, suggesting an innate immune activation cascade. (31) Although there is little information about DCs within hepatitis virus-infected human liver, we know the proportion of DC1s and DC2s are changed.…”

Section: Dendritic Cells In Viral Hepatitismentioning

confidence: 99%

Dendritic cells in hepatitis and liver transplantation

Soysa

Wu²

2017

Liver Transpl

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Dendritic cells (DCs) play a key role in innate immune responses and are also the most effective cells for the activation of T cell immunity. They acquire antigen and process it; then they display it on the cell surface bound in a noncovalent complex with human leukocyte antigen molecules of class I (human leukocyte antigens A, B, and C) and class II (human leukocyte antigen DR). These cells are subdivided into 3 main subsets: 2 called myeloid dendritic cells (mDC) or classical DCs of types 1 and 2, and 1 called plasmacytoid dendritic cells (pDCs). The mDCs process and present antigen while the pDCs also strongly respond to viral signals by secreting type 1 interferon. In the liver, all of these subsets are present. However, their relative abundance is different from the peripheral blood, and it is further modified by liver disease. It appears that in relation to T cell tolerance, both mDCs and pDCs are influenced by the liver milieu and promote T cell inactivation. However, in antiviral responses and in ischemia/reperfusion injury, where innate immune functions are more important, mDCs and pDCs have distinct roles. Liver Transplantation 23 1433-1439 2017 AASLD.

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“…Other studies reported that the maturation of pDCs was impaired after stimulation with TLR agonists in patients with chronic HBV infection. In addition, pDCs not only produced decreased IFN‐alpha (IFN‐α), TNF‐α, and IFN‐lambda1 (IFN‐λ1) but also expressed perturbed C‐type lectin receptors which play a crucial role in orchestrating with DCs to respond to pathogens 37–39 . Dysfunction of DCs caused by HBV is a potential mechanism for chronic HBV infection and restoring DC functions may offer a new option for curing persistent HBV infection (Figure 2).…”

Section: Introductionmentioning

confidence: 99%

Dendritic cell‐based immunotherapy: A potential therapeutic option for chronic Hepatitis B virus infection

2023

Clinical and Translational Dis

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Dendritic cells (DCs) play a crucial role in initiating the adaptive immune response that could determine the outcome of Hepatitis B virus infection. The efficacy of DC-based immunotherapy may be improved via several strategies including treatment of interleukin-12, pDC-derived interferon (IFN)-α, monophosphoryl lipid A and IFN-γ, uric acid as well as blockade of B7 homolog 1. Besides, DCs with an engineered expression of HBV S-ecdCD40L, or pulsed with M1:HBcAg conjugates or transfection of recombinant plasmid pEGFP-N1-C (472-507)-ecdCD40L also showed improved efficacy.

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Functionally aberrant dendritic cell subsets and expression of DC-SIGN differentiate acute from chronic HBV infection

Abstract: The initial events of immune activation might be responsible for modulating immune response. These novel observations would pave the way for the development of antiviral strategies for chronic HBV infection.

Cited by 6 publications

References 20 publications

Immune function of plasmacytoid dendritic cells, natural killer cells, and their crosstalk in HBV infection

Immune function of plasmacytoid dendritic cells, natural killer cells, and their crosstalk in HBV infection

Dendritic cells in hepatitis and liver transplantation

Dendritic cell‐based immunotherapy: A potential therapeutic option for chronic Hepatitis B virus infection

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