Functionally distinct subsets of human NK cells and monocyte/DC-like cells identified by coexpression of CD56, CD7, and CD4

Lineage relationships of human interleukin-22–producing CD56+ RORγt+ innate lymphoid cells and conventional natural killer cells

“…51 Whether or not this small cell fraction expresses ROR-gt and could belong to the ILC22 lineage is plausible but has not been formally addressed. However, given the expression of SLT adhesion and homing receptors on ILC22 cells, they would not be expected to be abundant in the peripheral circulation.…”

Human CD56bright NK Cells: An Update

“…This adds to the growing insight into a greater plasticity of hematopoiesis than previously thought. Nevertheless, it is very important to confirm that the CD3 2 CD56 + cells observed are indeed NK cells, because myeloid cells, such as monocyte/dendritic cell-like cells, can also express CD56 but are CD7 2 and lack classical NK cellassociated markers (16). The topic is even more complex because epigenetic factors also play a role, but this applies more to a diversification of adaptive memory-like CD56 dim subsets functionally different from the so-called canonical CD56 dim NK cells (17,18).…”

Connecting the dots: monocyte/DC and NK subsets in human peripheral blood

“…1 Whereas this study delivers a valuable improvement in the definition of peripheral blood NK cells, it leaves unresolved the question of which monocyte/ dendritic cells were found to express CD56. Approaching this problem from the other direction, we characterized the CD56 expression of monocytes and blood DC subsets from healthy volunteers.…”