Functionally graded materials (FGMs) attract considerable interest in materials science and industry, since their composition or morphology gradually changes along their length, width, or height, which provides new approach for the development of multifunctional materials. In this paper, we studied the fabrication of a gradient microstructure in alumina (Al2O3) by spark plasma sintering (SPS). During the SPS process, the applied asymmetric graphite tool configuration causes a large temperature gradient, which results in a gradually changing morphology in Al2O3 ceramics. The local temperatures were quantitatively measured through extra thermocouples during SPS processes with various asymmetric configurations. In the most asymmetric configuration, a maximum vertical temperature difference of 225 °C was detected within the sample treated at a sintering temperature of 1300 °C and a pressure of 25 MPa applied 200 °C·min−1 heating rate. The microstructure investigations demonstrated the morphology gradient in the ceramic: one part of the Al2O3 exhibited fine, nanostructured morphology with large open and permeable pores, whereas the other part was solid without pores. Our investigations show that a gradient Al2O3 ceramic can be produced with a single-step SPS process, which offers new directions in FGMs research. With an asymmetric sintering configuration and the sintering conditions, the structure of the ceramic, such as porosity, can be designed according to the requirements of the application area.