1998
DOI: 10.1016/s0092-8674(00)81770-5
|View full text |Cite
|
Sign up to set email alerts
|

Functionally Related Motor Neuron Pool and Muscle Sensory Afferent Subtypes Defined by Coordinate ETS Gene Expression

Abstract: Motor function depends on the formation of selective connections between sensory and motor neurons and their muscle targets. The molecular basis of the specificity inherent in this sensory-motor circuit remains unclear. We show that motor neuron pools and subsets of muscle sensory afferents can be defined by the expression of ETS genes, notably PEA3 and ER81. There is a matching in PEA3 and ER81 expression by functionally interconnected sensory and motor neurons. ETS gene expression by motor and sensory neuron… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

10
264
1
1

Year Published

1999
1999
2015
2015

Publication Types

Select...
6
1

Relationship

0
7

Authors

Journals

citations
Cited by 313 publications
(276 citation statements)
references
References 56 publications
10
264
1
1
Order By: Relevance
“…In the dorsal root ganglion (DRG), MDGA1 was not expressed by the dorsal DRG neurons ( Figure 2G, K), which are TrkA-positive (Lin et al, 1998), suggesting that the majority of the DRG's nociceptive neurons are MDGA1-negative. Of the spinal motor neurons, MDGA1 was not expressed by cervical-and thoracic-level MMC (medial motor column) motor neurons (Supplemental figure 2).…”
Section: Fy29/mdga1 Is a Gpi-anchored Extracellular Protein Selectivementioning
confidence: 99%
“…In the dorsal root ganglion (DRG), MDGA1 was not expressed by the dorsal DRG neurons ( Figure 2G, K), which are TrkA-positive (Lin et al, 1998), suggesting that the majority of the DRG's nociceptive neurons are MDGA1-negative. Of the spinal motor neurons, MDGA1 was not expressed by cervical-and thoracic-level MMC (medial motor column) motor neurons (Supplemental figure 2).…”
Section: Fy29/mdga1 Is a Gpi-anchored Extracellular Protein Selectivementioning
confidence: 99%
“…Although all these motor neurons originate from a common precursor population in ventral neural tube and share many features in common at maturity, each motor pool has unique distinguishing characteristics. Neurons within an individual motor pool reside in a characteristic position in the LMC (Landmesser, 1978), exhibit a distinctive pattern of spontaneous electrical activity (Milner and Landmesser, 1999), express a unique set of LIM homeodomain and ETS transcription factors and cadherins (Tsuchida et al, 1994;Lin et al, 1998;Price et al, 2002), innervate a single target muscle, and receive monosynaptic input from sensory neurons supplying the same muscle (reviewed in Chen et al, 2003). These distinguishing properties of motor pools arise through the sequential activation of different transcriptional networks (reviewed in Shirasaki and Pfaff, 2002).…”
Section: Introductionmentioning
confidence: 99%
“…Many important aspects of the unique motor pool identities are specified early in development prior to target innervation, and, therefore, are governed by transcriptional programs that are independent of target-derived signals (reviewed in Shirasaki and Pfaff, 2002). Other characteristics, for example expression of the ETS transcription factors ER81 and PEA3, ap-pear somewhat later in development after axons enter the limb, being triggered and refined by interactions with limb-derived signals (Lin et al, 1998;Price et al, 2002;Wang and Scott, 2004). The precise temporal activation of these transcriptional programs is essential for the normal maturation of both motor (reviewed in Shirasaki and Pfaff, 2002) and sensory neurons (Hippenmeyer et al, 2005).…”
Section: Introductionmentioning
confidence: 99%
See 2 more Smart Citations