Functionally Tailored Metal–Organic Framework Coatings for Mediating Ti Implant Osseointegration

Abstract

Owing to their mechanical resilience and non‐toxicity, titanium implants are widely applied as the major treatment modality for the clinical intervention against bone fractures. However, the intrinsic bioinertness of Ti and its alloys often impedes the effective osseointegration of the implants, leading to severe adverse complications including implant loosening, detachment, and secondary bone damage. Consequently, new Ti implant engineering strategies are urgently needed to improve their osseointegration after implantation. Remarkably, metalorganic frameworks (MOFs) are a class of novel synthetic material consisting of coordinated metal species and organic ligands, which have demonstrated a plethora of favorable properties for modulating the interfacial properties of Ti implants. This review comprehensively summarizes the recent progress in the development of MOF‐coated Ti implants and highlights their potential utility for modulating the bio‐implant interface to improve implant osseointegration, of which the discussions are outlined according to their physical traits, chemical composition, and drug delivery capacity. A perspective is also provided in this review regarding the current limitations and future opportunities of MOF‐coated Ti implants for orthopedic applications. The insights in this review may facilitate the rational design of more advanced Ti implants with enhanced therapeutic performance and safety.

Advances in biomaterials for oral-maxillofacial bone regeneration: spotlight on periodontal and alveolar bone strategies

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Shear Flow-Assembled Janus Membrane with Bifunctional Osteogenic and Antibacterial Effects for Guided Bone Regeneration

“…Bone repair, a complex multifactorial process, is crucial for skeletal system health. − Guided bone regeneration (GBR) membranes that reside at the interface between the bone and surrounding soft tissues have attracted increasing attention in bone repair and regeneration. , GBR membranes can serve as a barrier to prevent the invasion of soft tissue cells into the bone defect while promoting osteogenic differentiation. − Recent research efforts about GBR membranes have focused on the enhancement of osteogenic differentiation and antibacterial effects. For instance, Bottino and collaborators doped β-tricalcium phosphate to fabricate a GBR membrane with a uniform porous network, which increased cell attachment, proliferation, mineralization, and osteogenic gene expression .…”

Fabricating a PDA-NOate@CuS coated NIR-activatable titanium implant to realize simultaneous antiinfection and osseointegration

“…Titanium metal has been widely used as an implant substrate in clinical practice due to its high mechanical strength and biocompatibility, 1 but it is unable to prevent the growth and colonization of bacteria on its surface. Bacteria that colonize the titanium surface can cause implant-associated infections (IAIs), 2,3 which often require a second surgical debridement, which can be extremely painful for the patient.…”