Functioning of Lycopene in Mammalian System: A Review

Sharma, Namita; Goswami, Umesh

doi:10.1007/s12595-011-0005-0

Cited by 9 publications

(9 citation statements)

References 56 publications

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“…The iron-supplemented liver presented morphological changes associated with proliferation and autophagy but no apoptosis, damages prevented by lycopene pre-treatment. Dietary intakes of tomatoes and tomato products containing lycopene have been shown to be associated with decreased risk of chronic diseases such as cancer and cardiovascular diseases in several recent studies (Huang and Hu, 2011;Sharma and Goswami, 2011). In this study, we noted the increase in food ingestion observed in rats with lycopene supplementation.…”

Section: Ultrastructural Alterations and Autophagy In Liversupporting

confidence: 59%

“…In these last decades, there was growing interest in the association of specifi c components of human nutrition and oxidative stress (Morihara et al, 2006;Dairam et al, 2008). Lycopene, a carotenoid compound, occurring naturally in tomato and other fruits like papaya, pink guava and watermelon has been shown to neutralize free radicals, especially those derived from oxygen, thereby conferring protection against cancer of the prostate, breast, lung, bladder, cervix and skin, atherosclerosis and associated coronary artery disease (Sharma and Goswami, 2011). Dietary intakes of cooked tomatoes and their by-products account for 90% of the lycopene in the average Southern and North American diet (Bose and Agrawal, 2007;Garciaalonso et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

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Protective effects of lycopene on oxidative stress, proliferation and autophagy in iron supplementation rats

et al. 2013

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Lycopene is common in diet and known for its antioxidant activities. However, the impact of lycopene on iron metabolism is poorly investigated. In this study, we hypothesize that lycopene can prevent iron-mediated oxidative stress, proliferation and autophagy in liver and use a rat model of nutritional iron supplementation to confi rm its intervention in these defence mechanisms. We found that iron supplementation induced cell proliferation predominantly in non parenchymal cells compared with hepatocytes, but not apoptosis. In addition, iron was accumulated within the hepatic lysosomes where it triggered autophagy as evidenced by the formation of autophagic vesicles detected by LC3-B staining. Iron supplementation also induced morphologic alterations of the mitochondrial membranes probably due to increased lipid peroxidation as indicated by elevated iron and malondialdehyde concentrations in serum and tissues. Lycopene reduced iron-catalyzed lipid peroxidation by decreasing the malondialdehyde level in the liver and colon and enhancing the total superoxide dismutase activities in serum and tissues. The result suggest that lycopene prevents iron-induced oxidative stress, proliferation and autophagy at both biochemical and histological levels due to its potent free radical scavenging and antioxidant properties.

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Section: Ultrastructural Alterations and Autophagy In Liversupporting

confidence: 59%

Section: Introductionmentioning

confidence: 99%

Protective effects of lycopene on oxidative stress, proliferation and autophagy in iron supplementation rats

et al. 2013

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“…This response can include stimulating DNA repair pathways, as well as antioxidative agents. In addition to a putative role in regulating membrane fluidity (discussed above), heightened synthesis of the carotenoid lycopene in P. halocryophilus under cold conditions would also be important in the oxidative response, as it is known to neutralize free oxygen radicals (Sharma and Goswami, 2011). As a carotenoid, it would also mitigate potential oxidative stress from UV radiation.…”

Section: Oxidative and Carbonyl Stressmentioning

confidence: 99%

Mechanisms of subzero growth in the cryophile Planococcus halocryophilus determined through proteomic analysis

Raymond-Bouchard

Chourey

Altshuler

et al. 2017

Environmental Microbiology

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The eurypsychrophilic bacterium Planococcus halocryophilus is capable of growth down to -15°C, making it ideal for studying adaptations to subzero growth. To increase our understanding of the mechanisms and pathways important for subzero growth, we performed proteomics on P. halocryophilus grown at 23°C, 23°C with 12% w/v NaCl and -10°C with 12% w/v NaCl. Many proteins with increased abundances at -10°C versus 23°C also increased at 23C-salt versus 23°C, indicating a closely tied relationship between salt and cold stress adaptation. Processes which displayed the largest changes in protein abundance were peptidoglycan and fatty acid (FA) synthesis, translation processes, methylglyoxal metabolism, DNA repair and recombination, and protein and nucleotide turnover. We identified intriguing targets for further research at -10°C, including PlsX and KASII (FA metabolism), DD-transpeptidase and MurB (peptidoglycan synthesis), glyoxalase family proteins (reactive electrophile response) and ribosome modifying enzymes (translation turnover). PemK/MazF may have a crucial role in translational reprogramming under cold conditions. At -10°C P. halocryophilus induces stress responses, uses resources efficiently, and carefully controls its growth and metabolism to maximize subzero survival. The present study identifies several mechanisms involved in subzero growth and enhances our understanding of cold adaptation.

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“…Lycopene (Ly), the most common type of carotenoid in dietary intake, has been shown to confer protective effects against ageing, tissue damage, certain types of cancer, atherosclerosis and associated coronary artery disease (10). Possible mechanisms of Ly-mediated effects are via antioxidant activity, increases in gap-junctional intercellular communication, cell growth control, the activation of the mevalonic acid pathway, suppressing the expression of the oncogene ras and the modulation of immune responses (11)(12)(13)(14).…”

Section: Introductionmentioning

confidence: 99%

Lycopene protects against apoptosis in hypoxia/reoxygenation-induced H9C2 myocardioblast cells through increased autophagy

Chen

Sun

et al. 2014

Molecular Medicine Reports

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Lycopene (Ly), the most common type of antioxidant in the majority of diet types, provides tolerance to ischemia/reperfusion injury. However, the underlying mechanism of the protective effects observed following Ly administration remains poorly investigated. The aim of the current study was to investigate whether Ly prevents damage to hypoxia/reoxygenation (HR)‑induced H9C2 myocardioblasts in an autophagy‑dependent manner. The levels of autophagic markers were detected using western blotting, the level of apoptosis was detected using western blotting and flow cytometry. The activation of autophagy was impaired via knockdown of the expression of 'microtubule‑associated protein 1‑light chain 3β (MAP1LC3B)' and 'Beclin 1'. After 16 h hypoxia, followed by 2 h reoxygenation, the expression levels of the microtubule‑associated protein 1A/1B‑light chain 3 (LC3) and Βeclin 1 autophagic biomarkers, and cell viability were reduced, whereas the percentage of apoptotic cells, and the expression levels of the Bax/B‑cell lymphoma 2 (Bcl‑2) and active caspase‑3 apoptotic biomarkers were increased. Pre‑incubation of the cells with different Ly concentrations reversed the HR‑induced inhibition of autophagy and cell viability, and the HR‑induced elevation in apoptotic levels. The induction of autophagy was accompanied by reduced apoptosis, and decreased expression levels of Bax/Bcl‑2 and active caspase‑3. In addition, the impairment of autophagy by silencing the expression of MAP1LC3B and Beclin 1 accelerated HR‑induced H9C2 cell apoptosis and the Ly‑mediated protective effects disappeared. Furthermore, Bax/Bcl‑2 and active caspase‑3 expression levels were increased. Moreover, Ly‑induced autophagy was associated with increased adenosine monophosphate kinase (AMPK) phosphorylation. Suppressed AMPK phosphorylation using compound C terminates Ly‑mediated cytoprotective effects. Ly treatment improves cell viability and reduces apoptosis as a result of the activation of the adaptive autophagic response on HR‑induced H9C2 myocardioblasts. AMPK phosphorylation may be involved in the progression.

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Functioning of Lycopene in Mammalian System: A Review

Cited by 9 publications

References 56 publications

Protective effects of lycopene on oxidative stress, proliferation and autophagy in iron supplementation rats

Protective effects of lycopene on oxidative stress, proliferation and autophagy in iron supplementation rats

Mechanisms of subzero growth in the cryophile Planococcus halocryophilus determined through proteomic analysis

Lycopene protects against apoptosis in hypoxia/reoxygenation-induced H9C2 myocardioblast cells through increased autophagy

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