Functions and mechanisms of circular RNAs in cancer radiotherapy and chemotherapy resistance

Cui, Chaochu; Yang, Jianbo; Li, Xiao; Liu, Dongling; Fu, Liwu; Wang, Xianwei

doi:10.1186/s12943-020-01180-y

Cited by 147 publications

(113 citation statements)

References 164 publications

(232 reference statements)

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“…In addition, although most circRNAs mediate drug resistance by acting as sponges, other molecular mechanisms have also been reported, such as maintaining the stability of downstream miRNAs [166]. Common mechanisms underlying drug resistance include DNA repair, abnormal activation of signaling pathways, cancer stemness and the EMT [218]. A primary action of chemotherapy is to mediate DNA damage in cells, which in turn induces cancer cell death.…”

Section: Future Potentialmentioning

confidence: 99%

CircRNAs in anticancer drug resistance: recent advances and future potential

Wang

Jiang

et al. 2020

Mol Cancer

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CircRNAs are a novel class of RNA molecules with a unique closed continuous loop structure. CircRNAs are abundant in eukaryotic cells, have unique stability and tissue specificity, and can play a biological regulatory role at various levels, such as transcriptional and posttranscriptional levels. Numerous studies have indicated that circRNAs serve a crucial purpose in cancer biology. CircRNAs regulate tumor behavioral phenotypes such as proliferation and migration through various molecular mechanisms, such as miRNA sponging, transcriptional regulation, and protein interaction. Recently, several reports have demonstrated that they are also deeply involved in resistance to anticancer drugs, from traditional chemotherapeutic drugs to targeted and immunotherapeutic drugs. This review is the first to summarize the latest research on circRNAs in anticancer drug resistance based on drug classification and to discuss their potential clinical applications.

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Section: Future Potentialmentioning

confidence: 99%

CircRNAs in anticancer drug resistance: recent advances and future potential

Wang

Jiang

et al. 2020

Mol Cancer

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“…Chemoresistance is one of the main causes for therapeutic failure in cancers. Dysregulated autophagy [ 8 , 107 , 108 ], lncRNAs [ 33 , 109 , 110 , 111 ], and circRNAs [ 107 , 112 , 113 , 114 , 115 ] have been indicated to be associated with drug resistance in cancers. ceRNAs can play important roles in the regulation of autophagy-mediated chemoresistance in cancers.…”

Section: Cerna-mediated Autophagy and Chemoresistancementioning

confidence: 99%

The Roles of ceRNAs-Mediated Autophagy in Cancer Chemoresistance and Metastasis

Zhang

Lü

2020

Cancers

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Chemoresistance and metastasis are the main causes of treatment failure and unfavorable outcome in cancers. There is a pressing need to reveal their mechanisms and to discover novel therapy targets. Autophagy is composed of a cascade of steps controlled by different autophagy-related genes (ATGs). Accumulating evidence suggests that dysregulated autophagy contributes to chemoresistance and metastasis via competing endogenous RNA (ceRNA) networks including lncRNAs and circRNAs. ceRNAs sequester the targeted miRNA expression to indirectly upregulate ATGs expression, and thereof participate in autophagy-mediated chemoresistance and metastasis. Here, we attempt to summarize the roles of ceRNAs in cancer chemoresistance and metastasis through autophagy regulation.

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“…Such characteristic induces the property of circRNAs, covering microRNA(miRNA) sponge, showing an interaction to RNA-binding proteins (RBPs), and encoding proteins that has been recently identified [2]. CircRNAs are found to impact considerable physiological and pathology processes, covering regulated cell death, metabolism, cancer, as well as drug resistance [3][4][5]. Besides, circRNAs can be up-regulated and stable in exosomes, which has increased opportunities for intercellular communication [6].…”

Section: Introductionmentioning

confidence: 99%

The emerging landscape of circular RNAs in immunity: breakthroughs and challenges

Cheng

et al. 2020

Biomark Res

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Circular RNAs (circRNAs) are covalently linked RNAs that exhibit individual strand with a closed-loop framework compared with a conserving, steady and abundant linear counterpart. In recent years, as high-throughput sequencing advancement has been developing, functional circRNAs have been increasingly recognized, and more extensive analyses expounded their effect on different diseases. However, the study on the function of circRNAs in the immune system remains insufficient. This study discusses the basic principles of circRNAs regulation and the systems involved in physiology-related and pathology-related processes. The effect of circRNAs on immune regulation is elucidated. The ongoing development of circRNAs and basic immunology has multiplied their potential in treating diseases. Such perspective will summarize the status and effect of circRNAs on various immune cells in cancer, autoimmune diseases and infections. Moreover, this study will primarily expound the system of circRNAs in T lymphocytes, macrophages and other immune cells, which creates a novel perspective and lay a theoretical basis for treating diseases.

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Functions and mechanisms of circular RNAs in cancer radiotherapy and chemotherapy resistance

Cited by 147 publications

References 164 publications

CircRNAs in anticancer drug resistance: recent advances and future potential

CircRNAs in anticancer drug resistance: recent advances and future potential

The Roles of ceRNAs-Mediated Autophagy in Cancer Chemoresistance and Metastasis

The emerging landscape of circular RNAs in immunity: breakthroughs and challenges

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