Functions of ‘A disintegrin and metalloproteases (ADAMs)’ in the mammalian nervous system

Hsia, Hung‐En; Tüshaus, Johanna; Brummer, Tobias; Zheng, Yuanpeng; Scilabra, Simone D.; Lichtenthaler, Stefan F.

doi:10.1007/s00018-019-03173-7

Cited by 98 publications

(80 citation statements)

References 262 publications

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“…By the end of the lactation period (PPD 22) only a few perisomatic PNNs positive cells are still present with a surrounding interneuronal diffuse staining. These results suggest a complex PNNs degradation process probably involving the action of matrix metalloproteinases 66 , an underlying mechanism for a programmed PNNs degradation, or a passive mechanism of disassembly combined with transient synthesis events.…”

Section: The Pnns Expression In the Mpoa Persists After Parturition mentioning

confidence: 85%

Reorganization of perineuronal nets in the medial Preoptic Area during the reproductive cycle in female rats

Uriarte

Ferreño

Mendez

et al. 2020

Sci Rep

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Perineuronal nets (PNNs) are aggregations of extracellular matrix associated with specific neuronal populations in the central nervous system, suggested to play key roles in neural development, synaptogenesis and experience-dependent synaptic plasticity. pregnancy and lactation are characterized by a dramatic increase in neuroplasticity. However, dynamic changes in the extracellular matrix associated with maternal circuits have been mostly overlooked. We analyzed the structure of pnns in an essential nucleus of the maternal circuit, the medial preoptic area (mpoA), during the reproductive cycle of rats, using the Wisteria floribunda (WfA) label. pnns associated to neurons in the mpoA start to assemble halfway through gestation and become highly organized prior to parturition, fading through the postpartum period. this high expression of pnns during pregnancy appears to be mediated by the influence of estrogen, progesterone and prolactin, since a hormonal simulatedgestation treatment induced the expression of pnns in ovariectomized females. We found that pnns associated neurons in the mpoA express estrogen receptor α and progesterone receptors, supporting a putative role of reproductive hormones in the signaling mechanisms that trigger the assembly of PNNs in the mPOA. This is the first report of PNNs presence and remodeling in mPOA during adulthood induced by physiological variables.

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Section: The Pnns Expression In the Mpoa Persists After Parturition mentioning

confidence: 85%

Reorganization of perineuronal nets in the medial Preoptic Area during the reproductive cycle in female rats

Uriarte

Ferreño

Mendez

et al. 2020

Sci Rep

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“…ADAM9, a type I transmembrane protein, is a catalytically active metalloprotease-disintegrin protein involved in multiple biological processes (Oria et al, 2018;Hsia et al, 2019). Specifically, ADAM9 acts as an α-secretase to cleave APP in nonamyloidogenic pathway producing sAPPα (Koike et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

Caspr1 Facilitates sAPPα Production by Regulating α-Secretase ADAM9 in Brain Endothelial Cells

Tang

Liu

et al. 2020

Front. Mol. Neurosci.

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“…However, further experiments have to include various substrates of ADAM10 and ADAM17 to avoid many deleterious consequences by activating these enzymes. Moreover, additional experiments are needed to clearly show that the major target of E144 is ADAM17 over ADAM10 since it has been reported that ADAM17-mediated alpha cleavage of APP, referred to as the "regulated" pathway, is mostly occurring when PKC is stimulated [13,15,16]. Since activation of GPCR can increase APP processing by α-secretase via ADAM17 [13], the effect of E144 on ADAM17 may occur through GPCR signaling.…”

Section: Discussionmentioning

confidence: 99%

“…Among three family members, ADAM10 is considered as sheddase for APP and other diverse cell-surface proteins, including cytokines, cell adhesion molecules (CAMs), and Notch [13,14]. In contrast, ADAM9 and ADAM17 are believed to undertake regulated APP cleavage [13,15,16]. However, several studies demonstrated that ADAM9 could mimic the constitutive function of ADAM10 in microglia cells [17,18].…”

mentioning

confidence: 99%

Substrate-Specific Activation of α-Secretase by 7-Deoxy-Trans-Dihydronarciclasine Increases Non-Amyloidogenic Processing of β-Amyloid Protein Precursor

et al. 2020

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Accumulation of β-amyloid (Aβ) in the brain has been implicated in the pathology of Alzheimer’s disease (AD). Aβ is produced from the Aβ precursor protein (APP) through the amyloidogenic pathway by β-, and γ-secretase. Alternatively, APP can be cleaved by α-, and γ-secretase, precluding the production of Aβ. Thus, stimulating α-secretase mediated APP processing is considered a therapeutic option not only for decreasing Aβ production but for increasing neuroprotective sAPPα. We have previously reported that 7-deoxy-trans-dihydronarciclasine (E144), the active component of Lycoris chejuensis, decreases Aβ production by attenuating APP level, and retarding APP maturation. It can also improve cognitive function in the AD model mouse. In this study, we further analyzed the activating effect of E144 on α-secretase. Treatment of E144 increased sAPPα, but decreased β-secretase products from HeLa cells stably transfected with APP. E144 directly activated ADAM10 and ADAM17 in a substrate-specific manner both in cell-based and in cell-free assays. The Lineweaver–Burk plot analysis revealed that E144 enhanced the affinities of A Disintegrin and Metalloproteinases (ADAMs) towards the substrate. Consistent with this result, immunoprecipitation analysis showed that interactions of APP with ADAM10 and ADAM17 were increased by E144. Our results indicate that E144 might be a novel agent for AD treatment as a substrate-specific activator of α-secretase.

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Functions of ‘A disintegrin and metalloproteases (ADAMs)’ in the mammalian nervous system

Cited by 98 publications

References 262 publications

Reorganization of perineuronal nets in the medial Preoptic Area during the reproductive cycle in female rats

Reorganization of perineuronal nets in the medial Preoptic Area during the reproductive cycle in female rats

Caspr1 Facilitates sAPPα Production by Regulating α-Secretase ADAM9 in Brain Endothelial Cells

Substrate-Specific Activation of α-Secretase by 7-Deoxy-Trans-Dihydronarciclasine Increases Non-Amyloidogenic Processing of β-Amyloid Protein Precursor

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