Functions of CD169 positive macrophages in human diseases (Review)

Liu, Yu; Yuan, Xia; Qiu, Chun-Hong

doi:10.3892/br.2020.1402

Cited by 32 publications

(33 citation statements)

References 106 publications

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“…The role of CD169+ macrophages in immune regulation and human diseases has been widely reported [2]. In viral infections, CD169+ macrophages resident in lymphoid organs are the first cells that bind incoming pathogens and act as guardians to prevent their further spread.…”

Section: Discussionmentioning

confidence: 99%

“…In response to SARS-CoV-2 infection, host cells immediately produce cytokines including type I interferon (IFN-I that, in addition to carrying out its antiviral activity, also induces the expression of genes involved in limiting the viral spread. After antiviral cytokines are released, the sialoadhesin CD169 (also known as SIGLEC-1) is induced and expressed on the surface of myeloid lineage cells, such as dendritic cells and monocytes, [2,3]. In particular, two-fold upregulation of CD169 has been observed in monocytes (mCD169) exposed in vitro to IFNα [4].…”

Section: Graphical Abstract Introductionmentioning

confidence: 99%

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High CD169 Monocyte/Lymphocyte Ratio Reflects the Immunophenotyping Disruption and Predicts Oxygen Need in COVID-19 Patients

Minutolo¹,

Petrone²,

Fanelli³

et al. 2021

Preprint

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Background: CD169 has been found overexpressed in the blood of COVID-19 patients and identified as a biomarker in the early disease. We have analysed CD169 in blood cells of COVID-19 patients to assess its role as predictive marker of the disease. Methods : The ratio of the CD169 Median median Fluorescence fluorescence Intensity intensity of CD169 between monocytes and lymphocytes (CD169 RMFI ) was analysed by flow cytometry in blood samples of COVID-19 patients (COV) and healthy donors (HD ) and correlated with immunophenotyping, inflammatory markers, cytokines mRNA expression, pulmonary involvement and disease progression. Results: CD169 RMFI increased in COV but not in HD. CD169 RMFI correlated with T-cell differentiation and exhaustion markers as well as with B cells maturation and differentiation. In vitro stimulation of PBMCs of HD with SARS-CoV-2 Spike spike protein induced CD169 RMFI together with IL-6 and IL-10 gene expression. Likewise, CD169 RMFI correlated with blood cytokine mRNA levels, inflammatory markers, and pneumonia severity in patients which that had not received any treatment at sampling. Notably, in untreated patients, CD169 RMFI reflected the respiratory outcome during hospitalization. Conclusion : Considering the immunological role of CD169 and its involvement during the infection and the progression of COVID-19, it could be considered as an early biomarker to evaluate disease progression and clinical outcome.

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Section: Discussionmentioning

confidence: 99%

Section: Graphical Abstract Introductionmentioning

confidence: 99%

High CD169 Monocyte/Lymphocyte Ratio Reflects the Immunophenotyping Disruption and Predicts Oxygen Need in COVID-19 Patients

Minutolo¹,

Petrone²,

Fanelli³

et al. 2021

Preprint

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show abstract

“…In response to SARS-CoV-2 infection, host cells immediately produce cytokines, including type I interferon (IFN-I), which, in addition to showing antiviral activity, induces the expression of genes involved in limiting the viral spread. After antiviral cytokines are released, sialoadhesin (CD169, also known as SIGLEC-1) is induced and expressed on the surfaces of myeloid lineage cells, such as dendritic cells and monocytes [ 5 , 6 ]. In particular, the two-fold upregulation of CD169 in monocytes (mCD169) exposed to IFNα in vitro has been observed [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

High CD169 Monocyte/Lymphocyte Ratio Reflects Immunophenotype Disruption and Oxygen Need in COVID-19 Patients

et al. 2021

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Background: Sialoadhesin (CD169) has been found to be overexpressed in the blood of COVID-19 patients and identified as a biomarker in early disease. We analyzed CD169 in the blood cells of COVID-19 patients to assess its role as a predictive marker of disease progression and clinical outcomes. Methods: The ratio of the median fluorescence intensity of CD169 between monocytes and lymphocytes (CD169 RMFI) was analyzed by flow cytometry in blood samples of COVID-19 patients (COV) and healthy donors (HDs) and correlated with immunophenotyping, inflammatory markers, cytokine mRNA expression, pulmonary involvement, and disease progression. Results: CD169 RMFI was high in COV but not in HDs, and it correlated with CD8 T-cell senescence and exhaustion markers, as well as with B-cell maturation and differentiation in COV. CD169 RMFI correlated with blood cytokine mRNA levels, inflammatory markers, and pneumonia severity in patients who were untreated at sampling, and was associated with the respiratory outcome throughout hospitalization. Finally, we also report the first evidence of the specific ability of the spike protein of SARS-CoV-2 to trigger CD169 RMFI in a dose-dependent manner in parallel with IL-6 and IL-10 gene transcription in HD PBMCs stimulated in vitro. Conclusion: CD169 is induced by the spike protein and should be considered as an early biomarker for evaluating immune dysfunction and respiratory outcomes in COVID-19 patients.

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“…A Th1-like immune environment is generally believed to induce M1(-like) macrophage polarization, whereas a Th2-like immune environment induces M2(-like) macrophage polarization. SMs express both M1-and M2-related genes, making these cells unsuitable for M1/M2 classification [31]. In addition to M1/M2 classification, macrophages can be categorized into two types depending on origin: monocyte-derived macrophages and tissue-resident macrophages derived from hematopoietic precursors in the embryonic yolk sac or fetal liver at birth [32][33][34].…”

Section: Potential Origin Of Sms In Micementioning

confidence: 99%

Anti-Cancer Immune Reaction and Lymph Node Macrophage; A Review from Human and Animal Studies

Komohara

Anami

Asano

et al. 2021

Immuno

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Lymph nodes are secondary lymphoid organs that appear as bean-like nodules usually <1 cm in size, and they are localized throughout the body. Many antigen-presenting cells such as dendritic cells and macrophages reside in lymph nodes, where they mediate host defense responses against pathogens such as viruses and bacteria. In cancers, antigen-presenting cells induce cytotoxic T lymphocytes (CTLs) to react to cancer cell-derived antigens. Macrophages located in the lymph node sinus are of particular interest in relation to anti-cancer immune responses because many studies using both human specimens and animal models have suggested that lymph node macrophages expressing CD169 play a key role in activating anti-cancer CTLs. The regulation of lymph node macrophages therefore represents a potentially promising novel approach in anti-cancer therapy.

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Functions of CD169 positive macrophages in human diseases (Review)

Cited by 32 publications

References 106 publications

High CD169 Monocyte/Lymphocyte Ratio Reflects the Immunophenotyping Disruption and Predicts Oxygen Need in COVID-19 Patients

High CD169 Monocyte/Lymphocyte Ratio Reflects the Immunophenotyping Disruption and Predicts Oxygen Need in COVID-19 Patients

High CD169 Monocyte/Lymphocyte Ratio Reflects Immunophenotype Disruption and Oxygen Need in COVID-19 Patients

Anti-Cancer Immune Reaction and Lymph Node Macrophage; A Review from Human and Animal Studies

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