Functions of LncRNAs, exosomes derived MSCs and immune regulatory molecules in preeclampsia disease

Al-Hawary, Sulieman Ibraheem Shelash; Tayyib, Nahla A.; Ramaiah, Pushpamala; Parra, Rosario Mireya Romero; Ibrahim, Ahmed jaber; Mustafa, Yasser Fakri; Hussien, Beneen M.; Alsulami, Sana A.; Baljon, Kamilya Jamel; Nomani, Ibtesam

doi:10.1016/j.prp.2023.154795

Cited by 1 publication

(1 citation statement)

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“…Some lncRNAs have been reported to encode various functional peptides or polypeptides that play specific biological roles. Abnormal expression and function of lncRNAs are closely associated with human diseases, including cancer, psychiatric disorders, and autoimmune diseases, among others ( 14 , 15 ). Most studies have focused on evaluating the expression profiles of non-coding RNAs in synovial cells, tissues, or synovial fluids of patients with RA.…”

Section: Introductionmentioning

confidence: 99%

Serum exosomes lncRNAs: TCONS_I2_00013502 and ENST00000363624 are new diagnostic markers for rheumatoid arthritis

Wu,

Chen,

Wang

et al. 2024

Front. Immunol.

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The lack of diagnostic markers limits the window of effectiveness for rheumatoid arthritis (RA) therapies. Here, we isolated exosomes of serum samples from four distinct groups RA patients, according to disease activity and with/without medication. Then, total RNA of exosomes was extracted for whole-transcriptome sequencing. Focusing on lncRNA sequencing, gene ontology (GO) and kyoto encyclopedia of genes and genomes (KEGG) pathway enrichment analyses were performed. We found that the number of upregulated lncRNAs were significantly higher than that of downregulated lncRNAs in each four RA groups. And most importantly, we identified two specific lncRNAs from differentially expressed lncRNAs, TCONS_I2_00013502 (up-regulated) and ENST00000363624 (down-regulated) in RA. Receiver Operating Characteristic (ROC) curve analysis showed that the two lncRNAs were promising biomarkers for RA diagnosis. These findings highlight lncRNAs of the serum exosome are important biomarkers and provide application potential for diagnosis of RA.

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Section: Introductionmentioning

confidence: 99%