2020
DOI: 10.3390/ijms21197018
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Functions of Small Organic Compounds that Mimic the HNK-1 Glycan

Abstract: Because of the importance of the HNK-1 carbohydrate for preferential motor reinnervation after injury of the femoral nerve in mammals, we screened NIH Clinical Collection 1 and 2 Libraries and a Natural Product library comprising small organic compounds for identification of pharmacologically useful reagents. The reason for this attempt was to obviate the difficult chemical synthesis of the HNK-1 carbohydrate and its isolation from natural sources, with the hope to render such compounds clinically useful. We i… Show more

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Cited by 4 publications
(9 citation statements)
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“…In this way, NRP1 and 2 interact with SEMA3 membrane-associated receptors located in the central nervous system (plexins) and their growth factors (class 3 semaphorins) [101][102][103]. In addition, they bind to a series of growth factor s and their receptors, including VEGF/VEGFR [75,76,[104][105][106], TGF-β1/TGFβ1R [107,108], HGF/c-Met [109,110], PDGF/PDGFR [111][112][113], FGFs/FGFR [112,[114][115][116][117], EGF/EGFR, BDNF/TRKA,B [118] as well as IGF/INSR [119]. These interactions favor the growth of potential tumor cells (Figure 3a,b).…”
Section: Physiologic Role Of Poly/oligo-sialylated Adhesion Molecules and Their Interaction With Growth Factors And Their Receptorsmentioning
confidence: 99%
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“…In this way, NRP1 and 2 interact with SEMA3 membrane-associated receptors located in the central nervous system (plexins) and their growth factors (class 3 semaphorins) [101][102][103]. In addition, they bind to a series of growth factor s and their receptors, including VEGF/VEGFR [75,76,[104][105][106], TGF-β1/TGFβ1R [107,108], HGF/c-Met [109,110], PDGF/PDGFR [111][112][113], FGFs/FGFR [112,[114][115][116][117], EGF/EGFR, BDNF/TRKA,B [118] as well as IGF/INSR [119]. These interactions favor the growth of potential tumor cells (Figure 3a,b).…”
Section: Physiologic Role Of Poly/oligo-sialylated Adhesion Molecules and Their Interaction With Growth Factors And Their Receptorsmentioning
confidence: 99%
“…In this way, NRP1 and 2 interact with SEMA3 membrane-associated receptors located in the central nervous system (plexins) and their growth factors (class 3 semaphorins) [101][102][103]. In addition, they bind to a series of growth factor s and their receptors, including VEGF/VEGFR [75,76,[104][105][106], TGF-β1/TGFβ1R [107,108], HGF/c-Met [109,110], PDGF/PDGFR [111][112][113], FGFs/FGFR [112,[114][115][116][117], EGF/EGFR, BDNF/ TRKA,B [118] as well as IGF/INSR [119]. These interactions favor the growth of potential tumor cells (Figure 3a (growth factor) receptors including (from left to right) PTK7 (pseudo tyrosine kinase, receptor7, CCK4), VEGFR1/2/3 (vascular endothelial growth factor receptor 1/2/3), PDGFRα/β ( platelet derived growth factor receptor α/β; CSF1R, KIT, FLK2), FGFR1/2/3/4 (fibroblast growth factor receptor 1/2/3/4), c-Met (tyrosine-protein kinase Met or hepatocyte growth factor receptor (HGFR); Ron, Sea), TrKA/B (tropomyosin receptor kinase A/B), RORα/β (RAR (retinoic acid receptor)-related orphan receptor-α/β), MuSK (muscle-specific kinase), TieR1/2 (tyrosine kinase with immunoglobulin-like and EGF-like domains 1/2, angiopoietin receptor), and AXL (AXL receptor tyrosine kinase).…”
Section: Physiologic Role Of Poly/oligo-sialylated Adhesion Molecules and Their Interaction With Growth Factors And Their Receptorsmentioning
confidence: 99%
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“…We had previously identified small organic compounds that are part of the human diet or are FDA-approved molecules that mimic regenerative-beneficial properties after neurotrauma [ 1 , 2 , 3 ]. We followed up on these results to investigate these compounds in more detail regarding the functions of adhesion molecules, glycans, and their binding partners.…”
Section: Introductionmentioning
confidence: 99%
“…Peripheral nerve injury (PNI), which disturbs behavioral function and reduces quality of life, has emerged as a major problem in rehabilitation medicine [1,2]. In contrast to the central nervous system, the peripheral nervous system exhibits a significant self-repair and regenerative capacity following peripheral nerve injury [3,4]. However, complex injuries with substantial loss of nerve tissue and a subsequent defect between the nerve ends often require therapeutic intervention for functional restoration.…”
Section: Introductionmentioning
confidence: 99%