Functions of the endothelium and its role in hematopoietic cell transplantation

Macrophage‐derived exosomal miR‐4532 promotes endothelial cells injury by targeting SP1 and NF‐κB P65 signalling activation

“… 1 , 2 Endothelial cells constitute physiological barriers, which sustain normal vascular function. 3 High glucose, circulating low‐density lipoprotein or Apolipoprotein B, accumulate beneath the vascular endothelial cell layer and recruit macrophages to participate in a series of adverse, non‐resolving inflammatory reactions that accelerate endothelial inflammatory responses and promote atherosclerotic plaque formation. 4 Recent research has verified that nitric oxide synthase 1‐derived nitric oxide and the small heat shock protein, HSP27, are involved in macrophage and endothelial cell interaction and related to apoptosis and autophagy.…”

“…Atherosclerosis is the main cause of coronary heart disease, cerebral infarction and peripheral vascular diseases 1,2 . Endothelial cells constitute physiological barriers, which sustain normal vascular function 3 . High glucose, circulating low‐density lipoprotein or Apolipoprotein B, accumulate beneath the vascular endothelial cell layer and recruit macrophages to participate in a series of adverse, non‐resolving inflammatory reactions that accelerate endothelial inflammatory responses and promote atherosclerotic plaque formation 4 .…”

“…1,2 Endothelial cells constitute physiological barriers, which sustain normal vascular function. 3 High glucose, circulating low-density lipoprotein or Apolipoprotein B, accumulate beneath the vascular endothelial cell layer and recruit macrophages to participate in a series of adverse,…”