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Cited by 23 publications
(32 citation statements)
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References 244 publications
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“…One emerging regulator of CSC function is the cellular prion protein PrP C [8], which is infamous for its involvement in a group of neurodegenerative diseases under its pathogenic scrapie isoform [9]. PrP C is a ubiquitous protein mainly found as a GPI-anchored cell surface molecule and also present in the extracellular space as a soluble isoform [10]. PrP C can interact with promiscuous partners and mobilize cell signalling cascades [10], which make it an interesting candidate to sense the tumour microenvironment and foster an adaptive response in cancer cells.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…One emerging regulator of CSC function is the cellular prion protein PrP C [8], which is infamous for its involvement in a group of neurodegenerative diseases under its pathogenic scrapie isoform [9]. PrP C is a ubiquitous protein mainly found as a GPI-anchored cell surface molecule and also present in the extracellular space as a soluble isoform [10]. PrP C can interact with promiscuous partners and mobilize cell signalling cascades [10], which make it an interesting candidate to sense the tumour microenvironment and foster an adaptive response in cancer cells.…”
Section: Introductionmentioning
confidence: 99%
“…PrP C is a ubiquitous protein mainly found as a GPI-anchored cell surface molecule and also present in the extracellular space as a soluble isoform [10]. PrP C can interact with promiscuous partners and mobilize cell signalling cascades [10], which make it an interesting candidate to sense the tumour microenvironment and foster an adaptive response in cancer cells.…”
Section: Introductionmentioning
confidence: 99%
“…PrP C is located within lipid rafts [3,4], sphingolipid-rich membrane micro domains, and it is present in several kind of cells such as neural and lymphocytic cells [5,6,7]. The membrane-bound isoform can act as a cell surface receptor, or as a co-receptor, recruiting downstream signal transduction pathways [8,9,10,11]. PrP C is involved in a wide range of cellular processes, such as synaptic plasticity, neurite regulation, calcium homeostasis, copper metabolism, apoptosis and cellular resistance to oxidative stress [12,13,14,15,16].…”
Section: Introductionmentioning
confidence: 99%
“…This would fit in with the protective role ascribed to PrP C in the context of various types of stresses (see ref. 9 for review). Conversely, in the context of CKD, our results suggest that high PrP C levels are associated with worse renal function.…”
Section: Discussionmentioning
confidence: 99%
“…Here, we investigated if the soluble form of the ER stress-inducible protein, prion protein (PrP C ) is also a candidate urinary ER stress biomarker. The cellular prion protein PrP C , which is involved in the pathophysiology of some neurodegenerative diseases under its pathogenic scrapie isoform, is a ubiquitous protein mainly found as a GPI-anchored cell surface molecule and present in the extracellular space as a soluble isoform 9 . The aim of this study was to determine whether PrP C could serve as a urinary ER stress biomarker for ER stress-mediated kidney diseases by studying a combination of cellular models and human patient samples.…”
Section: Introductionmentioning
confidence: 99%