Fundamental Characteristics of a Glucose Transistor with a Chemically Functional Interface

Uematsu, Yuta; Kajisa, Taira; Sakata, Toshiya

doi:10.1002/celc.201700419

Cited by 11 publications

(9 citation statements)

References 41 publications

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“…On the other hand, is shown to be the actual driving force of an ion-sensitive field-effect transistor (ISFET) with the Ta 2 O 5 membrane, which is related to the logarithm of H + concentration by the following equations [29]: …”

Section: Resultsmentioning

confidence: 99%

Biocompatible and flexible paper-based metal electrode for potentiometric wearable wireless biosensing

Sakata

Hagio

Saito

et al. 2020

Science and Technology of Advanced Materials

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A paper-based electrode is a very attractive component for a disposable, nontoxic, and flexible biosensor. In particular, wearable biosensors, which have recently been attracting interest, not only require these characteristics of paper-based electrodes but must also be able to detect various ions and biomolecules in biological fluids. In this paper, we demonstrate the detection ability of paper-based metal electrodes for wearable biosensors as part of a wireless potentiometric measurement system, focusing on the detection of pH and sodium ions. The paperbased metal electrodes were obtained by simply coating a silicone-rubber-coated paper sheet with a Au (/Cr) thin film by sputtering then modifying it with different functional membranes such as an oxide membrane (Ta 2 O 5) and a fluoropolysilicone (FPS)-based Na +-sensitive membrane, corresponding to the targeted ions. Satisfactory and stable detection sensitivities of the modified paper-based Au electrodes were obtained over several weeks even when they were bent to a radius of curvature in the range of 6.5 to 25 mm, assuming use in a flexible body patch biosensor. Moreover, the Na + concentration in a sweat sample was evaluated using the paperbased Au electrode with the FPS-based Na +-sensitive membrane in a wireless and real-time manner while the electrode was bent. Thus, owing to their complex mesh structure, flexible paper sheets should be suitable for use as potentiometric electrodes for wearable wireless biosensors.

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Section: Resultsmentioning

confidence: 99%

Biocompatible and flexible paper-based metal electrode for potentiometric wearable wireless biosensing

Sakata

Hagio

Saito

et al. 2020

Science and Technology of Advanced Materials

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“…It is worth noting that the obtained sensitivity is low if compared to the limiting value of 59 mV/decade, expected if biomolecule binding would follow the Nernstian model of equilibrium potentials of ions across semipermeable membranes [17]. Such an extreme value has been previously reported for glucose [37] and urea [32] BioFETs with gold EG. However, there are significant differences between proton equilibria and macrobiomolecule binding equilibria, which imply that the Nernst model would not apply to protein binding [17].…”

Section: Response To P53 Wt : Extended-gate Surface Potential Changes and Detection Limitmentioning

confidence: 66%

A Reliable BioFET Immunosensor for Detection of p53 Tumour Suppressor in Physiological-Like Environment

Baldacchini

Montanarella

Francioso

et al. 2020

Sensors

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The concentration of wild-type tumour suppressor p53wt in cells and blood has a clinical significance for early diagnosis of some types of cancer. We developed a disposable, label-free, field-effect transistor-based immunosensor (BioFET), able to detect p53wt in physiological buffer solutions, over a wide concentration range. Microfabricated, high-purity gold electrodes were used as single-use extended gates (EG), which avoid direct interaction between the transistor gate and the biological solution. Debye screening, which normally hampers target charge effect on the FET gate potential and, consequently, on the registered FET drain-source current, at physiological ionic strength, was overcome by incorporating a biomolecule-permeable polymer layer on the EG electrode surface. Determination of an unknown p53wt concentration was obtained by calibrating the variation of the FET threshold voltage versus the target molecule concentration in buffer solution, with a sensitivity of 1.5 ± 0.2 mV/decade. The BioFET specificity was assessed by control experiments with proteins that may unspecifically bind at the EG surface, while 100pM p53wt concentration was established as limit of detection. This work paves the way for fast and highly sensitive tools for p53wt detection in physiological fluids, which deserve much interest in early cancer diagnosis and prognosis.

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“…The extended-gate ISFET sensor was used for monitoring a self-oscillation behavior of a polymer brush grafted to the Ta 2 O 5 gate surface. In this case, Ta 2 O 5 film (100 nm) with the surface area of 12 12 mm 2 was sputtered on a Au (100 nm)/Cr (20 nm) electrode, which was connected to the gate of a silicon-based n-channel junction-type FET (K246-Y9A, Toshiba), as an extended-gate electrode, considering ease of surface treatments 42 , 43 .…”

Section: Methodsmentioning

confidence: 99%

Self-oscillating chemoelectrical interface of solution-gated ion-sensitive field-effect transistor based on Belousov–Zhabotinsky reaction

Sakata

Nishitani

Yasuoka

et al. 2022

Sci Rep

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The Belousov–Zhabotinsky (BZ) self-oscillation reaction is an important chemical model to elucidate nonequilibrium chemistry in an open system. However, there are only a few studies on the electrical behavior of pH oscillation induced by the BZ reaction, although numerous studies have been carried out to investigate the mechanisms by which the BZ reaction interacts with redox reactions, which results in potential changes. Needless to say, the electrical characteristic of a self-oscillating polymer gel driven by the BZ reaction has not been clarified. On the other hand, a solution-gated ion-sensitive field-effect transistor (ISFET) has a superior ability to detect ionic charges and includes capacitive membranes on the gate electrode. In this study, we carried out the electrical monitoring of self-oscillation behaviors at the chemoelectrical interface based on the BZ reaction using ISFET sensors, focusing on the pH oscillation and the electrical dynamics of the self-oscillating polymer brush. The pH oscillation induced by the BZ reaction is not only electrically observed using the ISFET sensor, the electrical signals of which results from the interfacial potential between the solution and the gate insulator, but also visualized using a large-scale and high-density ISFET sensor. Moreover, the N-isopropylacrylamide (NIPAAm)-based self-oscillating polymer brush with Ru(bpy)3 as a catalyst clearly shows a periodic electrical response based on the swelling–deswelling behavior caused by the BZ reaction on the gate insulator of the ISFET sensor. Thus, the elucidation of the electrical self-oscillation behaviors induced by the BZ reaction using the ISFET sensor provides a solution to the problems of nonequilibrium chemistry.

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Fundamental Characteristics of a Glucose Transistor with a Chemically Functional Interface

Cited by 11 publications

References 41 publications

Biocompatible and flexible paper-based metal electrode for potentiometric wearable wireless biosensing

Biocompatible and flexible paper-based metal electrode for potentiometric wearable wireless biosensing

A Reliable BioFET Immunosensor for Detection of p53 Tumour Suppressor in Physiological-Like Environment

Self-oscillating chemoelectrical interface of solution-gated ion-sensitive field-effect transistor based on Belousov–Zhabotinsky reaction

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