2017
DOI: 10.14814/phy2.13214
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Fundamental hemodynamic mechanisms mediating the response to myocardial ischemia in conscious paraplegic mice: cardiac output versus peripheral resistance

Abstract: Autonomic dysfunction, a relative sedentary lifestyle, a reduced muscle mass and increased adiposity leads to metabolic abnormalities that accelerate the development of coronary artery disease (CAD) in individuals living with spinal cord injury (SCI). An untoward cardiac incident is related to the degree of CAD, suggesting that the occurrence of a significant cardiac event is significantly higher for individuals with SCI. Thus, understanding the fundamental hemodynamic mechanisms mediating the response to myoc… Show more

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Cited by 6 publications
(9 citation statements)
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“…). Importantly, in both of these injury models the lack of descending control to the splanchnic region reduces stroke volume and has recently been shown to cause significantly dysfunctional haemodynamic responses to coronary ischaemia (Lujan & DiCarlo, , ). Put together, these findings suggest that the global systolic dysfunction observed in experimental SCI is heavily dependent on descending sympatho‐excitatory control.…”
Section: Introductionmentioning
confidence: 99%
“…). Importantly, in both of these injury models the lack of descending control to the splanchnic region reduces stroke volume and has recently been shown to cause significantly dysfunctional haemodynamic responses to coronary ischaemia (Lujan & DiCarlo, , ). Put together, these findings suggest that the global systolic dysfunction observed in experimental SCI is heavily dependent on descending sympatho‐excitatory control.…”
Section: Introductionmentioning
confidence: 99%
“…Next, a coronary artery occluder was passed around the left main coronary artery as recently described in mice (Lujan et al. ; Lujan and DiCarlo , , ). The two ends of the vascular occluder were passed through guide tubing and exited at the dorsal aspect of the neck (Lujan et al.…”
Section: Methodsmentioning
confidence: 99%
“…Subsequently, to record arterial blood pressure, a catheter from a telemetry device (Data Sciences International, PA‐C10) was placed into the left carotid artery and advanced to the aortic arch (Kurtz et al. ; Lujan and DiCarlo ). The transmitter body was positioned subcutaneously on the left side.…”
Section: Methodsmentioning
confidence: 99%
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