Fundamental imaging properties of transillumination laser CT using optical fiber applicable to bio-medical sensing

Sasaki, Y.; Tanosaki, Shinji; Suzuki, Jota; Yuasa, Tetsuya; Taniguchi, Hiroshi; Devaraj, B.; Akatsuka, Takao

doi:10.1109/jsen.2003.817168

Cited by 13 publications

(4 citation statements)

References 27 publications

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“…Hence, the image was subject to motion artifacts due to twisting, expansion, and contraction of the finger that occurred due to the movement of the stage, and the reconstructed image quality is degraded. Presently, we are developing the fiber optic system [18]. In the newly proposed system, the measurements can be performed with the finger fixed.…”

Section: Resultsmentioning

confidence: 99%

“…Originally, the CDI method based on the optical heterodyne detection technique for laser tomography of biological tissues in the transillumination mode was devised and realized by Inaba and co-workers [12]. They had demonstrated its effectiveness for biomedical imaging, and reported tomographic images of various biological samples both in vitro and in vivo [13][14][15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

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Finger joint imaging by laser transillumination computed tomography based on coherent detection imaging method

et al. 2003

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In this research, we investigate the imaging properties of tansillumination laser CT system based on the coherent detection imaging (CDI) method, for early diagnosis of rheumatoid arthritis, from the viewpoints of morphological and quantitative imaging. First, to investigate the morphological imaging ability, the index finger PIP joint of a healthy volunteer was imaged with the laser CT, X-ray CT, and MRI. By comparison of these images, we present that the laser CT delineates the bone region with high spatial resolution of sub-millimeters. Next, to investigate the quantitative imaging, three kinds of the physical phantoms simulating bone, made from polyurethane including different concentrations of CaCO 3 , were imaged. We present that quantitative measurement is possible by demonstrating a satisfactory linear relationship between the averaged pixel value of the reconstructed images and the actual concentrations. These results demonstrate the feasibility of early diagnosis for rheumatoid arthritis.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Finger joint imaging by laser transillumination computed tomography based on coherent detection imaging method

et al. 2003

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“…43,44 Examples of the application of CDI in biomedical transillumination include polarization gating methods for imaging through turbid media, 45 measurement of Wigner phasespace distributions for biomedical applications, 46 and transillumination computed tomography for biomedical sensing. 47,48 As mentioned before, diverse methods may be utilized for pass-through photon-based transillumination diagnosis. In our approach, we have suggested a time-domain interferometric system, shown schematically in Fig.…”

Section: Introductionmentioning

confidence: 99%

Pass-through photon-based biomedical transillumination

2008

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We present the mathematical foundation and the experimental validation of a technique that utilizes pass-through (ballistic) photons in a partial coherence interferometric transillumination setup for biomedical analyses. We demonstrate that the implementation depends closely on tissue under test, incident power, spatial and spectral characteristics of the radiation source, and detection electronics. With the aid of the complex material coherence function concept, we foresee tissue characterization and diagnostic imaging as potential applications for the technique. We propose a normalization procedure for in vitro and in vivo measurements, where nontissue-related quantities are canceled out. The validation of the proposal is achieved by obtaining the sample coherence function of a tissue phantom. The expected exponential attenuation is confirmed, and the corresponding scattering coefficients are determined. A good agreement between theory and experiment, for the initial set of samples, serves to establish that pass-through photon-based transillumination is feasible for selected biomedical applications.

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“…Our group had so far developed a transillumination laser CT imaging method based on the CDI method in the visible and near-infrared regions and reconstruction from projections, and reported a variety of tomographic images both in vitro and in vivo of biological objects to demonstrate the effectiveness to biomedical use [11][12][13][14][15][16][17][18][19][20]. Especially, in the course of our research, we have proposed , through various preliminary experiments with small-animal ankle's and human finger's joints both healthy and joint-diseased, that early diagnosis of joint disease such as rheumatoid arthritis is feasible using the laser CT. We have so far delineated a cross section at the level of the human finger joint [14,[16][17], using our conventional free-space system without optical fiber.…”

Section: Introductionmentioning

confidence: 99%

Infrared laser transillumination CT imaging system using parallel fiber arrays and optical switches for finger joint imaging

et al. 2004

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The heterodyne detection technique, on which the coherent detection imaging (CDI) method founds, can discriminate and select very weak, highly directional forward scattered, and coherence retaining photons that emerge from scattering media in spite of their complex and highly scattering nature. That property enables us to reconstruct tomographic images using the same reconstruction technique as that of X-Ray CT, i.e., the filtered backprojection method. Our group had so far developed a transillumination laser CT imaging method based on the CDI method in the visible and near-infrared regions and reconstruction from projections, and reported a variety of tomographic images both in vitro and in vivo of biological objects to demonstrate the effectiveness to biomedical use. Since the previous system was not optimized, it took several hours to obtain a single image. For a practical use, we developed a prototype CDI-based imaging system using parallel fiber array and optical switches to reduce the measurement time significantly. Here, we describe a prototype transillumination laser CT imaging system using fiber-optic based on optical heterodyne detection for early diagnosis of rheumatoid arthritis (RA), by demonstrating the tomographic imaging of acrylic phantom as well as the fundamental imaging properties. We expect that further refinements of the fiber-optic-based laser CT imaging system could lead to a novel and practical diagnostic tool for rheumatoid arthritis and other joint-and bone-related diseases in human finger.

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Fundamental imaging properties of transillumination laser CT using optical fiber applicable to bio-medical sensing

Cited by 13 publications

References 27 publications

Finger joint imaging by laser transillumination computed tomography based on coherent detection imaging method

Finger joint imaging by laser transillumination computed tomography based on coherent detection imaging method

Pass-through photon-based biomedical transillumination

Infrared laser transillumination CT imaging system using parallel fiber arrays and optical switches for finger joint imaging

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