The Hadamard fractional derivative and integral are important parts of fractional calculus which have been widely used in engineering, biology, neural networks, control theory, and so on. In addition, the periodic boundary conditions are an important class of symmetric two-point boundary conditions for differential equations and have wide applications. Therefore, this article considers a class of nonlinear Hadamard fractional coupling (p1,p2)-Laplacian systems with periodic boundary value conditions. Based on nonlinear analysis methods and the contraction mapping principle, we obtain some new and easily verifiable sufficient criteria for the existence and uniqueness of solutions to this system. Moreover, we further discuss the generalized Ulam–Hyers (GUH) stability of this problem by using some inequality techniques. Finally, three examples and simulations explain the correctness and availability of our main results.