Fundamental research leading to improved endocrine therapy for breast cancer

Inhibitory effect of the novel anti-estrogen EM-800 and medroxyprogesterone acetate on estrone-stimulated growth of dimethylbenz[a]anthracene-induced mammary carcinoma in rats

“…Thus, special attention has focused on the mechanisms of action of estrogens and on the development of blockers of estrogen biosynthesis and action at the target cell level since the existing ablative procedures, either surgical or medical, do not permit complete elimination of estrogens (Miller, 1987;Wells and Santen, 1984).…”