Abstract-The support of mission-critical communication (MCC) opens the possibility to implement a broad range of novel applications. V2X communication for traffic safety and automation is, among others, one of these innovative applications expected to bring big benefits to society: accidents are prevented, driving times are reduced, and carbon dioxide is saved. In this regard, we first present a system model and fundamental definitions of reliability, latency and availability. Relying on these definitions, a systematic review of requirements for the huge variety of V2X applications is provided, including insights into the expected evolution towards autonomous driving. The many challenges introduced by V2X use cases are emphasized and compared to today's wireless system capabilities. Finally, we give our vision on the design of future radio technologies for the support of this kind of communications.