Fundamentals and Applications of Cyclodextrins

Crini, Grégorio; Fourmentin, Sophie; Fenyvesi, Éva; Torri, Giangiacomo; Fourmentin, Marc; Morin‐Crini, Nadia

doi:10.1007/978-3-319-76159-6_1

Cited by 45 publications

(41 citation statements)

References 275 publications

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“…However, to improve the dissolution profile of poorly soluble drugs, various approaches are proposed such as particle size reduction 4 , drug dispersion in carrier 5 , modification of crystal habit 6 , use of surfactant 7 , self-emulsifying formulations 8 , and complexation with cyclodextrins (CDs) 9 . This later is one of the frontier techniques that are employed in almost 56 pharmaceutical products 10 , where these oligomers obtained from enzymatic degradation of starch are exploited. These cycloamyloses are composed of D-glucopyranoside units linked by a(1 !…”

Section: Introductionmentioning

confidence: 99%

Solubility enhancement of mefenamic acid by inclusion complex with β-cyclodextrin: in silico modelling, formulation, characterisation, and in vitro studies

Sid

Baitiche

Elbahri

et al. 2021

Journal of Enzyme Inhibition and Medicinal Chemistry

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The aim of this study was to prepare and characterise inclusion complexes of a low water-soluble drug, mefenamic acid (MA), with b-cyclodextrin (b-CD). First, the phase solubility diagram of MA in b-CD was drawn from 0 to 21 Â 10 À3 M of b-CD concentration. A job's plot experiment was used to determine the stoichiometry of the MA:b-CD complex (2:1). The stability of this complex was confirmed by molecular modelling simulation. Three methods, namely solvent co-evaporation (CE), kneading (KN), and physical mixture (PM), were used to prepare the (2:1) MA:b-CD complexes. All complexes were fully characterised. The drug dissolution tests were established in simulated liquid gastric and the MA water solubility at pH 1.2 from complexes was significantly improved. The mechanism of MA released from the b-CD complexes was illustrated through a mathematical treatment. Finally, two in vitro experiments confirmed the interest to use a (2:1) MA:b-CD complex.

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Section: Introductionmentioning

confidence: 99%

Solubility enhancement of mefenamic acid by inclusion complex with β-cyclodextrin: in silico modelling, formulation, characterisation, and in vitro studies

Sid

Baitiche

Elbahri

et al. 2021

Journal of Enzyme Inhibition and Medicinal Chemistry

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“…At preliminary tests several sample preparation methods have been tried and we found that the highest drug content can be achieved by the method mentioned in Section 2.2.2 . The drug-cyclodextrin complexes were investigated in the solution state by NMR and in the solid state (as dry film) by FTIR measurements as the cyclodextrins affect on the absorbance spectra [ 42 , 43 ].…”

Section: Resultsmentioning

confidence: 99%

Highly Enhanced Curcumin Delivery Applying Association Type Nanostructures of Block Copolymers, Cyclodextrins and Polycyclodextrins

et al. 2020

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The limited bioavailability of the highly hydrophobic natural compound, curcumin with wide range of beneficial bioactivity is still a challenge. Self-association type systems of polyethylene oxide-polypropylene oxide-polyethylene oxide block copolymers (Pluronic) were applied to enhance the aqueous solubility of curcumin. Comparison of four Pluronics (94, 105, 127,108) with different compositions led to the conclusion that solubilization capacity is maximum for Pluronic 105 with intermediate polarity (hydrophilic/lipophilic balance (HLB) = 15) possessing the optimum balance between capacity of hydrophobic core of the micelle and hydrophilic stabilizing shell of the associate. Curcumin concentration in aqueous solution was managed to increase 105 times up to 1–3 g/L applying Pluronic at 0.01 mol/L. Formation of a host–guest complex of cyclodextrin as another way of increasing the curcumin solubility was also tested. Comparing the(2-hydroxypropyl)-α, β and γ cyclodextrins (CD) with 6, 7 and 8 sugar units and their polymers (poly-α-CD, poly-β-CD, poly-γ-CD) the γ-CD with the largest cavity found to be the most effective in curcumin encapsulation approaching the g/L range of concentration. The polymer type of the CDs presented prolonged and pH dependent release of curcumin in the gastrointestinal (GI) system modelled by simulated liquids. This retarding effect of polyCD was also shown and can be used for tuning in the combined system of Pluronic micelle and polyCD where the curcumin release was slower than from the micelle.

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“…Ważnym zadaniem substancji pomocniczych jest zapewnienie stabilności substancji leczniczej. W tym zastosowaniu w grupie węglowodanów dominuje wykorzystanie cyklodekstryn, cyklicznych pochodnych glukozy, bogato opisywanych w literaturze [12,13,14,15]. W kontekście podobieństwa ich budowy do cząsteczek liniowych, jakimi są maltodekstryny, zaczęto badać możliwość podobnego zastosowania w farmacji również tych mniej skomplikowanych cząsteczek.…”

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