Fundamentals and applications of zwitterionic antifouling polymers

Zhang, Yanxian; Liu, Yonglan; Ren, Baiping; Dong, Zhili; Xie, Songhai; Chang, Yung; Yang, Jintao; Wu, Jiang; Xu, Ling; Zheng, Jie

doi:10.1088/1361-6463/ab2cbc

Cited by 143 publications

(127 citation statements)

References 123 publications

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“…The use of a carboxylate as the anion at acidic environments resulted in the protonation and neutralization of the monomer units [ 51 ]. Zwitterionic polymers have great potential as anti-fouling coating, between other functionalities, because they can resist nonspecific protein adsorption, bacterial adhesion, and biofilm formation [ 53 ].…”

Section: Resultsmentioning

confidence: 99%

Incorporation of Poly(Itaconic Acid) with Quaternized Thiazole Groups on Gelatin-Based Films for Antimicrobial-Active Food Packaging

2021

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Poly(itaconic acid) (PIA) was synthesized via conventional radical polymerization. Then, functionalization of PIA was carried out by an esterification reaction with the heterocyclic groups of 1,3-thiazole and posterior quaternization by N-alkylation reaction with iodomethane. The modifications were confirmed by Fourier transform infrared (FTIR) and proton nuclear magnetic resonance (1H-NMR), as well as ζ-potential measurements. Their antimicrobial activity was tested against different Gram-negative and Gram-positive bacteria. After characterization, the resulting polymers were incorporated into gelatin with oxidized starch and glycerol as film adjuvants, and dopamine as crosslinking agent, to develop antimicrobial-active films. The addition of quaternized polymers not only improved the mechanical properties of gelatin formulations, but also decreased the solution absorption capacity during the swelling process. However, the incorporation of synthesized polymers increased the deformation at break values and the water vapor permeability of films. The antioxidant capacity of films was confirmed by radical scavenging ability and, additionally, those films exhibited antimicrobial activity. Therefore, these films can be considered as good candidates for active packaging, ensuring a constant concentration of the active compound on the surface of the food, increasing products’ shelf-life and reducing the environmental impact generated by plastics of petrochemical origin.

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Section: Resultsmentioning

confidence: 99%

Incorporation of Poly(Itaconic Acid) with Quaternized Thiazole Groups on Gelatin-Based Films for Antimicrobial-Active Food Packaging

2021

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“…[ 244–247 ] Based on their antifouling properties, zwitterionic polymers are widely used in surface modifications for antifouling, antibacterial, and anticoagulant, and other biomedical fields including biomedical diagnostics, immunomodulation, drug or gene delivery, separation membranes, and marine fouling. [ 248–255 ] Various types of zwitterions have been developed in recent decades. Sulfobetaine (SB), [ 256 ] carboxybetaine (CB), [ 257 ] and phosphorylcholine [ 258–262 ] based materials are the most widely used due to their ultra‐low fouling properties, which are result of the strong hydration through ionic solvation.…”

Section: New Materials To Resist the Fbrmentioning

confidence: 99%

Dealing with the Foreign‐Body Response to Implanted Biomaterials: Strategies and Applications of New Materials

Zhang

Chen

Shi

et al. 2020

Adv Funct Materials

176

139

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Foreign‐body response caused by implanted biomaterials seriously impedes the function of implants and is a major obstacle to the development of implantable biomaterials and medical devices. Recent advances in implantable biomaterials and medical devices have provided strategies to resist the foreign‐body response. In this review, the mechanism of the foreign‐body response and conventional strategies to mitigate foreign‐body response is briefly introduced. Then, three types of promising foreign‐body response resisting materials are focused and the advantages, characteristics, and applications of each material are discussed. Finally, prospects are put forward for future development of foreign‐body response resisting materials and current challenges that require in‐depth study.

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“…The positively charged moiety is usually a quaternary ammonium group and the negatively charged moiety can be a carboxylate, sulfonate, or phosphoryl group (Figure 11). Zwitterion ending coatings (ligands or polymers) have been extensively used in anti-biofouling materials [58,59]. The explanation for their great performance as protein repellents is based on their high hydration capability due to coulombic forces between water molecules and the charged moieties in zwitterions.…”

Section: Zwitterionsmentioning

confidence: 99%

Recent Developments in the Design of Non-Biofouling Coatings for Nanoparticles and Surfaces

Sanchez‐Cano

Carril

2020

IJMS

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Biofouling is a major issue in the field of nanomedicine and consists of the spontaneous and unwanted adsorption of biomolecules on engineered surfaces. In a biological context and referring to nanoparticles (NPs) acting as nanomedicines, the adsorption of biomolecules found in blood (mostly proteins) is known as protein corona. On the one hand, the protein corona, as it covers the NPs’ surface, can be considered the biological identity of engineered NPs, because the corona is what cells will “see” instead of the underlying NPs. As such, the protein corona will influence the fate, integrity, and performance of NPs in vivo. On the other hand, the physicochemical properties of the engineered NPs, such as their size, shape, charge, or hydrophobicity, will influence the identity of the proteins attracted to their surface. In this context, the design of coatings for NPs and surfaces that avoid biofouling is an active field of research. The gold standard in the field is the use of polyethylene glycol (PEG) molecules, although zwitterions have also proved to be efficient in preventing protein adhesion and fluorinated molecules are emerging as coatings with interesting properties. Hence, in this review, we will focus on recent examples of anti-biofouling coatings in three main areas, that is, PEGylated, zwitterionic, and fluorinated coatings.

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Fundamentals and applications of zwitterionic antifouling polymers

Cited by 143 publications

References 123 publications

Incorporation of Poly(Itaconic Acid) with Quaternized Thiazole Groups on Gelatin-Based Films for Antimicrobial-Active Food Packaging

Incorporation of Poly(Itaconic Acid) with Quaternized Thiazole Groups on Gelatin-Based Films for Antimicrobial-Active Food Packaging

Dealing with the Foreign‐Body Response to Implanted Biomaterials: Strategies and Applications of New Materials

Recent Developments in the Design of Non-Biofouling Coatings for Nanoparticles and Surfaces

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