Fundamentals of Fish Vaccination

Bedekar, Megha Kadam; Kole, Sajal

doi:10.1007/978-1-0716-1888-2_9

Cited by 8 publications

(14 citation statements)

References 138 publications

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“…On the other hand, IgT and IgD secretions in MALT are mainly associated with mucosal vaccination. 18 Since most infections exploit the mucosal surfaces as the port of entry and initial replication, 19 eliciting sufficient responses at these sites is vital. Nevertheless, thus far, all reports of specific antibody responses have focused on IgM, while no studies have reported the presence of vaccine-induced antigen-specific IgT or IgD antibodies in fish.…”

Section: Basic Principles Of Fish Vaccinologymentioning

confidence: 99%

“…Nevertheless, thus far, all reports of specific antibody responses have focused on IgM, while no studies have reported the presence of vaccine-induced antigen-specific IgT or IgD antibodies in fish. 17 Besides the antibody responses, 18 vaccines also induce cellmediated immunity, represented by the population of cytotoxic Tlymphocytes (CTLs). This subset, expressing the CD8 molecule and TCR-co-receptors, is vital for recognizing foreign antigens on MHC class I receptors, mediating the elimination of virus-infected cells.…”

Section: Basic Principles Of Fish Vaccinologymentioning

confidence: 99%

“…Generally, upon vaccination, the maximal production of IgM is achieved by intraperitoneal injection, although IgM is also reported to be secreted in serum and mucus upon immersion and oral vaccination. On the other hand, IgT and IgD secretions in MALT are mainly associated with mucosal vaccination 18 . Since most infections exploit the mucosal surfaces as the port of entry and initial replication, 19 eliciting sufficient responses at these sites is vital.…”

Section: Basic Principles Of Fish Vaccinologymentioning

confidence: 99%

“…Besides the antibody responses, 18 vaccines also induce cell‐mediated immunity, represented by the population of cytotoxic T‐lymphocytes (CTLs). This subset, expressing the CD8 molecule and TCR‐co‐receptors, is vital for recognizing foreign antigens on MHC class I receptors, mediating the elimination of virus‐infected cells.…”

Section: Basic Principles Of Fish Vaccinologymentioning

confidence: 99%

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Molecular farming: Expanding the field of edible vaccines for sustainable fish aquaculture

Mičúchová

Piačková

Frébort

et al. 2022

Reviews in Aquaculture

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Vaccines represent one of the most promising strategies for mitigating economic losses imposed by infectious diseases to global aquaculture. While the majority of commercial vaccines employ injection as the main route of delivery, a substantial body of research explores other avenues for the stimulation of protective immunity. Oral vaccines, representing the most favourable and convenient solution for the aquaculture industry, have been at the forefront of scientific interest for the last couple of decades. The orchestrated effort resulted in identifying the main roadblocks on the path to an ideal edible vaccine and provided several ingenious solutions improving the activation of immunity, ensuring the stability of administered antigens and their uptake upon the passage through the stomach. In the presented review, we describe advances in the available knowledge of the processes prerequisite for developing protective mucosal vaccines and focus readers' attention on the untapped potential of plant‐based production systems in this effort. We propose that these approaches not only meet production demands but also fulfil all requirements of an oral vaccine, addressing all the obstacles, previously solved via separate strategies, in one platform. Thus, combined with the available knowledge of molecular adjuvants and produced for a fraction of the cost, plant‐based production, so‐called molecular farming, is an ideal candidate for vaccine development, paving the road to sustainable aquaculture.

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Section: Basic Principles Of Fish Vaccinologymentioning

confidence: 99%

Section: Basic Principles Of Fish Vaccinologymentioning

confidence: 99%

Section: Basic Principles Of Fish Vaccinologymentioning

confidence: 99%

Section: Basic Principles Of Fish Vaccinologymentioning

confidence: 99%

See 2 more Smart Citations

Molecular farming: Expanding the field of edible vaccines for sustainable fish aquaculture

Mičúchová

Piačková

Frébort

et al. 2022

Reviews in Aquaculture

View full text Add to dashboard Cite

show abstract

“…Although there are various routes for administering the formulated vaccines into fish including immersion, oral and injection methods, however, most of the developed vaccines are administered through the injection method. Despite this route generally providing significant potency, it also generates some drawbacks and limitations, for example, stimulating fish stress, creating difficulty in handling small fish and requiring labor for large-scale farmed fish [ 4 ]. To overcome these restricted conditions, immersion and oral administrations have been considered for delivering streptococcal vaccines.…”

Section: Introductionmentioning

confidence: 99%

A Novel Efficient Piscine Oral Nano-Vaccine Delivery System: Modified Halloysite Nanotubes (HNTs) Preventing Streptococcosis Disease in Tilapia (Oreochromis sp.)

et al. 2022

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Generally, the injection method is recommended as the best efficient method for vaccine applications in fish. However, labor-intensive and difficult injection for certain fish sizes is always considered as a limitation to aquatic animals. To demonstrate the effectiveness of a novel oral delivery system for the piscine vaccine with nano-delivery made from nano clay, halloysite nanotubes (HNTs) and their modified forms were loaded with killed vaccines, and we determined the ability of the system in releasing vaccines in a mimic digestive system. The efficaciousness of the oral piscine vaccine nano-delivery system was evaluated for its level of antibody production and for the level of disease prevention in tilapia. Herein, unmodified HNTs (H) and modified HNTs [HNT-Chitosan (HC), HNT-APTES (HA) and HNT-APTES-Chitosan (HAC)] successfully harbored streptococcal bivalent vaccine with inactivated S. agalactiae, designated as HF, HAF, HCF and HACF. The releasing of the loading antigens in the mimic digestive tract demonstrated a diverse pattern of protein releasing depending on the types of HNTs. Remarkably, HCF could properly release loading antigens with relevance to the increasing pH buffer. The oral vaccines revealed the greatest elevation of specific antibodies to S. agalactiae serotype Ia in HCF orally administered fish and to some extent in serotype III. The efficacy of streptococcal disease protection was determined by continually feeding with HF-, HAF-, HCF- and HACF-coated feed pellets for 7 days in the 1st and 3rd week. HCF showed significant RPS (75.00 ± 10.83%) among the other tested groups. Interestingly, the HCF-treated group exhibited noticeable efficacy similar to the bivalent-vaccine-injected group (RPS 81.25 ± 0.00%). This novel nano-delivery system for the fish vaccine was successfully developed and exhibited appropriated immune stimulation and promised disease prevention through oral administration. This delivery system can greatly support animals’ immune stimulation, which conquers the limitation in vaccine applications in aquaculture systems. Moreover, this delivery system can be applied to carrying diverse types of biologics, including DNA, RNA and subunit protein vaccines.

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The current status and development forecasts of vaccines for aquaculture and its effects on bacterial and viral diseases

Mkulo,

Wang,

Amoah

et al. 2024

Microbial Pathogenesis

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Fundamentals of Fish Vaccination

Cited by 8 publications

References 138 publications

Molecular farming: Expanding the field of edible vaccines for sustainable fish aquaculture

Molecular farming: Expanding the field of edible vaccines for sustainable fish aquaculture

A Novel Efficient Piscine Oral Nano-Vaccine Delivery System: Modified Halloysite Nanotubes (HNTs) Preventing Streptococcosis Disease in Tilapia (Oreochromis sp.)

The current status and development forecasts of vaccines for aquaculture and its effects on bacterial and viral diseases

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