Fundamentals of magnet-actuated droplet manipulation on an open hydrophobic surface

Long, Zhicheng; Shetty, Abhishek; Solomon, Michael J.; Larson, Ronald G.

doi:10.1039/b819818g

Cited by 188 publications

(185 citation statements)

References 30 publications

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“…Water coexists with the close-packed MBs separated from the water plug, since water fills the gap in the cluster of the spherical MBs (Shikida et al 2006a, b;Long et al 2009). The carry-on water influences lIPELISA in two aspects: it avoids direct exposure of MBs to oil, and thus, provides a preservative environment for proteins (antigen, antibody, and enzyme) immobilized on the surface of the MBs; however, it transfers free AP-anti-Dig which, besides the immobilized AP-anti-Dig, induces an undesired enzymatic reaction in the following detection step.…”

Section: Carry-on Water Coexists With Close-packed Mbs In Oilmentioning

confidence: 98%

“…These forces, however, exhibit distinct dependencies on the length scale, L, of a cluster of MBs. Specifically, the total magnetic force applied on the close-packed MBs is approximately proportional to L 3 (Jackson, 1998;Shikida et al 2006a;Pamme 2006;Long et al 2009), whereas the capillary force is approximately proportional to L (Shikida et al 2006a;Long et al 2009). Thus, the magnetic force drops more rapidly than the capillary force when L decreases.…”

Section: Length Scale and Other Factors Affect The Manipulation Of Mbsmentioning

confidence: 99%

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Microfluidic inverse phase ELISA via manipulation of magnetic beads

Chen

Abolmatty

Faghri

2010

Microfluid Nanofluid

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We report a new technique for conducting immuno-diagnostics on a microfluidic platform. Rather than handling fluid reagents against a stationary solid phase, the platform manipulates analyte-coated magnetic beads through stationary plugs of fluid reagents to detect an antigenic analyte. These isolated but accessible plugs are preencapsulated in a microchannel by capillary force. We call this platform microfluidic inverse phase enzyme-linked immunosorbent assay (lIPELISA). lIPELISA has distinctive advantages in the family of microfluidic immunoassay. In particular, it avoids pumping and valving fluid reagents during assaying, thus leading to a lab-on-a-chip format that is free of instrumentation for fluid actuation and control. We use lIPELISA to detect digoxigenin-labeled DNA segments amplified from E. coli O157:H7 by polymerase chain reaction (PCR), and compare its detection capability with that of microplate ELISA. For 0.259 ng ll -1 of digoxigenin-labeled amplicon, lIPELISA is as responsive as the microplate ELISA. Also, we simultaneously conduct lIP-ELISA in two parallel microchannels.

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Section: Carry-on Water Coexists With Close-packed Mbs In Oilmentioning

confidence: 98%

Section: Length Scale and Other Factors Affect The Manipulation Of Mbsmentioning

confidence: 99%

Microfluidic inverse phase ELISA via manipulation of magnetic beads

Chen

Abolmatty

Faghri

2010

Microfluid Nanofluid

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“…However, although drops composed of strongly responsive fluids, such as paramagnetic liquids16, 17 or ferrofluids,18, 19, 20 are commonly actuated by magnets, the majority of conventional drops are made of diamagnetic liquids (for example, water and oil) and cannot be efficiently manipulated unless a strong magnetic field is applied. To our knowledge, the only strategy for moving discrete diamagnetic liquid entities in air using moderate magnetic fields has consisted in using magnetosensitive particles, dispersed inside the liquid21 or coating the liquid to form liquid marbles 14, 22, 23, 24, 25. Using magnetic particles inside or outside the liquid increases sample cost, reduces applicability, and poses the problem of sample contamination.…”

mentioning

confidence: 99%

Magnetic Actuation of Drops and Liquid Marbles Using a Deformable Paramagnetic Liquid Substrate

et al. 2017

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The magnetic actuation of deposited drops has mainly relied on volume forces exerted on the liquid to be transported, which is poorly efficient with conventional diamagnetic liquids such as water and oil, unless magnetosensitive particles are added. Herein, we describe a new and additive‐free way to magnetically control the motion of discrete liquid entities. Our strategy consists of using a paramagnetic liquid as a deformable substrate to direct, using a magnet, the motion of various floating liquid entities, ranging from naked drops to liquid marbles. A broad variety of liquids, including diamagnetic (water, oil) and nonmagnetic ones, can be efficiently transported using the moderate magnetic field (ca. 50 mT) produced by a small permanent magnet. Complex trajectories can be achieved in a reliable manner and multiplexing potential is demonstrated through on‐demand drop fusion. Our paramagnetofluidic method advantageously works without any complex equipment or electric power, in phase with the necessary development of robust and low‐cost analytical and diagnostic fluidic devices.

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“…Nowadays, ferrofluids are used in many fields including micro-pumps and micro-fluidic devices (Hartshorne et al, 2004 andLink et al 2006), electro-magnetic control of droplet (Long et al, 2009;Nguyen et al, 2009 andAfkhami et al 2008), optics (Sheikholeslami et al, 2015;Khan et al, 2015;Laird et al, 2004), nanotechnologies (Yellen et al, 2004 andZahn, 2001), heat transfer (Lajevardi et al, 2010, Malekzadeh et al, 2015and Prakash, 2013, and many other industrial fields (Rosenweig, 2013).…”

Section: Introductionmentioning

confidence: 99%

Ferrofluid Appendages: Fluid Fins, a Numerical Investigation on the Feasibility of using Fluids as Shapeable Propulsive Appendages

Chekab

Ghadimi

2017

JAFM

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The present study focuses on the feasibility of using fluids, and in particular magnetic fluids, as "Fluid Structures" in designing external appendages for the submerged bodies and propulsive fins as a practical example. After reviewing the literature of the mathematical simulation of magnetic fluids and their applications, the concept of "Fluid Structures" and "Fluid Fins" are briefly introduced. The validation of the numerical solver against analytical solutions is presented and acceptable error of 1.21% up to 2.29% is estimated. Subsequently, the initial shaping of the ferrofluid as an external fluid fin, using three combinations of internal magnetic actuators, is presented which makes the way to the oscillating motion of the obtained fin, by producing a periodically changing magnetic field. It is demonstrated that the shape of the fluid fin is almost the replica of the magnetic field. On the other hand, it is illustrated that a fluid fin with a size under 0.005 m on a circular submerged body of 1cm diameter could produce 0.0158 N force which is a high thrust force relative to the size of the body and the fin. Based on the obtained results, one may conclude that, when a "Fluid Fin" is capable of producing this amount of thrust, other fluid appendages could be scientifically contemplated and practically designed.

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Fundamentals of magnet-actuated droplet manipulation on an open hydrophobic surface

Cited by 188 publications

References 30 publications

Microfluidic inverse phase ELISA via manipulation of magnetic beads

Microfluidic inverse phase ELISA via manipulation of magnetic beads

Magnetic Actuation of Drops and Liquid Marbles Using a Deformable Paramagnetic Liquid Substrate

Ferrofluid Appendages: Fluid Fins, a Numerical Investigation on the Feasibility of using Fluids as Shapeable Propulsive Appendages

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