Fundamentals of redox regulation in biology

Sies, Helmut; Mailloux, Ryan J.; Jakob, Ursula

doi:10.1038/s41580-024-00730-2

Cited by 39 publications

(1 citation statement)

References 287 publications

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“…5 C–F). These data indicate that NOX2 is required to maintain the cellular redox balance needed for proper eNOS function [ 42 ]. Thus, eNOS activation and NO ● formation are highly dependent on H 2 O 2 signaling, which is blocked following EROS knockdown in endothelial cells.…”

Section: Discussionmentioning

confidence: 99%

An essential role for EROS in redox-dependent endothelial signal transduction

Waldeck-Weiermair,

Das,

Covington

et al. 2024

Redox Biology

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Section: Discussionmentioning

confidence: 99%

An essential role for EROS in redox-dependent endothelial signal transduction

Waldeck-Weiermair,

Das,

Covington

et al. 2024

Redox Biology

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Customized Corneal Cross‐Linking with Microneedle‐Mediated Riboflavin Delivery for Keratoconus Treatment

Yang,

Pan,

Chen

et al. 2024

Advanced Materials

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In this study, a novel customized corneal cross‐linking (CXL) treatment is explored that utilizes microneedles (MNs) for targeted riboflavin (RF) administration prior to the CXL procedure. Unlike the conventional “one‐size‐fits‐all” approach, this protocol offers an option for more precise and efficacious treatment. To simulate a customized corneal crosslinking technique, four distinct microneedle (MN) molds designs, including circular, semi‐circular, annular and butterfly shaped, are crafted for loading an optimized RF‐hyaluronic acid solution and for the subsequent fabrication of MN arrays with varying morphologies. These MNs can gently puncture the corneal epithelium while preserving the integrity of the underlying stromal layer. Following the application of these microneedles, RF solution is replenished to enhance the RF content within the stroma through the punctures created by the MNs, resulting in exceptional customized corneal cross‐linking effects that are comparable to the conventional epi‐off CXL protocol. Additionally, it flattened the corneal curvature within the treated zone and facilitated rapid postoperative recovery of corneal tissue. These findings suggest that the integration of customized microneedle RF delivery with corneal crosslinking technology represents a potential novel treatment modality, holding promise for the tailored treatment of corneal pathologies, and offering a more precise and efficient alternative to traditional methods.

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Catalytic Biomaterials‐Activated In Situ Chemical Reactions: Strategic Modulation and Enhanced Disease Treatment

Wang,

He,

Liao

et al. 2024

Advanced Materials

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Chemical reactions underpin biological processes, and imbalances in critical biochemical pathways within organisms can lead to the onset of severe diseases. Within this context, the emerging field of “Nanocatalytic Medicine” leverages nanomaterials as catalysts to modulate fundamental chemical reactions specific to the microenvironments of diseases. This approach is designed to facilitate the targeted synthesis and localized accumulation of therapeutic agents, thus enhancing treatment efficacy and precision while simultaneously reducing systemic side effects. The effectiveness of these nanocatalytic strategies critically hinges on a profound understanding of chemical kinetics and the intricate interplay of reactions within particular pathological microenvironments to ensure targeted and effective catalytic actions. This review methodically explores in situ catalytic reactions and their associated biomaterials, emphasizing regulatory strategies that control therapeutic responses. Furthermore, the discussion encapsulates the crucial elements‐reactants, catalysts, and reaction conditions/environments‐necessary for optimizing the thermodynamics and kinetics of these reactions, while rigorously addressing both the biochemical and biophysical dimensions of the disease microenvironments to enhance therapeutic outcomes. It seeks to clarify the mechanisms underpinning catalytic biomaterials and evaluate their potential to revolutionize treatment strategies across various pathological conditions.

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Fundamentals of redox regulation in biology

Cited by 39 publications

References 287 publications

An essential role for EROS in redox-dependent endothelial signal transduction

An essential role for EROS in redox-dependent endothelial signal transduction

Customized Corneal Cross‐Linking with Microneedle‐Mediated Riboflavin Delivery for Keratoconus Treatment

Catalytic Biomaterials‐Activated In Situ Chemical Reactions: Strategic Modulation and Enhanced Disease Treatment

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