Fundamentals of utilizing microbes in advanced cancer therapeutics: current understanding and potential applications

Kaur, Tashmeen; Sharma, Deepika

doi:10.1016/bs.aambs.2023.03.001

Cited by 2 publications

(2 citation statements)

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“…Numerous clinical trials have been undertaken to assess the effectiveness and safety of utilizing therapeutic bacteria and viruses in the treatment of cancer. These studies have explored different facets of using microbial agents for anticancer therapies, such as their efficacy in attacking and eradicating cancerous cells, their influence on tumor reduction, and their possible negative consequences on individuals undergoing treatment [ 366 , 367 ]. A clinical trial in phase 1b investigated the impact of oncolytic virotherapy, Talimogene laherparepvec (T-VEC), in combination with pembrolizumab, an anti-PD-1 antibody, among individuals diagnosed with advanced melanoma.…”

Section: Introductionmentioning

confidence: 99%

“…Bacterial and viral therapies have demonstrated potential efficacy in cancer treatment; however, it is essential to acknowledge the existing limitations and potential disadvantages associated with these treatment modalities. One constraint involves safeguarding unaffected tissues while stimulating immune reactions [ 366 ]. Moreover, specific bacteria and viruses can potentially impede the mechanisms responsible for preserving genetic stability and cellular restoration, thereby diminishing the efficacy of therapeutic interventions [ 409 – 411 ].…”

Section: Introductionmentioning

confidence: 99%

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Therapeutic bacteria and viruses to combat cancer: double-edged sword in cancer therapy: new insights for future

Yarahmadi,

Zare,

Aghayari

et al. 2024

Cell Commun Signal

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Cancer, ranked as the second leading cause of mortality worldwide, leads to the death of approximately seven million people annually, establishing itself as one of the most significant health challenges globally. The discovery and identification of new anti-cancer drugs that kill or inactivate cancer cells without harming normal and healthy cells and reduce adverse effects on the immune system is a potential challenge in medicine and a fundamental goal in Many studies. Therapeutic bacteria and viruses have become a dual-faceted instrument in cancer therapy. They provide a promising avenue for cancer treatment, but at the same time, they also create significant obstacles and complications that contribute to cancer growth and development. This review article explores the role of bacteria and viruses in cancer treatment, examining their potential benefits and drawbacks. By amalgamating established knowledge and perspectives, this review offers an in-depth examination of the present research landscape within this domain and identifies avenues for future investigation. Graphical Abstract The double-edged sword role of bacteria and viruses in cancer therapy.

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Section: Introductionmentioning

confidence: 99%