Funding has no effect on studies evaluating viscosupplementation for knee osteoarthritis: A systematic review of bibliometrics and conflicts of interest

Via, Garrhett G.; Brueggeman, David A.; Lyons, Joseph G.; Frommeyer, Timothy C.; Froehle, Andrew W.; Krishnamurthy, Anil

doi:10.1016/j.jor.2023.03.015

Cited by 6 publications

(2 citation statements)

References 25 publications

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“…Circumstances such as these, that “create a risk that judgments or actions regarding a primary interest will be unduly influenced by a secondary interest are defined as conflicts of interest (COI)” [ 3 ]. COI stemming from industry funding can, although do not always [ 4 ], bias design, recruitment, conduct, choice of outcome measures, or reporting, all of which have the potential to distort study findings and undermine medical practice [ 5 – 7 ]. The United States Centers for Medicare & Medicaid Services Open Payments [ 8 ] database documents any industry payment of at least $10 and annual payments of $100 or more made to American physician researchers since 2013.…”

Section: Introductionmentioning

confidence: 99%

Extent, transparency and impact of industry funding for pelvic mesh research: a review of the literature

Coderre-Ball,

Phillips

2024

Res Integr Peer Rev

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Background Conflicts of interest inherent in industry funding can bias medical research methods, outcomes, reporting and clinical applications. This study explored the extent of funding provided to American physician researchers studying surgical mesh used to treat uterine prolapse or stress urinary incontinence, and whether that funding was declared by researchers or influenced the ethical integrity of resulting publications in peer reviewed journals. Methods Publications identified via a Pubmed search (2014–2021) of the terms mesh and pelvic organ prolapse or stress urinary incontinence and with at least one US physician author were reviewed. Using the CMS Open Payments database industry funding received by those MDs in the year before, of and after publication was recorded, as were each study’s declarations of funding and 14 quality measures. Results Fifty-three of the 56 studies reviewed had at least one American MD author who received industry funding in the year of, or one year before or after publication. For 47 articles this funding was not declared. Of 247 physician authors, 60% received > $100 while 13% received $100,000-$1,000,000 of which approximately 60% was undeclared. While 57% of the studies reviewed explicitly concluded that mesh was safe, only 39% of outcomes supported this. Neither the quality indicator of follow-up duration nor overall statements as to mesh safety varied with declaration status. Conclusions Journal editors’ guidelines re declaring conflicts of interest are not being followed. Financial involvement of industry in mesh research is extensive, often undeclared, and may shape the quality of, and conclusions drawn, resulting in overstated benefit and overuse of pelvic mesh in clinical practice.

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Section: Introductionmentioning

confidence: 99%

Extent, transparency and impact of industry funding for pelvic mesh research: a review of the literature

Coderre-Ball,

Phillips

2024

Res Integr Peer Rev

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“…[1][2][3] Especially after early sports traumata with persisting cartilage injuries, OA can also manifest itself much earlier. [4][5][6][7] If conservative treatment fails, partial or total knee arthroplasty is often performed. [8][9][10] A joint arthroplasty aims to generate again a stable joint with smoothly articulating surfaces to free the patient of joint pain, to correct prior deformities and thus restore the disrupted function of the degenerated joint.…”

Section: Introductionmentioning

confidence: 99%

Fostering Excellence in Knee Arthroplasty: Developing Optimal Patient Care Pathways and Inspiring Knowledge Transfer of Advanced Surgical Techniques

Migliorini,

Feierabend,

Hofmann

2023

JHL

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Osteoarthritis of the knee is common. Early sports trauma or cartilage defects are risk factors for osteoarthritis. If conservative treatment fails, partial or total joint replacement is often performed. A joint replacement aims to restore physiological biomechanics and the quality of life of affected patients. Total knee arthroplasty is one of the most performed surgeries in musculoskeletal medicine. Several developments have taken place over the last decades that have truly altered the way we look at knee arthroplasty today. Some of the fascinating aspects will be presented and discussed in the present narrative review.

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Functional alignment in robotic-assisted total knee arthroplasty: a systematic review

Migliorini,

Pilone,

Schäfer

et al. 2024

Arch Orthop Trauma Surg

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Funding has no effect on studies evaluating viscosupplementation for knee osteoarthritis: A systematic review of bibliometrics and conflicts of interest

Cited by 6 publications

References 25 publications

Extent, transparency and impact of industry funding for pelvic mesh research: a review of the literature

Extent, transparency and impact of industry funding for pelvic mesh research: a review of the literature

Fostering Excellence in Knee Arthroplasty: Developing Optimal Patient Care Pathways and Inspiring Knowledge Transfer of Advanced Surgical Techniques

Functional alignment in robotic-assisted total knee arthroplasty: a systematic review

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